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Rylo Health Review

Semaglutide & tirzepatide GLP-1 weight-loss telehealth · Independently scored 8.3/10

Best for: coverage in all 50 states, which most sellers will not confirm

8.3
★★★★☆8.3/10

Rylo Health scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on follow-up care. Its compounded semaglutide costs $99.67 a month, paid up front, 50% below the $199 median among the sellers we compare.

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$99.67/mo

charged as a multi-month plan up front

Same price at every dose

Covered by the monthly price

Medication

In the price

Clinician visits

In the price

Shipping

In the price

Lab work

Not stated

Coaching

Not stated

See plans →

Prices checked October 2026

Compare top-rated alternatives ↓

Rylo Health sells compounded tirzepatide and semaglutide, plus NAD+, sermorelin and glutathione, at one price at every dose, billed every three months. Tirzepatide is $479 a quarter and semaglutide $299, which the site shows as $160 and $100 a month, with free two-day cold shipping. Lone Star Virtual Health PLLC physicians prescribe in all 50 states, and VialsRX in Houston fills the orders.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed
Price shown up frontFlat across dosesIncludes medication + consultAll 50 statesPharmacy namedNo FDA warning letters found

Is Rylo Health legit?

Yes. Rylo Health is a real, operating US company, and we found no FDA warning letters issued to it. We rate it 8.3/10 overall, across six areas from price to trust and safety. Legitimate is not the same as right for you, though: that part is a decision for you and a licensed clinician.

Is there a Rylo Health promo or coupon code?

We know of no promo or coupon code for Rylo Health. Its listed price is $99.67 a month. Coupon sites advertising "Rylo Health discount codes" are not a source we can vouch for, and any genuine offer shows at checkout without a code.

See how Rylo Health compares on our rankings of the best semaglutide providers and the best tirzepatide providers.

Vetted alternatives to Rylo Health

9.1/ 10
Verified partner

Collective

Best for: flat any-dose pricing, if you can absorb a $199 annual membership on top

★★★★★9.1/10

Editorial score · methodology

$59/mo+ membership
CompoundedSemaglutideTirzepatide
Get StartedRead full Collective review →
9.3/ 10
Verified partner

Embody

Best for: a flat compounded tirzepatide or semaglutide price at every dose, from a seller that names its pharmacies

★★★★★9.3/10

Editorial score · methodology

$79/mo
CompoundedSemaglutideTirzepatideGlutathioneNAD+
Get StartedRead full Embody review →
7.9/ 10
Verified partner

Luvo Health

Best for: moving between compounded and brand without changing seller

★★★★☆7.9/10

Editorial score · methodology

$179/mo
CompoundedSemaglutideTirzepatideGonadorelinNAD+LegitScript Verified
Get StartedRead full Luvo Health review →
Rylo Health logo
8.3 / 10
Our editorial rating
Visit Rylo Health →

from $99.67/mo · no insurance needed

Rylo Health at a glance

Type
GLP-1 telehealth provider
Medications
Semaglutide, Tirzepatide
Starting price
$99.67/mo
Pricing model
Flat: the price stays the same as the dose goes up
What's included
Medication · Consult · Shipping
Availability
All 50 states
FDA status
No FDA warning letters found

How Rylo Health scores

Six columns, each one computed from something Rylo Health has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where a seller keeps something back, such as its price or its pharmacy, the score reflects it. Every seller we review goes through the same six columns.

Value25%

6.0/10

$99.67/month is 50% below the $199 median for compounded semaglutide across the sellers we compare. Every listed price requires paying for several months up front, so Value is capped at 6.

Effectiveness25%

10.0/10

Dispenses semaglutide and tirzepatide, compounded only. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).

User Experience15%

8.0/10

A price is shown before the questionnaire starts.

Trust & Safety15%

9.0/10

It names the pharmacy that fills its prescriptions. It shows a price before asking for health information. It lists the states it serves.

Accessibility10%

10.0/10

Serves all 50 states.

Support10%

7.0/10

The price covers the medication, clinician visits and shipping.

6weighted dimensions
734sellers compared
Everychecked against the seller's own site
Value 25%Effectiveness 25%User Experience 15%Trust & Safety 15%Accessibility 10%Support 10%

A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →

What we checked on Rylo Health

Last checked October 2026
  • Checked the listed price across 2 dose or plan tiers
  • Checked state coverage: all 50
  • Checked what the monthly price covers, and what it leaves out
  • Recorded which pharmacies the seller names as filling its prescriptions, with the page and date
  • Checked FDA warning letters for Rylo Health

Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below.

What signing up with Rylo Health involves

What to expect on the way to a prescription: where the price appears, who fills the medication, and what the monthly price covers. It is not medical advice, and a clinician makes the prescribing decision.

  1. 1Rylo Health shows a price on its own site before asking anything about you, so you can compare it with other sellers before you start a questionnaire.
  2. 2VialsRX fills the prescriptions, and Rylo Health names it publicly, which most sellers do not.
  3. 3The monthly price includes the medication, clinician visits and shipping.
Price shown before you start
  • Lowest ongoing monthly price: tirzepatide $159.67, semaglutide $99.67. That leaves out membership fees, first-month rates and insurance copays.
  • Rylo Health serves all 50 states.
  • The medication is compounded, so it is not an FDA-approved product and has not been reviewed by the agency for safety, effectiveness or manufacturing quality.

Contacting Rylo Health

Email
Rylo Health offers email support

Cancelling Rylo Health

Taken from the terms Rylo Health publishes. Terms change, so check the current policy before you subscribe.

Cancel any time
Yes
Minimum commitment
Billed every 3 months
Refund policy
Full refund any time before the first physician consultation
Early-termination fee
None

Medications Rylo Health lists

Rylo Health lists compounded semaglutide and compounded tirzepatide. Each one has its own guide: how it works, the dosing schedule, the side effects that show up in practice, and what the trials measured.

Semaglutide(compounded)Tirzepatide(compounded)

Peptides Rylo Health offers

Rylo Health sells peptides beyond the GLP-1s. Tap one to read what the evidence says about it.

DropletGlutathioneAntioxidant infusionsDropletNAD+Energy & cellular agingSyringeSermorelinOwn growth-hormone output

Pricing

Prices re-verified

All doses, $479 billed every 3 months (paid up front)Compounded
$159.67/mo
tirzepatide

Shown on the site as $160 a month. Quarterly billing is the only plan offered.

All doses, $299 billed every 3 months (paid up front)Compounded
$99.67/mo
semaglutide

Shown on the site as $100 a month. Quarterly billing is the only plan offered.

Check the price yourself before you pay

Every figure here comes from Rylo Health's own website, as of the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.

See Rylo Health pricing →

Rylo Health compounding-pharmacy partners

Rylo Health names each pharmacy below as one that compounds or fills its prescriptions, in its own site, terms or filings. The quote under each one is the seller’s own wording.

VialsRX

“Prescriptions are filled by VialsRX, 6220 Westpark Dr, Houston, TX 77057, (713) 497-5590, [website].”

Compare every compounding pharmacy we’ve reviewed →

In its favor

  • Tirzepatide costs $159.67 a month, 41% below the $269 median for compounded tirzepatide across the sellers we compare
  • Semaglutide costs $99.67 a month, 50% below the $199 median for compounded semaglutide across the sellers we compare
  • Shows its price before the medical questionnaire, so you can compare it without handing over health information
  • The monthly price stays the same as your dose goes up
  • The monthly price includes the medication, clinician visits and shipping
  • Serves all 50 states
  • Names VialsRX as the pharmacy that fills its prescriptions, which most sellers do not
  • We found no FDA warning letters issued to Rylo Health

Against it

  • Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality

What Rylo Health charges

Rylo Health charges $99.67/month, and holds that rate across every dose. That sits at the affordable end of what we see. Flat dose pricing matters more than it sounds: on a tiered plan the bill grows with the dose, so the figure that got you to sign up is not the one you end up paying.

  • Compounded tirzepatide: $159.67/month
  • Compounded semaglutide: $99.67/month

For compounded semaglutide, the median across the sellers we compare is $199/month, so Rylo Health's $99.67 is genuinely below the middle, not just advertised that way. Some of Rylo Health's plans are paid several months up front, so read the terms you agree to at checkout before you choose a longer one. Across the compounded market the dearest tenth of sellers charges about three times what the cheapest tenth does; how much GLP-1 prices actually vary explains the spread.

Oak, at about $100/month, is the closest like-for-like alternative we review.

What Rylo Health dispenses

Rylo Health prescribes semaglutide (approved as Wegovy and Ozempic) and tirzepatide (approved as Zepbound and Mounjaro). Between them these are the two best-evidenced weight-loss molecules currently on the market. What arrives is compounded at a licensed pharmacy, not an approved pen. That is the reason it costs less, and the reason the finished preparation carries no FDA review behind it. The molecule can be the one in Ozempic and Wegovy; what differs is the formulation, the concentration and the dose ladder.

Safety and disclosure

Rylo Health tells you its price before you start the medical questionnaire, that it treats patients in all 50 states, and the pharmacy that fills its prescriptions. We found no FDA warning letters issued to Rylo Health. Because the medication is compounded, the named pharmacy is the detail that matters most: its license is the one you can look up. The FDA's warning signs for online medicine sellers are a quick check to run on any seller before you pay. How we weigh oversight, disclosure and price is set out in our scoring methodology.

Rylo Health also sells NAD+, and a 2026 systematic review found no outcomes trials of injected NAD+ for anti-aging or wellness.

Who should look elsewhere

  • You want the FDA-approved pen specifically. Everything listed here is compounded.
  • You need insurance to cover the cost. Check whether Rylo Health bills your plan before you start.

It fits if

  • the lowest standing monthly cost is what you are solving for
  • you want the price to stop moving as your dose climbs
  • you need access wherever you live

Our read

Rylo Health competes on price without an obvious sacrifice elsewhere: $99.67/month, no FDA warning letters, and wide state coverage.

The Bottom Line

Rylo Health scores highest on the clinical side (which drugs it prescribes and how it doses) and lowest on follow-up care. Its compounded semaglutide costs $99.67 a month, paid up front, 50% below the $199 median among the sellers we compare.

Score: 8.3/10Best for: coverage in all 50 states, which most sellers will not confirmFrom: $99.67/mo

Before you pay Rylo Health

Starting at $99.67 a month. Check today's price, then start the intake.

Visit Rylo Health →

Where Rylo Health is the wrong choice

No seller suits every reader, and pretending otherwise is the easiest way to sell one. On these three counts, another seller does better.

  • If you need the FDA-approved pen rather than a compounded vial, consider WellMedRx.
  • If the standing monthly cost is what decides it, consider Collective (from $59/mo + membership).
  • If you want a human checking in, not just a prescription, consider Eden.

If none of these fits, our guide to alternatives to Rylo Health sets more sellers in the same category beside Rylo Health on price, states and what the price includes.

Frequently Asked Questions

Rylo Health sells compounded tirzepatide and semaglutide, plus NAD+, sermorelin and glutathione, at one price at every dose, billed every three months. Tirzepatide is $479 a quarter and semaglutide $299, which the site shows as $160 and $100 a month, with free two-day cold shipping. Lone Star Virtual Health PLLC physicians prescribe in all 50 states, and VialsRX in Houston fills the orders. We rate it 8.3/10 overall.
Rylo Health starts at $99.67 a month. That number holds across doses, so titrating up does not move the bill. The pricing table above lists every tier.
Rylo Health says it treats patients in all 50 states.
Rylo Health lists compounded semaglutide and compounded tirzepatide.
Rylo Health lists compounded GLP-1s only. A licensed compounding pharmacy prepares them: same active ingredient as the brand drug, lower cash price, and no FDA approval of the finished product. That last part is the one readers underestimate, and the review above says why.
Check whether Rylo Health bills your insurance before you sign up. It also takes FSA and HSA cards. Compounded GLP-1s are rarely covered by insurance, so plan on paying the listed cash price.
Rylo Health says the price covers medication, the clinician visit and shipping. The strip near the top of this review shows what is included and what is not.
You fill in an online intake, a licensed clinician decides whether a GLP-1 is appropriate, and if the answer is yes the medication ships to you. Rylo Health runs that whole sequence on its own site.
We found no FDA warning letters issued to Rylo Health. Before you buy, weigh these: Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality. None of them rules Rylo Health out, but each is worth settling before you pay.
Other sellers we cover include Oak, SnagRx, and Lttl. Which one fits depends on the medication, the monthly price you can sustain and whether it ships to your state, so compare those three facts before you switch.

How to check Rylo Health yourself

Every seller that ships to your state, side by side: Alaska, Colorado, Connecticut, Hawaii, North Carolina, South Dakota, Utah, Vermont and every other state.

Glossary

The words sellers use, defined. Tap any term.

Sources

Cited across this Rylo Health review: primary regulatory filings, and peer-reviewed studies.

Sources & methodology — as of October 2026
  1. 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
  2. 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
  3. 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
  4. 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
  5. 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
  6. 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  7. 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  8. 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  9. 9.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
  10. 10.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
  11. 11.FDA — Mounjaro (tirzepatide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
  12. 12.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.

See Rylo Health's current pricing

Plans start at $99.67 a month. Whether you qualify is a clinician's decision, made after your intake.

Visit Rylo Health →