Signos Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 6.8/10
Best for: compounded semaglutide at $199/month
Signos' strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
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Covered by the monthly price
Medication
In the price
Clinician visits
Not stated
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Prices checked August 2026
Entry price is $199/mo, and that requires the 6-month plan; shipping is free and HSA/FSA cards work. What Signos+ adds to the prescription is hardware: an app plus a continuous glucose monitor cleared by the FDA, sitting alongside clinician-prescribed compounded semaglutide. Glucose readings arrive in real time with coaching attached, the stated aim being that a user grasps and then holds the loss. Its pitch is that this costs no more than the drug alone.
Is Signos legit?
Yes. Signos is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 6.8/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.
Is there a Signos promo or coupon code?
We know of no promo or coupon code for Signos. Its listed price is $199 a month. Coupon sites advertising "Signos discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.
See how Signos compares on our rankings of the best semaglutide providers and the best tirzepatide providers.
Vetted alternatives to Signos
Enhance MD
Best for: knowing which pharmacy fills the vial: it names Tru Meds Rx
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Signos at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide
- Starting price
- $199/mo
- What's included
- Medication · Shipping
- FDA status
- No FDA warning letters found
How Signos scores
Six columns, each one computed from something Signos has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.
Value25%
4.5/10$199/month is 8% above the $185 median for compounded semaglutide across the sellers we compare.
Effectiveness25%
10.0/10Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).
User Experience15%
8.0/10A price is shown before the questionnaire starts.
Trust & Safety15%
6.5/10No pharmacy is named for its prescriptions. It shows a price before asking for health information.
Accessibility10%
5.0/10No state list is available to check, so this is held at the midpoint rather than scored on reach.
Support10%
4.5/10The price covers the medication and shipping.
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
What we checked on Signos
Last checked August 2026- Checked the listed price across 2 dose or plan tiers
- Checked what the monthly price covers, and what it leaves out
- Checked FDA warning letters for Signos
Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.
What signing up with Signos involves
What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.
- 1Signos shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
- 2Ask Signos which pharmacy fills the prescription before you pay. The pharmacy's name is what lets you check its license.
- 3The monthly price includes the medication and shipping.
- Lowest ongoing monthly price: semaglutide $199. That leaves out membership fees, first-month rates and insurance copays.
- Confirm that Signos serves your state before you start.
- The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.
Cancelling Signos
Taken from the terms Signos publishes. Terms change, so check the current policy before you subscribe.
- Refund policy
- Not published by the seller
GLP-1 medications Signos offers
Each one has its own guide: how the molecule works, the dosing schedule, the side effects that show up in practice, and what the trials actually measured.
Pricing
Prices re-verified
Signos+ GLP-1 bundle (tirzepatide OR semaglutide) from $199/mo; includes CGM system
Check the price yourself before you pay
Every figure here was read off Signos's own checkout on the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.
In its favor
- Semaglutide costs $199 a month, close to the $185 median for compounded semaglutide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication and shipping
- We found no FDA warning letters issued to Signos
Against it
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
What Signos charges
Signos lists $199/month.
- Compounded semaglutide: $199/month
- Compounded tirzepatide: $199/month
For compounded semaglutide, the median across the sellers we compare is $185/month, so Signos' $199 lands mid-market. Price is unlikely to be the deciding factor.
RNK Health dispenses semaglutide and tirzepatide from $197/month, which makes it the fair comparison to run before you commit here.
What Signos dispenses
Signos prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the two best-evidenced weight-loss molecules currently on the market. The medication is compounded rather than dispensed as an approved pen. Compounding serves real clinical needs and is entirely lawful; what it is not is reviewed, and the cost difference reflects that.
Safety and disclosure
Signos tells you its price before you start the medical questionnaire. We found no FDA warning letters issued to Signos. Because the medication is compounded, the most useful question to ask at intake is which licensed pharmacy fills the prescription. If Signos will not tell you, treat that as a warning sign. How we weigh oversight, disclosure and price is set out in our scoring methodology.
Who should look elsewhere
- You want the FDA-approved pen specifically. Everything listed here is compounded.
- You need insurance to cover the cost. Check whether Signos bills your plan before you start.
Our read
Signos lands mid-market on price without a standout advantage or an obvious problem. It comes down to whether its particular package fits you. HumeCare+ is the nearest comparison we review, and worth reading alongside this.
The Bottom Line
Signos' strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
Before you pay Signos
Starting at $199 a month. Check today's price, then start the intake.
Where Signos is the wrong choice
No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.
- If you need the FDA-approved pen rather than a compounded vial, consider Sesame Care.
- If the standing monthly cost is what decides it, consider Collective (from $59/mo).
- If you want a human checking in, not just a prescription, consider Oak.
Compare Signos head to head
The sellers closest to Signos on medication and price.
Frequently Asked Questions
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
Cited across this Signos review: primary regulatory filings, and peer-reviewed studies.
Sources & methodology — as of August 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Signos's current pricing
Plans start at $199 a month. Whether you qualify is a clinician's decision, made after your intake.