GLP Watchdog

Best Weight Loss Shots in 2026: Ranked and Reviewed

When people say “weight loss shots” they nearly always mean GLP-1 injections. That is semaglutide, sold as Wegovy, as Ozempic and in compounded form, and tirzepatide, sold as Zepbound, as Mounjaro and compounded. Older injections marketed for the same purpose — HCG, lipotropic (MIC) and B12 — carry no comparable evidence. GLP-1s are the shots that work. What follows is the name of each one, what a month of it really costs, and a ranked list of the telehealth providers prescribing them online.

Lowest verified price: $47/mo630 providers compared

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By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

630 weight loss shots compared · independently scored against our six-factor methodology.

Quick Picks

Starting price per provider. Prices in USD per month; checked November 2026.
#ProviderScore
1EmbodyVisit
2SnagRxVisit
3CollectiveVisit
4CoreAge RxVisit
5LttlVisit

Compare the top providers at a glance

Every row carries a logo, our editorial rating, price, the medications prescribed, and where the seller ships. Scan down a column and the list shortens fast.

  • ★ Editor's Pick
    Embody

    a flat compounded tirzepatide or semaglutide price at every dose, from a seller that names its pharmacies

    From /mo
    $79
    Coverage
    50 states + DC
    Medications
    SemaglutideTirzepatide
    Visit →
  • SnagRx

    semaglutide at $99/month, well below the typical price

    From /mo
    $99
    Flat at every dose
    Coverage
    49 states
    Medications
    SemaglutideTirzepatide
    Visit →
  • Best Budget
    Collective

    flat any-dose pricing, if you can absorb a $199 annual membership on top

    From /mo
    $59+ membership
    Flat at every dose
    Coverage
    44 states
    Medications
    SemaglutideTirzepatide
    Visit →
Show 5 more
  • CoreAge Rx

    flat-priced compounded semaglutide at $79 a month, any dose

    From /mo
    $79
    Flat at every dose
    Coverage
    48 states
    Medications
    SemaglutideTirzepatide
    Visit →
  • Nationwide Coverage
    Lttl

    starting below a standard dose, with microdose tiers

    From /mo
    $99
    Flat at every dose
    Coverage
    50 states + DC
    Medications
    SemaglutideTirzepatide
    Visit →
  • YourEra

    semaglutide at $99/month, well below the typical price

    From /mo
    $99
    Flat at every dose
    Coverage
    50 states
    Medications
    SemaglutideTirzepatide
    Visit →
  • altRX

    compounded semaglutide from $89/month at the same price at every dose

    From /mo
    $89
    Flat at every dose
    Coverage
    50 states
    Medications
    SemaglutideTirzepatide
    Visit →
  • Eden

    coverage in all 50 states, which most sellers will not confirm

    From /mo
    $99
    Flat at every dose
    Coverage
    50 states
    Medications
    SemaglutideTirzepatide
    Visit →
All 630 providers on this board, in the order this board shows them

The comparison above shows the first 8. This is the full list the filter counts refer to, in the order this board shows them; each name opens that provider’s review.

6weighted dimensions
630weight loss shots compared
Everychecked against the seller's own site
Value 25%Effectiveness 25%User Experience 15%Trust & Safety 15%Accessibility 10%Support 10%

A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →

Every weight loss shot by name, and which ones the evidence backs

When people search “weight loss shots,” they almost always mean the GLP-1 injections: semaglutide (sold as Wegovy and Ozempic) and tirzepatide (Zepbound and Mounjaro), plus the lower-cost compounded versions. Older injectables marketed for weight loss — B12, lipotropic (MIC), and HCG shots — have no comparable evidence. Here is every shot by name, what is actually in it, and whether the data supports it.

GLP-1 shots — the ones with trial evidence

Brand name, what is inside it, and what the trials measured, for each GLP-1 injection
ShotActive ingredientClassTypical resultVerdict
WegovysemaglutideGLP-1~15% body weight (STEP-1, 68 wk)Evidence-backed
ZepboundtirzepatideGLP-1 / GIP~21% body weight (SURMOUNT-1, 72 wk)Evidence-backed
OzempicsemaglutideGLP-1Same molecule as Wegovy (diabetes label)Evidence-backed
MounjarotirzepatideGLP-1 / GIPSame molecule as Zepbound (diabetes label)Evidence-backed
SaxendaliraglutideGLP-1~8% body weight (SCALE, daily shot)Evidence-backed
Compounded semaglutide / tirzepatidesemaglutide / tirzepatideGLP-1Same active ingredient; lower cash costEvidence-backed

Older “weight loss shots” — no comparable evidence

What the record shows for B12, lipotropic and HCG injections sold for weight loss
ShotActive ingredientClassTypical resultVerdict
B12 (cyanocobalamin) shotsvitamin B12VitaminNo weight-loss effect unless B12-deficientNo evidence
Lipotropic / MIC shotsmethionine, inositol, cholineAmino/lipotropicNo controlled evidence of fat lossNo evidence
HCG shotshuman chorionic gonadotropinHormoneNo substantial evidence per FDA; weight-loss claims prohibitedNo evidence

A B12 injection does nothing for weight unless you were deficient to begin with, and then only at one remove. Nobody has run a controlled trial showing that a lipotropic or MIC shot takes fat off. On HCG, FDA’s position is that no substantial evidence supports it for weight loss, and marketing it that way is not allowed. A clinic selling any of the three as a weight-loss shot has told you something about itself. The longer version: do B12, lipotropic (MIC), and HCG shots work. The GLP-1s are themselves peptides, which is worth reading about separately — peptide shots for weight loss.

The sellers ranked above will prescribe the evidence-backed ones online. If it is the drug rather than the seller you want to understand, start with the semaglutide and tirzepatide guides. The ranked board sits at best weight loss injections.

Detailed Reviews

1

Embody

Verified partner

Best for: a flat compounded tirzepatide or semaglutide price at every dose, from a seller that names its pharmacies

9.3

Embody is the brand Modern Metabolic Medicine, Inc. runs through its JoinEm storefront. It sells compounded semaglutide and tirzepatide injections at one price per drug at every dose, $79 and $129 for a one-month supply, plus a compounded oral tirzepatide gum. You pay at checkout, before an OpenLoop Health clinician decides on a prescription, and payments are final.

Score Breakdown

Value25%
10
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
10
Support10%
7

Pros

  • ✓Semaglutide costs $79 a month, 60% below the $199 median for compounded semaglutide across the sellers we compare
  • ✓Tirzepatide costs $129 a month, 52% below the $269 median for compounded tirzepatide across the sellers we compare
  • ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • ✓The monthly price includes the medication, clinician visits and shipping
  • ✓Serves all 50 states and DC
  • ✓Names 4 pharmacies that fill its prescriptions, which most sellers do not
  • ✓We found no FDA warning letters issued to Embody

Cons

  • ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Starting from $79/moRead full review →
Visit Embody →
2

SnagRx

Verified partner

Best for: semaglutide at $99/month, well below the typical price

9.2

SnagRx sells compounded semaglutide at $99 a month and compounded tirzepatide at $149 a month on its 1-month plan, one price at every dose. Longer plans cut the monthly rate but are charged in full up front and are non-refundable. Clinicians come from the OpenLoop Health network; the platform is Modern Metabolic Medicine, Inc. The visit and 1-2 day shipping are included, with no insurance and no membership.

Score Breakdown

Value25%
10
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
9.8
Support10%
7

Pros

  • ✓Semaglutide costs $99 a month, 50% below the $199 median for compounded semaglutide across the sellers we compare
  • ✓Tirzepatide costs $149 a month, 45% below the $269 median for compounded tirzepatide across the sellers we compare
  • ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • ✓The monthly price stays the same as your dose goes up
  • ✓The monthly price includes the medication, clinician visits and shipping
  • ✓Serves 49 states
  • ✓Names 4 pharmacies that fill its prescriptions, which most sellers do not
  • ✓We found no FDA warning letters issued to SnagRx

Cons

  • ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Starting from $99/moRead full review →
Visit SnagRx →
3

Collective

Verified partner

Best for: flat any-dose pricing, if you can absorb a $199 annual membership on top

9.1
Score breakdown, pros and cons

Health For Everyone Inc., trading as CollectiveOS, sells compounded semaglutide at $59/mo and compounded tirzepatide at $69/mo on a membership model, with a mandatory $199 annual membership on top that the headline price does not include. It prices every dose the same, so the cost does not climb as the dose is titrated, and it does not require prepaying for medication. The site is marketed as being from the founder of Thrive Market. Neither its pharmacies nor its medical groups are named.

Score Breakdown

Value25%
10
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
9
Support10%
7

Pros

  • ✓Semaglutide costs $59 a month for the medication, plus a required membership, 70% below the $199 median for compounded semaglutide across the sellers we compare
  • ✓Tirzepatide costs $69 a month for the medication, plus a required membership, 74% below the $269 median for compounded tirzepatide across the sellers we compare
  • ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • ✓The monthly price stays the same as your dose goes up
  • ✓The monthly price includes the medication, clinician visits and shipping
  • ✓Serves 44 states
  • ✓Told us Wells Pharmacy Network is one of the pharmacies that fill its prescriptions, though its site names none
  • ✓We found no FDA warning letters issued to Collective

Cons

  • ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Starting from $59/mo + membershipRead full review →
Visit Collective →
4

CoreAge Rx

Verified partner

Best for: flat-priced compounded semaglutide at $79 a month, any dose

9.0
Score breakdown, pros and cons

CoreAge Rx charges the same amount at every dose of its compounded GLP-1s: semaglutide is $79 a month, tirzepatide $129. Consult and shipping are inside that figure, and there is no membership fee. You pay before a doctor reviews the case, and every prescription sale is final once it reaches the pharmacy.

Score Breakdown

Value25%
10
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
9.7
Support10%
7

Pros

  • ✓Semaglutide costs $79 a month, 60% below the $199 median for compounded semaglutide across the sellers we compare
  • ✓Tirzepatide costs $129 a month, 52% below the $269 median for compounded tirzepatide across the sellers we compare
  • ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • ✓The monthly price stays the same as your dose goes up
  • ✓The monthly price includes the medication, clinician visits and shipping
  • ✓Serves 48 states
  • ✓We found no FDA warning letters issued to CoreAge Rx

Cons

  • ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
  • ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Starting from $79/moRead full review →
Visit CoreAge Rx →
5

Lttl

Verified partner

Best for: starting below a standard dose, with microdose tiers

9.0
Score breakdown, pros and cons

Lttl sells compounded semaglutide at $99 a month and tirzepatide at $149 a month on its month-to-month plan, one flat price at any dose. Prepaying for 12 months lowers those to $89 and $139. Every price and commitment length is on a public plans page before checkout. A microdose line at $149 a month and longevity peptides fill out the catalog.

Score Breakdown

Value25%
10
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7

Pros

  • ✓Semaglutide costs $99 a month, 50% below the $199 median for compounded semaglutide across the sellers we compare
  • ✓Tirzepatide costs $149 a month, 45% below the $269 median for compounded tirzepatide across the sellers we compare
  • ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • ✓The monthly price stays the same as your dose goes up
  • ✓The monthly price includes the medication, clinician visits and shipping
  • ✓Serves all 50 states and DC
  • ✓We found no FDA warning letters issued to Lttl

Cons

  • ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
  • ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Starting from $99/moRead full review →
Visit Lttl →

Which weight loss shots work, and who sells them

Not every injection sold for weight loss has evidence behind it. The GLP-1s, semaglutide and tirzepatide, do. HCG, B12 and lipotropic (MIC) shots do not, whatever the clinic selling them says on its site. Apply that filter first, and what remains is a comparison of GLP-1 sellers.

What to check

  • A GLP-1 rather than a vitamin. Not one of B12, lipotropic blends, or HCG produces weight loss on its own. A clinic marketing them for that purpose has told you what kind of clinic it is. Semaglutide and tirzepatide are the injections with results behind them.
  • A named pharmacy carrying certification. Where the shot is compounded, one disclosure outweighs the rest: a 503A or 503B pharmacy identified by name, with LegitScript certification attached to it. Nothing else on a marketing page substitutes for that.
  • Pricing that survives month one. A cheap opening month that steps up at each dose increase is common in this market, as is a membership charge billed beside the drug. Month two, at full dose, with every recurring line added, is the honest figure.

Red flags

  • Pharmacy unnamed and no LegitScript listing. Two disclosures are checkable on any compounded-GLP-1 seller: the 503A or 503B pharmacy filling the vial, and a LegitScript certification. When a site publishes neither, nothing about the contents of that vial can be confirmed from outside.
  • Instant approval with no clinician you can reach. A prescriber is supposed to read the intake and stay available once dose questions start. Approval issued automatically, with nobody reachable afterward, means the medical layer was removed rather than streamlined.
  • The advertised number is a first month. Headline figures here are usually qualified somewhere. Common forms are an opening rate that steps up with each dose increase, and a membership fee billed separately from the drug itself. Either one can double what leaves your account in month two.
  • B12, MIC, or HCG sold for weight loss. Trial evidence for weight loss sits with the GLP-1 injections and nowhere else on this aisle. A clinic that lists lipotropic, B12, or HCG shots under weight loss is selling past the record, whatever its own site says.

Every seller listed above is scored on these criteria under our six-dimension methodology, with prices re-checked against the seller’s own live site.

How we rank, and what counts as “legit”

Scoring for every provider on this page runs against our published six-factor rubric[1]: value, effectiveness, user experience, trust & safety, accessibility and support.

Each of Wegovy, Zepbound, Ozempic and Mounjaro holds its own separate FDA approval under its own NDA number[4][5]. Published Phase 3 efficacy for semaglutide at 2.4 mg (~14.9% mean weight loss across 68 weeks) comes from STEP 1[6]; those for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) come from SURMOUNT-1[7]. In 2025 the SURMOUNT-5 head-to-head set the two against each other[8].

How much of an anti-obesity medication is covered varies widely between state Medicaid programs and between commercial plans[9][10]. Under IRS Publication 502, compounded GLP-1s and brand-name ones alike are generally FSA/HSA eligible where a prescription exists[11].

Price and states served both move. Read them off the seller's own site before you enroll.How our reviews work →

Frequently Asked Questions

Two shots carry real trial evidence, and both are GLP-1 injections: semaglutide (Wegovy, ~15%) and tirzepatide (Zepbound, ~21% body-weight loss). Older injections marketed for the same purpose — HCG, lipotropic (MIC), B12 — have nothing comparable behind them. Which of the two suits you comes down to cost, to side effects, and to what your prescriber recommends.
Compounded semaglutide and tirzepatide through a telehealth provider carry the lowest cash prices, often $79–$199/month, set against brand-name Wegovy or Ozempic bought direct from Novo Nordisk without insurance, which starts at $349 a month. For an eligible insured patient, a manufacturer savings card can bring the brand-name cost down. Compare the real monthly totals in the list above, membership fee included.
One GLP-1 safety profile covers both semaglutide (Ozempic) and tirzepatide (Mounjaro). Gastrointestinal side effects dominate it, nausea and constipation, and they ease as the dose is raised slowly. Rodent studies also produced the thyroid C-cell tumor finding that sits in a boxed warning on both. Neither drug is 'safer' as a class. The choice is individual, and it belongs with a prescriber who has reviewed your history.
Six weighted dimensions produce the score. Value (25%) and Effectiveness (25%) carry the most, then User Experience (15%) and Trust & Safety (15%), then Accessibility (10%) and Support (10%). Behind them sits our research into pricing data, clinical evidence, user reviews and publicly available information. Those weights then combine into one overall score out of 10.
The six-dimension methodology computes each score on its own, and no commercial relationship ever moves a provider's underlying number. Every provider's full score sits on its card for you to check. Some providers do hold affiliate agreements with us, which means a commission reaches us if you click through and buy. On the lists carrying the highest commercial intent — the weight-loss injection and shot lists, the semaglutide and tirzepatide lists, the compounded and cheapest molecule lists, and the fitness-app list — affiliate partners take the top positions. Every other list runs in score order, or in price order on the cheapest lists. That placement is disclosed here, on our methodology page, and on our affiliate-disclosure page.
Sources & methodology — as of November 2026
  1. 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  5. 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  8. 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.
  9. 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  10. 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
  11. 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.

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