The Protocole Review
Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 7.1/10
Best for: people who want compounded semaglutide or tirzepatide bought one month at a time, with no subscription
The Protocole's strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
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Covered by the monthly price
Medication
In the price
Clinician visits
Not stated
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
Prices checked October 2026
The Protocole is a New York peptide membership service from PeptideCo, Inc. that sells compounded semaglutide and tirzepatide alongside NAD+, glutathione and sermorelin. It names its medical group and its single pharmacy, and sells each 4-week supply as a one-off order rather than a subscription. Semaglutide is $279 per 4-week supply and tirzepatide $329; the terms also mention a one-time membership fee that the site never prices.
Is The Protocole legit?
Yes. The Protocole is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 7.1/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.
Is there a The Protocole promo or coupon code?
We know of no promo or coupon code for The Protocole. Its listed price is $279 a month. Coupon sites advertising "The Protocole discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.
See how The Protocole compares on our rankings of the best semaglutide providers and the best tirzepatide providers.
Vetted alternatives to The Protocole
CoreAge Rx
Best for: flat-priced compounded semaglutide at $79 a month, any dose
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
The Protocole at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Semaglutide, Tirzepatide
- Starting price
- $279/mo
- What's included
- Medication
- Availability
- All 50 states
- FDA status
- No FDA warning letters found
How The Protocole scores
Six columns, each one computed from something The Protocole has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.
Value25%
3.0/10$329/month is 32% above the $249 median for compounded tirzepatide across the sellers we compare.
Effectiveness25%
10.0/10Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).
User Experience15%
8.0/10A price is shown before the questionnaire starts.
Trust & Safety15%
7.5/10No pharmacy is named for its prescriptions. It shows a price before asking for health information. It lists the states it serves.
Accessibility10%
10.0/10Serves all 50 states.
Support10%
5.0/10States too little about what the monthly cost covers to score the bundle. Held at the midpoint rather than assumed.
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
What we checked on The Protocole
Last checked October 2026- Checked the listed price across 2 dose or plan tiers
- Checked state coverage: all 50
- Checked what the monthly price covers, and what it leaves out
- Checked FDA warning letters for The Protocole
Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.
What signing up with The Protocole involves
What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.
- 1The Protocole shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
- 2Ask The Protocole which pharmacy fills the prescription before you pay. The pharmacy's name is what lets you check its license.
- 3The monthly price includes the medication.
- Lowest ongoing monthly price: semaglutide $279, tirzepatide $329. That leaves out membership fees, first-month rates and insurance copays.
- The Protocole serves all 50 states.
- The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.
Contacting The Protocole
- Phone
- +1 (332) 239-4430
- The Protocole offers email support
Cancelling The Protocole
Taken from the terms The Protocole publishes. Terms change, so check the current policy before you subscribe.
- Cancel any time
- Yes
- Minimum commitment
- No subscription. Each 4-week supply is a separate order; the terms say medication may be bought as needed
- Refund policy
- Money back in full for a declined applicant, or for a cancellation made before any clinical work starts; after that point, "all sales are final."
Medications The Protocole lists
The Protocole lists compounded semaglutide and compounded tirzepatide. Each one has its own guide: how it works, the dosing schedule, the side effects that show up in practice, and what the trials measured.
Pricing
Prices re-verified
$279 for a 4-week supply. A lower-dose microdose version is $179 per 4-week supply. The terms add a one-time membership initiation fee with no amount published.
$329 for a 4-week supply. A microdose version is $229 per 4-week supply.
Check the price yourself before you pay
Every figure here was read off The Protocole's own checkout on the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.
In its favor
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication
- Serves all 50 states
- We found no FDA warning letters issued to The Protocole
Against it
- Semaglutide costs $279 a month, 40% above the $199 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $329 a month, 32% above the $249 median for compounded tirzepatide across the sellers we compare
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
What The Protocole charges
The Protocole lists $279/month.
- Compounded semaglutide: $279/month
- Compounded tirzepatide: $329/month
For compounded tirzepatide, the median across the sellers we compare is $249/month, so The Protocole's $329 is a premium, and a premium has to buy something. Check what is bundled before you accept it.
Direct Meds dispenses semaglutide and tirzepatide from $249/month, which makes it the fair comparison to run before you commit here.
What The Protocole dispenses
The Protocole prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the pair carrying the strongest published outcome data. What arrives is compounded at a licensed pharmacy, not an approved pen. That is the reason it costs less, and the reason the finished preparation carries no FDA review behind it.
Safety and disclosure
The Protocole tells you its price before you start the medical questionnaire and that it treats patients in all 50 states. We found no FDA warning letters issued to The Protocole. Because the medication is compounded, the most useful question to ask at intake is which licensed pharmacy fills the prescription. If The Protocole will not tell you, treat that as a warning sign. How we weigh oversight, disclosure and price is set out in our scoring methodology.
Who should look elsewhere
- You care most about the twelve-month total, not the first bill. A flat-rate seller such as Collective will usually win that math.
- You want the FDA-approved pen specifically. Everything listed here is compounded.
- You need insurance to cover the cost. Check whether The Protocole bills your plan before you start.
It fits if
- you need access wherever you live
Our read
The Protocole costs more than the middle of this market. If the extras it charges for are ones you would actually use, that is a defensible trade. If not, the same molecule is available for less. MangoRx is the nearest comparison we review, and worth reading alongside this.
The Bottom Line
The Protocole's strongest column is the clinical side: which molecules it will prescribe, and how it handles dosing.
Before you pay The Protocole
Starting at $279 a month. Check today's price, then start the intake.
Where The Protocole is the wrong choice
No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.
- If you need the FDA-approved pen rather than a compounded vial, consider SkinnyRx.
- If the standing monthly cost is what decides it, consider Collective (from $59/mo).
- If you want a human checking in, not just a prescription, consider ShedRx.
Compare The Protocole head to head
The sellers closest to The Protocole on medication and price.
Frequently Asked Questions
How to check The Protocole yourself
- How to Verify an Online GLP-1 Pharmacy: Six Public Checks
- We Read FDA's Register of Compounding Facilities. 42 of 98 Have Never Been Inspected.
- Buying Tirzepatide as a Research Chemical: What "Research Use Only" Really Means
Every seller that ships to your state, side by side: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware and every other state.
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
Cited across this The Protocole review: primary regulatory filings, and peer-reviewed studies.
Sources & methodology — as of October 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.
See The Protocole's current pricing
Plans start at $279 a month. Whether you qualify is a clinician's decision, made after your intake.