Semaglutide Guide

How Semaglutide Works

Semaglutide mimics the naturally occurring hormone GLP-1 (glucagon-like peptide-1), which is released after eating. It activates GLP-1 receptors in the brain to reduce appetite and increase feelings of fullness, while also slowing gastric emptying so food stays in the stomach longer. These combined effects lead to reduced caloric intake and meaningful, sustained weight loss.^[3][6]

Dosing Schedule

Semaglutide uses a gradual dose escalation to minimize side effects. Always follow your prescriber's guidance and the current FDA label^[1].

Side Effects

Clinical Trial Results

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STEP-1 (N=1,961) is the landmark result: over 68 weeks, adults on semaglutide 2.4mg shed a mean 14.9% of body weight where the placebo group shed 2.4%. Measured against the 5%-of-body-weight bar, 86.4% of the treated arm cleared it and 31.5% of the placebo arm did.^[3][4][5]

Where to Get Semaglutide

Sellers in our register that will dispense semaglutide, or a compounded version of it, after an online consultation — shipped to your door.

What each seller in the register charges to start on a compounded GLP-1, cheapest at the top. Compounded semaglutide from licensed 503A and 503B pharmacies is legal under federal compounding law^[7], and the rules have historically loosened further for any molecule sitting on the FDA Drug Shortage List^[8]. An FSA or HSA will generally cover either kind of prescription, compounded or branded, under IRS Publication 502^[9]. What you actually pay moves with your dose and with whatever promotion happens to be running.

Semaglutide Head-to-Head Comparisons

Short verdict pages setting Semaglutide against the other GLP-1 options, working from the trial results, the dose ladders on each label, and what the manufacturers charge today.

See all drug-vs-drug verdicts.

Pivotal Semaglutide Trial Walkthroughs

The trials that produced the Semaglutide label, taken endpoint by endpoint, with the figures read off the source.

Semaglutide Patient Questions, Answered

Questions people actually asked about Semaglutide in named subreddits, each answered from the published trial data.

Semaglutide Reference Cards

One-screen references for the dose schedule, what to do about a missed dose, and the side effects that warrant a call. Every figure checked against the DailyMed label.

Ranked PubMed Studies on Semaglutide

The peer-reviewed studies on Semaglutide and its neighbours that carry the most weight, gathered into lists. Every PMID was checked against PubMed esummary rather than recalled.

Related Research on Semaglutide

Longer pieces written here, built on the trial papers themselves, checked against the FDA label, and argued rather than summarized.

Frequently Asked Questions