Best Weight Loss Shots in 2026 — Ranked & Reviewed
When people say “weight loss shots” they nearly always mean GLP-1 injections. That is semaglutide, sold as Wegovy, as Ozempic and in compounded form, and tirzepatide, sold as Zepbound, as Mounjaro and compounded. Older injections marketed for the same purpose — HCG, lipotropic (MIC) and B12 — carry no comparable evidence. GLP-1s are the shots that work. What follows is the name of each one, what a month of it really costs, and a ranked list of the telehealth providers prescribing them online.
Lowest verified price: $59/mo492 providers compared
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492 weight loss shots compared · independently scored against our six-factor methodology.
Compare the top providers at a glance
Every row carries a logo, our editorial rating, price, the medications prescribed, and where the seller ships. Scan down a column and the list shortens fast.
- ★ Editor's Pick
knowing which pharmacy fills the vial: it names VialsRx
From /mo$99Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatide - Nationwide Coverage
knowing which pharmacy fills the vial: it names RedRock Pharmacy
From /mo$79Coverage50 statesMedicationsSemaglutideTirzepatide semaglutide at $99/month, 48% below the typical price
From /mo$99Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatide
Show 5 moreShow fewer
starting below a standard dose, with microdose tiers
From /mo$99Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatidesemaglutide at $99/month, 48% below the typical price
From /mo$99Coverage50 statesMedicationsSemaglutideTirzepatidemoving between compounded and brand without changing seller
From /mo$129Flat at every doseCoverage50 statesMedicationsSemaglutideTirzepatidetirzepatide at $169/month, 37% below the typical price
From /mo$99Coverage50 statesMedicationsSemaglutideTirzepatide- Best Budget
flat any-dose pricing, if you can absorb a $199 annual membership on top
From /mo$59Flat at every doseCoverageCheck intakeMedicationsSemaglutideTirzepatide
| Provider | Rating | From /mo | Medications | Coverage | |
|---|---|---|---|---|---|
★ Editor's Pick knowing which pharmacy fills the vial: it names VialsRx | $99 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
Nationwide Coverage knowing which pharmacy fills the vial: it names RedRock Pharmacy | $79 | SemaglutideTirzepatide | 50 states | Visit → | |
 semaglutide at $99/month, 48% below the typical price | $99 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
 starting below a standard dose, with microdose tiers | $99 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
 semaglutide at $99/month, 48% below the typical price | $99 | SemaglutideTirzepatide | 50 states | Visit → | |
 moving between compounded and brand without changing seller | $129 Flat pricing | SemaglutideTirzepatide | 50 states | Visit → | |
 tirzepatide at $169/month, 37% below the typical price | $99 | SemaglutideTirzepatide | 50 states | Visit → | |
| Best Budget CO Collectiveflat any-dose pricing, if you can absorb a $199 annual membership on top | $59 Flat pricing | SemaglutideTirzepatide | Check intake | Visit → |
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
Every weight loss shot by name, and which ones the evidence backs
When people search “weight loss shots,” they almost always mean the GLP-1 injections: semaglutide (sold as Wegovy and Ozempic) and tirzepatide (Zepbound and Mounjaro), plus the lower-cost compounded versions. Older injectables marketed for weight loss — B12, lipotropic (MIC), and HCG shots — have no comparable evidence. Here is every shot by name, what is actually in it, and whether the data supports it.
GLP-1 shots — the ones with trial evidence
| Shot | Active ingredient | Class | Typical result | Verdict |
|---|---|---|---|---|
| Wegovy | semaglutide | GLP-1 | ~15% body weight (STEP-1, 68 wk) | Evidence-backed |
| Zepbound | tirzepatide | GLP-1 / GIP | ~21% body weight (SURMOUNT-1, 72 wk) | Evidence-backed |
| Ozempic | semaglutide | GLP-1 | Same molecule as Wegovy (diabetes label) | Evidence-backed |
| Mounjaro | tirzepatide | GLP-1 / GIP | Same molecule as Zepbound (diabetes label) | Evidence-backed |
| Saxenda | liraglutide | GLP-1 | ~8% body weight (SCALE, daily shot) | Evidence-backed |
| Compounded semaglutide / tirzepatide | semaglutide / tirzepatide | GLP-1 | Same active ingredient; lower cash cost | Evidence-backed |
Older “weight loss shots” — no comparable evidence
| Shot | Active ingredient | Class | Typical result | Verdict |
|---|---|---|---|---|
| B12 (cyanocobalamin) shots | vitamin B12 | Vitamin | No weight-loss effect unless B12-deficient | No evidence |
| Lipotropic / MIC shots | methionine, inositol, choline | Amino/lipotropic | No controlled evidence of fat loss | No evidence |
| HCG shots | human chorionic gonadotropin | Hormone | No substantial evidence per FDA; weight-loss claims prohibited | No evidence |
A B12 injection does nothing for weight unless you were deficient to begin with, and then only at one remove. Nobody has run a controlled trial showing that a lipotropic or MIC shot takes fat off. On HCG, FDA’s position is that no substantial evidence supports it for weight loss, and marketing it that way is not allowed. A clinic selling any of the three as a weight-loss shot has told you something about itself. The longer version: do B12, lipotropic (MIC), and HCG shots work. The GLP-1s are themselves peptides, which is worth reading about separately — peptide shots for weight loss.
The sellers ranked above will prescribe the evidence-backed ones online. If it is the drug rather than the seller you want to understand, start with the semaglutide and tirzepatide guides. The ranked board sits at best weight loss injections.
Detailed Reviews
Trimi Health
Verified partnerBest for: knowing which pharmacy fills the vial: it names VialsRx
Trimi Health is a telehealth seller whose compounded GLP-1 pricing is among the lowest available.
Score Breakdown
Pros
- ✓Semaglutide costs $99 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $125 a month, 50% below the $250 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price stays the same as your dose goes up
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓Names 2 pharmacies that fill its prescriptions, which most sellers do not
- ✓We found no FDA warning letters issued to Trimi Health
Cons
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Embody
Verified partnerBest for: knowing which pharmacy fills the vial: it names RedRock Pharmacy
Embody sells compounded semaglutide and tirzepatide by injection, plus a compounded oral tirzepatide gum that is unique in the category. Flat-rate pricing is aggressive, coverage runs to all 50 states, and clinician messaging is available 24/7 under a board-certified internal medicine CMO.
Score Breakdown
Pros
- ✓Semaglutide costs $79 a month, 57% below the $185 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $129 a month, 48% below the $250 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓Names 4 pharmacies that fill its prescriptions, which most sellers do not
- ✓We found no FDA warning letters issued to Embody
- ✓Offers both oral and injectable options, so the format is your choice
Cons
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
CoreAge Rx
Verified partnerBest for: semaglutide at $99/month, 48% below the typical price
Score breakdown, pros and cons
Shipping is free, 2-day, and reaches all 50 states. CoreAge Rx sells LegitScript-verified compounded semaglutide plus tirzepatide, with licensed physicians behind it and 24/7 support. Its own claim: nobody in the compounded GLP-1 space prices more competitively.
Score Breakdown
Pros
- ✓Semaglutide costs $99 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $149 a month, 40% below the $250 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price stays the same as your dose goes up
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to CoreAge Rx
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
bmiMD
Verified partnerBest for: starting below a standard dose, with microdose tiers
Score breakdown, pros and cons
bmiMD is a medical weight loss clinic that prescribes GLP-1 medications through telehealth.
Score Breakdown
Pros
- ✓Semaglutide costs $99 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $139 a month, 44% below the $250 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price stays the same as your dose goes up
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to bmiMD
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Live Vital
Verified partnerBest for: semaglutide at $99/month, 48% below the typical price
Score breakdown, pros and cons
Billed in 3-month blocks, the compounded GLP-1 semaglutide starts at $99/mo and compounded tirzepatide at $183/mo. Dr. Patrick Taylor, MD founded the practice and every plan is written by a doctor, filled at a licensed US pharmacy and delivered to the door. Messaging the care team has no cap and nothing locks you in. Peptide and hormone therapy round out the menu. Telehealth reaches all 50 states.
Score Breakdown
Pros
- ✓Semaglutide costs $99 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $183 a month, 27% below the $250 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to Live Vital
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its retatrutide, semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
- ✗Its menu lists retatrutide, which FDA says cannot be used in compounding under federal law and has not been found safe and effective for any condition
Which weight loss shots work, and who sells them
Not every injection sold for weight loss has evidence behind it. The GLP-1s, semaglutide and tirzepatide, do. HCG, B12 and lipotropic (MIC) shots do not, whatever the clinic selling them says on its site. Apply that filter first, and what remains is a comparison of GLP-1 sellers.
What to check
- A GLP-1 rather than a vitamin. Not one of B12, lipotropic blends, or HCG produces weight loss on its own. A clinic marketing them for that purpose has told you what kind of clinic it is. Semaglutide and tirzepatide are the injections with results behind them.
- A named pharmacy carrying certification. Where the shot is compounded, one disclosure outweighs the rest: a 503A or 503B pharmacy identified by name, with LegitScript certification attached to it. Nothing else on a marketing page substitutes for that.
- Pricing that survives month one. A cheap opening month that steps up at each dose increase is common in this market, as is a membership charge billed beside the drug. Month two, at full dose, with every recurring line added, is the honest figure.
Red flags
- Pharmacy unnamed and no LegitScript listing. Two disclosures are checkable on any compounded-GLP-1 seller: the 503A or 503B pharmacy filling the vial, and a LegitScript certification. When a site publishes neither, nothing about the contents of that vial can be confirmed from outside.
- Instant approval with no clinician you can reach. A prescriber is supposed to read the intake and stay available once dose questions start. Approval issued automatically, with nobody reachable afterward, means the medical layer was removed rather than streamlined.
- The advertised number is a first month. Headline figures here are usually qualified somewhere. Common forms are an opening rate that steps up with each dose increase, and a membership fee billed separately from the drug itself. Either one can double what leaves your account in month two.
- B12, MIC, or HCG sold for weight loss. Trial evidence for weight loss sits with the GLP-1 injections and nowhere else on this aisle. A clinic that lists lipotropic, B12, or HCG shots under weight loss is selling past the record, whatever its own site says.
Every seller listed above is scored on these criteria under our six-dimension methodology, with prices re-checked against the seller’s own live site.
How we rank, and what counts as “legit”
Scoring for every provider on this page runs against our published six-factor rubric[1]: value, effectiveness, user experience, trust & safety, accessibility and support.
Each of Wegovy, Zepbound, Ozempic and Mounjaro holds its own separate FDA approval under its own NDA number[4][5]. Published Phase 3 efficacy for semaglutide at 2.4 mg (~14.9% mean weight loss across 68 weeks) comes from STEP 1[6]; those for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) come from SURMOUNT-1[7]. In 2025 the SURMOUNT-5 head-to-head set the two against each other[8].
How much of an anti-obesity medication is covered varies widely between state Medicaid programs and between commercial plans[9][10]. Under IRS Publication 502, compounded GLP-1s and brand-name ones alike are generally FSA/HSA eligible where a prescription exists[11].
Frequently Asked Questions
Sources & methodology — as of September 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
- 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
- 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.