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Rx.com Review

Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 8.2/10

Best for: flat any-dose compounded GLP-1 pricing with the dispensing pharmacy named up front

8.2
★★★★☆8.2/10

Rx.com scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on follow-up care. It charges from $99 a month, paid up front; its compounded semaglutide, at $175, is 12% below the $199 median among the sellers we compare.

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$99/mo

charged as a multi-month plan up front

Same price at every dose

Covered by the monthly price

Medication

In the price

Clinician visits

In the price

Shipping

In the price

Lab work

Not stated

Coaching

Not stated

See plans →

Prices checked October 2026

Compare top-rated alternatives ↓

Rx.com, a prescription discount-card site, also runs its own online weight-loss program selling compounded semaglutide and tirzepatide through the MD Integrations provider network. It names its dispensing pharmacy and charges one flat price at every dose, with the provider visit, supplies and shipping included. A month at a time costs $175 for semaglutide and $285 for tirzepatide; a 12-month plan billed in one charge brings that to $99 and $149 a month.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed
Price shown up frontFlat across dosesIncludes medication + consult47 statesPharmacy namedNo FDA warning letters found

Is Rx.com legit?

Yes. Rx.com is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 8.2/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.

Is there a Rx.com promo or coupon code?

We know of no promo or coupon code for Rx.com. Its listed price is $99 a month. Coupon sites advertising "Rx.com discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.

See how Rx.com compares on our rankings of the best semaglutide providers and the best tirzepatide providers.

Vetted alternatives to Rx.com

9.3/ 10
Verified partner

Embody

Best for: a flat compounded tirzepatide or semaglutide price at every dose, from a seller that names its pharmacies

★★★★★9.3/10

Editorial score · methodology

$79/mo
CompoundedSemaglutideTirzepatideGlutathioneNAD+
Get StartedRead full Embody review →
8.7/ 10
Verified partner

Eden

Best for: coverage in all 50 states, which most sellers will not confirm

★★★★☆8.7/10

Editorial score · methodology

$99/mo
CompoundedSemaglutideTirzepatideGHK-CuGlutathione
Get StartedRead full Eden review →
6.6/ 10
Verified partner

HumeCare+

Best for: an oral route if you will not self-inject

★★★☆☆6.6/10

Editorial score · methodology

$199/mo
CompoundedSemaglutideTirzepatide
Get StartedRead full HumeCare+ review →
Rx.com logo
8.2 / 10
Our editorial rating
Visit Rx.com →

from $99/mo · no insurance needed

Rx.com at a glance

Type
GLP-1 telehealth provider
Medications
Semaglutide, Tirzepatide
Starting price
$99/mo
Pricing model
Flat: the price stays the same as the dose goes up
What's included
Medication · Consult · Shipping
Availability
47 states
FDA status
No FDA warning letters found

How Rx.com scores

Six columns, each one computed from something Rx.com has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.

Value25%

5.9/10

$175/month is 12% below the $199 median for compounded semaglutide across the sellers we compare. A cheaper plan paid several months up front is also listed.

Effectiveness25%

10.0/10

Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).

User Experience15%

8.0/10

A price is shown before the questionnaire starts.

Trust & Safety15%

9.0/10

It names the pharmacy that fills its prescriptions. It shows a price before asking for health information. It lists the states it serves.

Accessibility10%

9.5/10

Serves 47 of 50 states.

Support10%

7.0/10

The price covers the medication, clinician visits and shipping.

6weighted dimensions
734sellers compared
Everychecked against the seller's own site
Value 25%Effectiveness 25%User Experience 15%Trust & Safety 15%Accessibility 10%Support 10%

A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →

What we checked on Rx.com

Last checked October 2026
  • Checked the listed price across 4 dose or plan tiers
  • Checked state coverage: 47 states
  • Checked what the monthly price covers, and what it leaves out
  • Recorded which pharmacies the seller names as filling its prescriptions, with the page and date
  • Checked FDA warning letters for Rx.com

Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.

What signing up with Rx.com involves

What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.

  1. 1Rx.com shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
  2. 2Manifest Pharmacy fills the prescriptions, and Rx.com names it publicly, which most sellers do not.
  3. 3The monthly price includes the medication, clinician visits and shipping.
Price shown before you start
  • Lowest ongoing monthly price: semaglutide $99, tirzepatide $149. That leaves out membership fees, first-month rates and insurance copays.
  • Rx.com serves 47 of 50 states, so check that yours is one of them.
  • The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.

Contacting Rx.com

Phone
1-726-201-0849
Email
Rx.com offers email support
Hours
Monday-Friday, 8am-5pm Eastern Time

Cancelling Rx.com

Taken from the terms Rx.com publishes. Terms change, so check the current policy before you subscribe.

Cancel any time
Yes
Minimum commitment
1, 3, 6 or 12-month plans; checkout shows the 12-month plan 'Billed every 12 months' while the program page says plans do not renew automatically
Refund policy
Once charged and handed to the carrier, "all sales are final"; a full refund if a provider determines treatment is not clinically appropriate
Early-termination fee
None

Medications Rx.com lists

Rx.com lists compounded semaglutide and compounded tirzepatide. Each one has its own guide: how it works, the dosing schedule, the side effects that show up in practice, and what the trials measured.

Semaglutide(compounded)Tirzepatide(compounded)

Pricing

Prices re-verified

Weekly injection, 1-month plan (same price at every dose)Compounded
$175/mo
semaglutide

The 1-month plan is $175. The checkout plan picker lists $165/mo on a 3-month plan, $146/mo on a 6-month plan and $99/mo on a 12-month plan. The provider visit, medication, supplies and shipping are included.

12-month plan (48 weekly doses in one shipment), $1,188 billed every 12 monthsCompounded
$99/mo
semaglutide

Charged only if a provider prescribes. Same price at every dose.

Weekly injection, 1-month plan (same price at every dose)Compounded
$285/mo
tirzepatide

The 1-month plan is $285. The checkout plan picker lists $265/mo on a 3-month plan, $258/mo on a 6-month plan and $149/mo on a 12-month plan. The provider visit, medication, supplies and shipping are included.

12-month plan (48 weekly doses in one shipment), $1,788 billed every 12 monthsCompounded
$149/mo
tirzepatide

Charged only if a provider prescribes. Same price at every dose.

Check the price yourself before you pay

Every figure here comes from Rx.com's own website, as of the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.

See Rx.com pricing →

Rx.com compounding-pharmacy partners

Rx.com names each pharmacy below as one that compounds or fills its prescriptions, in its own site, terms or filings. The quote under each one is the seller’s own wording.

Manifest Pharmacy

“Prescriptions ordered through the weight-loss program are dispensed by Manifest Pharmacy, 1018 S. Batesville Road, Greer, SC 29650, 888-770-4009, Monday-Friday 8:00am-5:00pm EST.”

Compare every compounding pharmacy we’ve reviewed →

In its favor

  • Semaglutide costs $175 a month, 12% below the $199 median for compounded semaglutide across the sellers we compare
  • Tirzepatide costs $285 a month, close to the $269 median for compounded tirzepatide across the sellers we compare
  • Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • The monthly price stays the same as your dose goes up
  • The monthly price includes the medication, clinician visits and shipping
  • Serves 47 states
  • Names Manifest Pharmacy as the pharmacy that fills its prescriptions, which most sellers do not
  • We found no FDA warning letters issued to Rx.com

Against it

  • Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality

What Rx.com charges

Rx.com lists $99/month, flat regardless of dose. Flat dose pricing matters more than it sounds: on a tiered plan the bill grows with the dose, so the figure that got you to sign up is not the one you end up paying.

  • Compounded semaglutide (injection): $175/month
  • Compounded semaglutide: $99/month
  • Compounded tirzepatide (injection): $285/month
  • Compounded tirzepatide: $149/month

For compounded semaglutide, the median across the sellers we compare is $199/month, so Rx.com's $175 is genuinely below the middle, not just advertised that way. Some of Rx.com's plans are paid several months up front, so read the terms you agree to at checkout before you choose a longer one. For scale, the dearest tenth of compounded sellers charges about three times the cheapest tenth.

AgelessRx, at about $99/month, is the closest like-for-like alternative we review.

What Rx.com dispenses

Rx.com prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the pair carrying the strongest published outcome data. What arrives is compounded at a licensed pharmacy, not an approved pen. That is the reason it costs less, and the reason the finished preparation carries no FDA review behind it. For what differs besides the price, see compounded semaglutide vs Ozempic and Wegovy.

Safety and disclosure

Rx.com tells you its price before you start the medical questionnaire, the 47 states it serves, and the pharmacy that fills its prescriptions. We found no FDA warning letters issued to Rx.com. Because the medication is compounded, the named pharmacy is the detail that matters most: its license is the one you can look up. The FDA publishes seven warning signs for telehealth medicine sellers, and they take a minute to run against Rx.com. How we weigh oversight, disclosure and price is set out in our scoring methodology.

Who should look elsewhere

  • You want the FDA-approved pen specifically. Everything listed here is compounded.
  • You need insurance to cover the cost. Check whether Rx.com bills your plan before you start.

It fits if

  • the lowest standing monthly cost is what you are solving for
  • you want the price to stop moving as your dose climbs

Our read

Rx.com competes on price without an obvious sacrifice elsewhere: $175/month for compounded semaglutide, no FDA warning letters, and wide state coverage.

The Bottom Line

Rx.com scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on follow-up care. It charges from $99 a month, paid up front; its compounded semaglutide, at $175, is 12% below the $199 median among the sellers we compare.

Score: 8.2/10Best for: flat any-dose compounded GLP-1 pricing with the dispensing pharmacy named up frontFrom: $99/mo

Before you pay Rx.com

Starting at $99 a month. Check today's price, then start the intake.

Visit Rx.com →

Where Rx.com is the wrong choice

No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.

  • If you need the FDA-approved pen rather than a compounded vial, consider WellMedRx.
  • If the standing monthly cost is what decides it, consider Collective (from $59/mo + membership).
  • If you want a human checking in, not just a prescription, consider Eden.

If none of these fits, our guide to alternatives to Rx.com sets more sellers in the same category beside Rx.com on price, states and what the price includes.

Frequently Asked Questions

Rx.com, a prescription discount-card site, also runs its own online weight-loss program selling compounded semaglutide and tirzepatide through the MD Integrations provider network. It names its dispensing pharmacy and charges one flat price at every dose, with the provider visit, supplies and shipping included. A month at a time costs $175 for semaglutide and $285 for tirzepatide; a 12-month plan billed in one charge brings that to $99 and $149 a month. We rate it 8.2/10 overall.
Rx.com starts at $99 a month. That number holds across doses, so titrating up does not move the bill. The pricing table above lists every tier.
Rx.com names 47 states. Check that yours is on the list before you go any further.
Rx.com lists compounded semaglutide and compounded tirzepatide.
Rx.com lists compounded GLP-1s only. A licensed compounding pharmacy prepares them: same active ingredient as the brand drug, lower cash price, and no FDA approval of the finished product. That last part is the one readers underestimate, and the review above says why.
Check whether Rx.com bills your insurance before you sign up. Compounded GLP-1s are rarely covered by insurance, so plan on paying the listed cash price.
Rx.com says the price covers medication, the clinician visit and shipping. The strip near the top of this review shows what is included and what is not.
You fill in an online intake, a licensed clinician decides whether a GLP-1 is appropriate, and if the answer is yes the medication ships to you. Rx.com runs that whole sequence on its own site.
We found no FDA warning letters issued to Rx.com. Before you buy, weigh these: Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality. None of them rules Rx.com out, but each is worth settling before you pay.
Other sellers we cover include SnagRx, Lttl, and YourEra. Which one fits depends on the medication, the monthly price you can sustain and whether it ships to your state, so compare those three facts before you switch.

How to check Rx.com yourself

Every seller that ships to your state, side by side: Arizona, California, Kentucky, Maine, Nevada, Pennsylvania, Tennessee, Vermont and every other state.

Glossary

The words sellers use, defined. Tap any term.

Sources

Cited across this Rx.com review: primary regulatory filings, and peer-reviewed studies.

Sources & methodology — as of October 2026
  1. 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
  5. 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  8. 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  9. 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  10. 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  11. 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  12. 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.

See Rx.com's current pricing

Plans start at $99 a month. Whether you qualify is a clinician's decision, made after your intake.

Visit Rx.com →