OneTwenty Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7/10
Best for: people who want a GLP-1 dosed against quarterly lab panels and wearable data
OneTwenty scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on price. Its lowest price, $166 a month, is paid up front.
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charged as a multi-month plan up front
medication only; a membership is required on top
Covered by the monthly price
Medication
Not stated
Clinician visits
Not stated
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
Prices checked November 2026
OneTwenty is a health tracking membership built on four lab panels a year and data from your wearables, with prescriptions from independent telehealth providers as add-ons. Compounded semaglutide is $179 a month and tirzepatide $279, on top of a $499 yearly membership ($749 in New York and New Jersey). Nothing is prescribed until a provider has seen your baseline labs.
Is OneTwenty legit?
Yes. OneTwenty is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 7.0/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.
Is there an OneTwenty promo or coupon code?
We know of no promo or coupon code for OneTwenty. Its listed price is $166 a month for the medication, plus a required membership. Coupon sites advertising "OneTwenty discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.
See how OneTwenty compares on our rankings of the best semaglutide providers and the best tirzepatide providers.
Vetted alternatives to OneTwenty
Embody
Best for: a flat compounded tirzepatide or semaglutide price at every dose, from a seller that names its pharmacies
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
OneTwenty at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $166/mo + membership
- Availability
- 49 states
- FDA status
- No FDA warning letters found
How OneTwenty scores
Six columns, each one computed from something OneTwenty has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.
Value25%
3.0/10The listed figure is not a comparable monthly price for a named GLP-1 (it may be a membership fee, an insured copay, a per-vial rate or a starting-dose price), so Value is capped rather than scored against other sellers.
Effectiveness25%
10.0/10Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).
User Experience15%
7.5/10A price is shown before the questionnaire starts. Baseline bloodwork is required before a prescription.
Trust & Safety15%
7.5/10No pharmacy is named for its prescriptions. It shows a price before asking for health information. It lists the states it serves.
Accessibility10%
9.8/10Serves 49 of 50 states.
Support10%
5.0/10States too little about what the monthly cost covers to score the bundle. Held at the midpoint rather than assumed.
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
What we checked on OneTwenty
Last checked November 2026- Checked the listed price across 4 dose or plan tiers
- Checked state coverage: 49 states
- Checked FDA warning letters for OneTwenty
Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.
What signing up with OneTwenty involves
What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.
- 1OneTwenty shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
- 2The intake requires baseline bloodwork before a first prescription, which takes longer than a written form and is the more careful route.
- 3Ask OneTwenty which pharmacy fills the prescription before you pay. The pharmacy's name is what lets you check its license.
- Before you commit, get the ongoing monthly price of the medication itself, not a first-month rate, a membership fee or a per-vial price.
- OneTwenty serves 49 of 50 states, so check that yours is one of them.
Contacting OneTwenty
- Phone
- 201-540-8754
- OneTwenty offers email support
Cancelling OneTwenty
Taken from the terms OneTwenty publishes. Terms change, so check the current policy before you subscribe.
- Cancel any time
- Yes
- Minimum commitment
- Annual membership (non-refundable after 7 days, auto-renews); medication add-ons bill monthly or quarterly until canceled
- Refund policy
- Payment and Refund Policy: "Cancel within 7 days of purchase, before any service has started, for a refund minus a 3% processing fee. After that, the annual membership is non-refundable." "Medication add-ons are non-refundable once a prescription has been issued."
- Early-termination fee
- None
Medications OneTwenty lists
OneTwenty lists compounded semaglutide and compounded tirzepatide. Each one has its own guide: how it works, the dosing schedule, the side effects that show up in practice, and what the trials measured.
Peptides OneTwenty offers
OneTwenty sells peptides beyond the GLP-1s. Tap one to read what the evidence says about it.
Pricing
Prices re-verified
/treatments/semaglutide: "$179 /month or $499 billed quarterly"; "Semaglutide from ... per month, on top of the annual membership".
"or $499 billed quarterly" ($166.33 a month).
/treatments/tirzepatide: "$279 /month or $749 billed quarterly".
"or $749 billed quarterly" ($249.67 a month).
Check the price yourself before you pay
Every figure here comes from OneTwenty's own website, as of the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.
In its favor
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves 49 states
- We found no FDA warning letters issued to OneTwenty
- Baseline bloodwork is required before a prescription
Against it
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
What OneTwenty charges
OneTwenty lists $166/month for the medication, plus a required membership. Some of OneTwenty's plans are paid several months up front, so read the terms you agree to at checkout before you choose a longer one.
- Compounded semaglutide (monthly): $179/month + membership
- Compounded semaglutide (3-month): $166/month + membership
- Compounded tirzepatide (monthly): $279/month + membership
- Compounded tirzepatide (3-month): $250/month + membership
HealthRX dispenses semaglutide and tirzepatide from $165/month, which makes it the fair comparison to run before you commit here.
What OneTwenty dispenses
OneTwenty prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the pair carrying the strongest published outcome data. The medication is compounded rather than dispensed as an approved pen. Compounding serves real clinical needs and is entirely lawful; what it is not is reviewed, and the cost difference reflects that. The molecule can be the one in Ozempic and Wegovy; what differs is the formulation, the concentration and the dose ladder.
Safety and disclosure
OneTwenty tells you its price before you start the medical questionnaire and the 49 states it serves. We found no FDA warning letters issued to OneTwenty. Because the medication is compounded, the most useful question to ask at intake is which licensed pharmacy fills the prescription. If OneTwenty will not tell you, treat that as a warning sign. A 503A pharmacy answers to a state board and a 503B facility to the FDA; which one fills it changes what you can check. How we weigh oversight, disclosure and price is set out in our scoring methodology.
OneTwenty also sells NAD+, and a 2026 systematic review found no outcomes trials of injected NAD+ for anti-aging or wellness.
Who should look elsewhere
- You want the FDA-approved pen specifically. Everything listed here is compounded.
- You need insurance to cover the cost. Check whether OneTwenty bills your plan before you start.
Our read
OneTwenty charges $166/month for the medication, plus a required membership. Too few sellers offer the same drug and form to say whether that is cheap or expensive, so judge it on what the package includes.
The Bottom Line
OneTwenty scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on price. Its lowest price, $166 a month, is paid up front.
Before you pay OneTwenty
Starting at $166 a month for the medication, plus a required membership. Check today's price, then start the intake.
Where OneTwenty is the wrong choice
No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.
- If you need the FDA-approved pen rather than a compounded vial, consider WellMedRx.
- If the standing monthly cost is what decides it, consider Collective (from $59/mo + membership).
- If you want a human checking in, not just a prescription, consider Eden.
If none of these fits, our guide to alternatives to OneTwenty sets more sellers in the same category beside OneTwenty on price, states and what the price includes.
Frequently Asked Questions
How to check OneTwenty yourself
- Buying Tirzepatide as a Research Chemical: What "Research Use Only" Really Means
- How to Get a GLP-1 Prescription
- Is Ozempic Available Over the Counter? No GLP-1 Is, and What Is Sold Instead
Every seller that ships to your state, side by side: Alabama, Idaho, Kentucky, Montana, New Hampshire, New Mexico, North Dakota, Oklahoma and every other state.
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
Cited across this OneTwenty review: primary regulatory filings, and peer-reviewed studies.
Sources & methodology — as of November 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.
See OneTwenty's current pricing
Plans start at $166 a month for the medication, plus a required membership. Whether you qualify is a clinician's decision, made after your intake.