Tirzepatide Guide

How Tirzepatide Works

Tirzepatide is a "twincretin". Two incretin receptors switch on together under it: GLP-1, and GIP — glucose-dependent insulinotropic polypeptide. GLP-1 activation reduces appetite and slows gastric emptying, while GIP activation enhances insulin secretion, reduces glucagon, and may also act directly on fat tissue to improve metabolism. This dual mechanism produces greater weight loss than GLP-1-only agents like semaglutide.^[3][5]

Dosing Schedule

Tirzepatide uses a gradual dose escalation to minimize side effects. Always follow your prescriber's guidance and the current FDA label^[1].

Side Effects

Clinical Trial Results

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In the SURMOUNT-1 trial (N=2,539), tirzepatide at the 15mg dose achieved an average weight loss of 22.5% over 72 weeks — nearly double the results seen with semaglutide. Participants on 10mg lost an average of 21.4%, and those on 5mg lost 15.0%, all versus 2.5% placebo.^[3][4]

Where to Get Tirzepatide

Sellers in our register that will dispense tirzepatide, or a compounded version of it, after an online consultation — shipped to your door.

What each seller in the register charges to start on a compounded GLP-1, cheapest at the top. Compounded tirzepatide from licensed 503A and 503B pharmacies is legal under federal compounding law^[6], and the rules have historically loosened further for any molecule sitting on the FDA Drug Shortage List^[7]. An FSA or HSA will generally cover either kind of prescription, compounded or branded, under IRS Publication 502^[8]. What you actually pay moves with your dose and with whatever promotion happens to be running.

Tirzepatide Head-to-Head Comparisons

Short verdict pages setting Tirzepatide against the other GLP-1 options, working from the trial results, the dose ladders on each label, and what the manufacturers charge today.

See all drug-vs-drug verdicts.

Pivotal Tirzepatide Trial Walkthroughs

The trials that produced the Tirzepatide label, taken endpoint by endpoint, with the figures read off the source.

Tirzepatide Patient Questions, Answered

Questions people actually asked about Tirzepatide in named subreddits, each answered from the published trial data.

Ranked PubMed Studies on Tirzepatide

The peer-reviewed studies on Tirzepatide and its neighbours that carry the most weight, gathered into lists. Every PMID was checked against PubMed esummary rather than recalled.

Related Research on Tirzepatide

Longer pieces written here, built on the trial papers themselves, checked against the FDA label, and argued rather than summarized.

Frequently Asked Questions