Onyx Weight Loss Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 8.2/10
Best for: starting below a standard dose, with microdose tiers
Onyx Weight Loss' strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
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Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Prices checked August 2026
GLP-1 (semaglutide-type) plans begin at $228/month; GLP-1/GIP (tirzepatide-type) plans at $280/month. There is also a $99/month GLP-1 microdosing option for anyone wanting a gradual-titration start. Onyx Weight Loss runs a nurse-practitioner-led telehealth clinic out of Mooresville, NC, set up by Madalyn Vangile RN and Tasha Vangile FNP-C, and it covers 8 states with HRT and peptides sold beside the GLP-1s. Its partner Strive Pharmacy ships medication and supplies home.
Is Onyx Weight Loss legit?
Yes. Onyx Weight Loss is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 8.2/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.
Is there an Onyx Weight Loss promo or coupon code?
We know of no promo or coupon code for Onyx Weight Loss. Its listed price is $99 a month. Coupon sites advertising "Onyx Weight Loss discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.
See how Onyx Weight Loss compares on our rankings of the best semaglutide providers and the best tirzepatide providers.
Vetted alternatives to Onyx Weight Loss
Trimi Health
Best for: knowing which pharmacy fills the vial: it names VialsRx
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Onyx Weight Loss at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $99/mo
- What's included
- Medication · Consult · Shipping
- Availability
- 8 states
- FDA status
- No FDA warning letters found
How Onyx Weight Loss scores
Six columns, each one computed from something Onyx Weight Loss has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.
Value25%
9.5/10$99/month is 46% below the $185 median for compounded semaglutide across the sellers we compare.
Effectiveness25%
10.0/10Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).
User Experience15%
8.0/10A price is shown before the questionnaire starts.
Trust & Safety15%
7.5/10No pharmacy is named for its prescriptions. It shows a price before asking for health information. It lists the states it serves.
Accessibility10%
3.3/10Serves 8 of 50 states.
Support10%
7.0/10The price covers the medication, clinician visits and shipping.
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
What we checked on Onyx Weight Loss
Last checked August 2026- Checked the listed price across 3 dose or plan tiers
- Checked state coverage: 8 states
- Checked what the monthly price covers, and what it leaves out
- Checked FDA warning letters for Onyx Weight Loss
Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.
What signing up with Onyx Weight Loss involves
What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.
- 1Onyx Weight Loss shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
- 2Ask Onyx Weight Loss which pharmacy fills the prescription before you pay. The pharmacy's name is what lets you check its license.
- 3The monthly price includes the medication, clinician visits and shipping.
- Lowest ongoing monthly price: semaglutide $99. That leaves out membership fees, first-month rates and insurance copays.
- Onyx Weight Loss serves 8 of 50 states, so check that yours is one of them.
- The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.
Contacting Onyx Weight Loss
- Phone
- (704) 659-4633
GLP-1 medications Onyx Weight Loss offers
Each one has its own guide: how the molecule works, the dosing schedule, the side effects that show up in practice, and what the trials actually measured.
Peptides Onyx Weight Loss offers
Onyx Weight Loss sells peptides beyond the GLP-1s. Tap one to read what the evidence says about it.
Pricing
Prices re-verified
'Starting at $228/month' on the GLP-1 Agonist plan, including medication and supplies shipped home. Entry tier only; higher-dose prices are not published.
'Starting at $280/month' on the GLP-1/GIP Agonist plan, including medication and supplies. Entry tier only. Onyx does not name the drug beyond 'GLP-1/GIP.'
$99/month on the GLP-1 Microdosing plan, a low-dose, gradual-start option.
Check the price yourself before you pay
Every figure here was read off Onyx Weight Loss's own checkout on the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.
In its favor
- Semaglutide costs $99 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
- We found no FDA warning letters issued to Onyx Weight Loss
Against it
- Serves only 8 states, so check that yours is one of them
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
What Onyx Weight Loss charges
Onyx Weight Loss charges $99/month. That sits at the affordable end of what we see.
- Compounded semaglutide: $228/month
- Compounded tirzepatide: $280/month
- Compounded semaglutide: $99/month
For compounded semaglutide, the median across the sellers we compare is $185/month, so Onyx Weight Loss' $99 is genuinely below the middle, not just advertised that way.
bmiMD, at about $99/month, is the closest like-for-like alternative we review.
What Onyx Weight Loss dispenses
Onyx Weight Loss prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the two molecules with the largest published weight-loss trial programs behind them. What arrives is compounded at a licensed pharmacy, not an approved pen. That is the reason it costs less, and the reason the finished preparation carries no FDA review behind it.
Safety and disclosure
Onyx Weight Loss tells you its price before you start the medical questionnaire and the 8 states it serves. We found no FDA warning letters issued to Onyx Weight Loss. Because the medication is compounded, the most useful question to ask at intake is which licensed pharmacy fills the prescription. If Onyx Weight Loss will not tell you, treat that as a warning sign. How we weigh oversight, disclosure and price is set out in our scoring methodology.
Who should look elsewhere
- You want the FDA-approved pen specifically. Everything listed here is compounded.
- You need insurance to cover the cost. Check whether Onyx Weight Loss bills your plan before you start.
It fits if
- the lowest standing monthly cost is what you are solving for
Our read
Onyx Weight Loss competes on price without an obvious sacrifice elsewhere: $99/month, no FDA warning letters.
The Bottom Line
Onyx Weight Loss' strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
Before you pay Onyx Weight Loss
Starting at $99 a month. Check today's price, then start the intake.
Where Onyx Weight Loss is the wrong choice
No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.
- If you need the FDA-approved pen rather than a compounded vial, consider Sesame Care.
- If the standing monthly cost is what decides it, consider Collective (from $59/mo).
- If you want a human checking in, not just a prescription, consider ShedRx.
Compare Onyx Weight Loss head to head
The sellers closest to Onyx Weight Loss on medication and price.
Frequently Asked Questions
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
Cited across this Onyx Weight Loss review: primary regulatory filings, and peer-reviewed studies.
Sources & methodology — as of August 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See Onyx Weight Loss's current pricing
Plans start at $99 a month. Whether you qualify is a clinician's decision, made after your intake.