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Onyx Weight Loss Review

Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 6.2/10

Best for: patients in its 9 states who want labs and monthly NP follow-ups bundled into one price

6.2
★★★☆☆6.2/10

Onyx Weight Loss scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on price, and it serves 9 states. Its compounded semaglutide costs $349 a month, 75% above the $199 median among the sellers we compare.

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$349/mo

Covered by the monthly price

Medication

In the price

Clinician visits

Not stated

Shipping

In the price

Lab work

In the price

Coaching

Not stated

See plans →

Prices checked October 2026

Compare top-rated alternatives ↓

Onyx Weight Loss is a virtual clinic run by nurse practitioners out of Mooresville, NC, founded by Tasha Vangile FNP-C and Madalyn Vangile RN. Its monthly GLP-1 injection membership costs $349 and the GLP-1/GIP membership starts at $399, with medication, required labs, follow-ups and shipping included. Sublingual and 10-week plans are also sold. It serves 9 states, with hormone care and peptides alongside, and names Strive Pharmacy as its pharmacy partner.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed
GLP-1 from $349/moPrice shown up frontIncludes medication + shipping9 statesPharmacy namedNo FDA warning letters found

Is Onyx Weight Loss legit?

Yes. Onyx Weight Loss is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 6.2/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.

Is there an Onyx Weight Loss promo or coupon code?

We know of no promo or coupon code for Onyx Weight Loss. Its listed price is $349 a month. Coupon sites advertising "Onyx Weight Loss discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.

See how Onyx Weight Loss compares on our rankings of the best semaglutide providers and the best tirzepatide providers.

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★★★★★9.0/10

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Best for: seeing what it charges before you answer any medical questions

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Onyx Weight Loss logo
6.2 / 10
Our editorial rating
Visit Onyx Weight Loss →

from $349/mo · no insurance needed

Onyx Weight Loss at a glance

Type
GLP-1 telehealth provider
Medications
Semaglutide, Tirzepatide
Starting price
$349/mo
What's included
Medication · Labs · Shipping
Availability
9 states
FDA status
No FDA warning letters found

How Onyx Weight Loss scores

Six columns, each one computed from something Onyx Weight Loss has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.

Value25%

0.9/10

$349/month is 75% above the $199 median for compounded semaglutide across the sellers we compare.

Effectiveness25%

10.0/10

Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).

User Experience15%

8.0/10

A price is shown before the questionnaire starts.

Trust & Safety15%

9.0/10

It names the pharmacy that fills its prescriptions. It shows a price before asking for health information. It lists the states it serves.

Accessibility10%

3.4/10

Serves 9 of 50 states.

Support10%

6.0/10

The price covers the medication, shipping and lab work.

6weighted dimensions
734sellers compared
Everychecked against the seller's own site
Value 25%Effectiveness 25%User Experience 15%Trust & Safety 15%Accessibility 10%Support 10%

A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →

What we checked on Onyx Weight Loss

Last checked October 2026
  • Checked the listed price across 4 dose or plan tiers
  • Checked state coverage: 9 states
  • Checked what the monthly price covers, and what it leaves out
  • Recorded which pharmacies the seller names as filling its prescriptions, with the page and date
  • Checked FDA warning letters for Onyx Weight Loss

Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.

What signing up with Onyx Weight Loss involves

What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.

  1. 1Onyx Weight Loss shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
  2. 2Strive Pharmacy fills the prescriptions, and Onyx Weight Loss names it publicly, which most sellers do not.
  3. 3The monthly price includes the medication, shipping and lab work.
Price shown before you start
  • Lowest ongoing monthly price: semaglutide $349, tirzepatide $499. That leaves out membership fees, first-month rates and insurance copays.
  • Onyx Weight Loss serves 9 of 50 states, so check that yours is one of them.
  • The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.

Contacting Onyx Weight Loss

Phone
(704) 659-4633

Cancelling Onyx Weight Loss

Taken from the terms Onyx Weight Loss publishes. Terms change, so check the current policy before you subscribe.

Cancel any time
Yes
Minimum commitment
None on the monthly membership
Refund policy
Not published by the seller
Early-termination fee
None

Medications Onyx Weight Loss lists

Onyx Weight Loss lists compounded semaglutide and compounded tirzepatide. Each one has its own guide: how it works, the dosing schedule, the side effects that show up in practice, and what the trials measured.

Semaglutide(compounded)Tirzepatide(compounded)

Peptides Onyx Weight Loss offers

Onyx Weight Loss sells peptides beyond the GLP-1s. Tap one to read what the evidence says about it.

LeafGHK-CuSkin & hair repairDropletGlutathioneAntioxidant infusionsDropletNAD+Energy & cellular agingHeartPT-141Desire & arousalSyringeSermorelinOwn growth-hormone output

Pricing

Prices re-verified

GLP-1 injection, billed monthlyCompounded
$349/mo
semaglutide

Covers a month of medication, a follow-up visit each month, required labs and shipping. 10-week Flex Plan from $559; Starter 10-week plan $569.

GLP-1 sublingual, billed monthly (starting)Compounded
$399/mo
semaglutide

Taken daily under the tongue. Labs, shipping and a visit each month are covered.

GLP-1/GIP injection, billed monthly (starting)Compounded
$399/mo
tirzepatide

Covers a month of medication, a follow-up visit each month, required labs and shipping. 10-week Flex Plan from $589; Starter 10-week plan $709.

GLP-1/GIP sublingual, billed monthlyCompounded
$499/mo
tirzepatide

Taken daily under the tongue. Labs, shipping and a visit each month are covered.

Check the price yourself before you pay

Every figure here comes from Onyx Weight Loss's own website, as of the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.

See Onyx Weight Loss pricing →

Onyx Weight Loss compounding-pharmacy partners

Onyx Weight Loss names each pharmacy below as one that compounds or fills its prescriptions, in its own site, terms or filings. The quote under each one is the seller’s own wording.

Compare every compounding pharmacy we’ve reviewed →

In its favor

  • Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • The monthly price includes the medication, shipping and lab work
  • Names Strive Pharmacy as the pharmacy that fills its prescriptions, which most sellers do not
  • We found no FDA warning letters issued to Onyx Weight Loss

Against it

  • Semaglutide costs $349 a month, 75% above the $199 median for compounded semaglutide across the sellers we compare
  • Tirzepatide costs $499 a month, 86% above the $269 median for compounded tirzepatide across the sellers we compare
  • Serves only 9 states, so check that yours is one of them
  • Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality

What Onyx Weight Loss charges

Onyx Weight Loss charges $349/month. That sits above the middle of the market, which puts the burden on whatever else is in the package.

  • Compounded semaglutide (injection): $349/month
  • Compounded semaglutide (sublingual): $399/month
  • Compounded tirzepatide (injection): $399/month
  • Compounded tirzepatide (sublingual): $499/month

For compounded semaglutide, the median across the sellers we compare is $199/month, so Onyx Weight Loss' $349 is a premium, and a premium has to buy something. Check what is bundled before you accept it. Before you pay, compare Onyx Weight Loss' cancellation terms with other sellers' cancellation and refund policies.

MangoRx dispenses semaglutide and tirzepatide from $299/month, which makes it the fair comparison to run before you commit here.

What Onyx Weight Loss dispenses

Onyx Weight Loss prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the two molecules with the largest published weight-loss trial programs behind them. What arrives is compounded at a licensed pharmacy, not an approved pen. That is the reason it costs less, and the reason the finished preparation carries no FDA review behind it. The molecule can be the one in Ozempic and Wegovy; what differs is the formulation, the concentration and the dose ladder.

A needle-free oral option is genuinely uncommon and is the reason some readers will look at Onyx Weight Loss at all. Set expectations on the evidence, though: the published weight-loss trials for these molecules used injections. Oral and sublingual delivery of peptides is far less studied, so treat it as a route that solves the needle problem rather than as a proven equal to the shot. No human absorption study of sublingual semaglutide drops has been published.

Safety and disclosure

Onyx Weight Loss tells you its price before you start the medical questionnaire, the 9 states it serves, and the pharmacy that fills its prescriptions. We found no FDA warning letters issued to Onyx Weight Loss. Because the medication is compounded, the named pharmacy is the detail that matters most: its license is the one you can look up. The FDA's warning signs for online medicine sellers are a quick check to run on any seller before you pay. How we weigh oversight, disclosure and price is set out in our scoring methodology.

Onyx Weight Loss also sells NAD+, and a 2026 systematic review found no outcomes trials of injected NAD+ for anti-aging or wellness.

Who should look elsewhere

  • You care most about the twelve-month total, not the first bill. A flat-rate seller such as Collective will usually win that math.
  • You want the FDA-approved pen specifically. Everything listed here is compounded.
  • You need insurance to cover the cost. Check whether Onyx Weight Loss bills your plan before you start.

It fits if

  • injections are the thing keeping you from starting

Our read

Onyx Weight Loss costs more than the middle of this market, and the oral option is the clearest thing that premium buys. If the extras it charges for are ones you would actually use, that is a defensible trade. If not, the same molecule is available for less.

The Bottom Line

Onyx Weight Loss scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on price, and it serves 9 states. Its compounded semaglutide costs $349 a month, 75% above the $199 median among the sellers we compare.

Score: 6.2/10Best for: patients in its 9 states who want labs and monthly NP follow-ups bundled into one priceFrom: $349/mo

Before you pay Onyx Weight Loss

Starting at $349 a month. Check today's price, then start the intake.

Visit Onyx Weight Loss →

Where Onyx Weight Loss is the wrong choice

No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.

  • If you need the FDA-approved pen rather than a compounded vial, consider WellMedRx.
  • If the standing monthly cost is what decides it, consider Collective (from $59/mo + membership).
  • If you want a human checking in, not just a prescription, consider Eden.

If none of these fits, our guide to alternatives to Onyx Weight Loss sets more sellers in the same category beside Onyx Weight Loss on price, states and what the price includes.

Frequently Asked Questions

Onyx Weight Loss is a virtual clinic run by nurse practitioners out of Mooresville, NC, founded by Tasha Vangile FNP-C and Madalyn Vangile RN. Its monthly GLP-1 injection membership costs $349 and the GLP-1/GIP membership starts at $399, with medication, required labs, follow-ups and shipping included. Sublingual and 10-week plans are also sold. It serves 9 states, with hormone care and peptides alongside, and names Strive Pharmacy as its pharmacy partner. We rate it 6.2/10 overall.
Onyx Weight Loss starts at $349 a month. The pricing table above lists every tier.
Onyx Weight Loss names 9 states. Check that yours is on the list before you go any further.
Onyx Weight Loss lists compounded semaglutide and compounded tirzepatide. A needle-free oral form is listed as well.
Onyx Weight Loss lists compounded GLP-1s only. A licensed compounding pharmacy prepares them: same active ingredient as the brand drug, lower cash price, and no FDA approval of the finished product. That last part is the one readers underestimate, and the review above says why.
Check whether Onyx Weight Loss bills your insurance before you sign up. Compounded GLP-1s are rarely covered by insurance, so plan on paying the listed cash price.
Onyx Weight Loss says the price covers medication, shipping and lab work. The strip near the top of this review shows what is included and what is not.
You fill in an online intake, a licensed clinician decides whether a GLP-1 is appropriate, and if the answer is yes the medication ships to you. Onyx Weight Loss runs that whole sequence on its own site.
We found no FDA warning letters issued to Onyx Weight Loss. Before you buy, weigh these: Semaglutide costs $349 a month, 75% above the $199 median for compounded semaglutide across the sellers we compare. Tirzepatide costs $499 a month, 86% above the $269 median for compounded tirzepatide across the sellers we compare. Serves only 9 states, so check that yours is one of them. None of them rules Onyx Weight Loss out, but each is worth settling before you pay.
Other sellers we cover include MangoRx, TrimRx, and RxSpan MD. Which one fits depends on the medication, the monthly price you can sustain and whether it ships to your state, so compare those three facts before you switch.

How to check Onyx Weight Loss yourself

Every seller that ships to your state, side by side: Colorado, Iowa, Maine, Nebraska, New Hampshire, North Carolina, Vermont, Virginia and every other state.

Glossary

The words sellers use, defined. Tap any term.

Sources

Cited across this Onyx Weight Loss review: primary regulatory filings, and peer-reviewed studies.

Sources & methodology — as of October 2026
  1. 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
  5. 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  8. 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  9. 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  10. 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  11. 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  12. 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.

See Onyx Weight Loss's current pricing

Plans start at $349 a month. Whether you qualify is a clinician's decision, made after your intake.

Visit Onyx Weight Loss →