Cost Plus Drugs Review
Semaglutide GLP-1 weight-loss telehealth · Independently scored 6.5/10
Best for: coverage in all 50 states, which most of the register will not confirm
Cost Plus Drugs falls below our bar on medical oversight. Read the breakdown below before you give it money.
Covered by the monthly price
Medication
Not stated
Clinician visits
Not stated
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
No insurance needed · Vetted by our editors
Cost Plus Drugs is Mark Cuban's transparent-pricing online pharmacy. It sells branded Ozempic at the wholesale acquisition cost plus a 15% markup and a flat $5 pharmacy fee, a margin formula it discloses publicly. There is no telehealth intake; this is pharmacy fulfillment only, shipping to all 50 states. Telehealth platforms that route brand-name semaglutide through similar discount channels are a separate category.
Some of the links on this page earn us money. If you sign up with a provider after following one, that provider may pay GLP Watchdog a commission. Learn more
Vetted alternatives to Cost Plus Drugs
Editorial score · methodology
Editorial score · methodology
Editorial score · methodology
Cost Plus Drugs at a glance
- Type
- GLP-1 telehealth provider
- Medications
- Ozempic
- Starting price
- $279/mo
- Availability
- All 50 states
- FDA status
- No FDA warning letter on record
How Cost Plus Drugs scores
Six columns, each one computed from something Cost Plus Drugs has published rather than from an opinion we formed: what it charges, which molecules it will dispense, what its record shows, and what the monthly figure actually buys. Where it publishes nothing, that absence is what gets scored. Every seller in the register goes through the same six columns.
Value25%
5.0/10Every published price sits implausibly far below the register median, which usually means a promotional rate or a fee recorded as a monthly cost. Held at the midpoint pending re-verification rather than rewarded.
Effectiveness25%
9.0/10Dispenses semaglutide, including the FDA-approved product. Anchored to SURMOUNT-1 (tirzepatide, -20.9%) and STEP 1 (semaglutide, -14.9%).
User Experience15%
5.0/10Where this seller first shows a price is not recorded yet, so the signup is unscored and sits at the midpoint.
Trust & Safety15%
5.0/10does not name a dispensing pharmacy; withholds price until after the intake; publishes its state list. Our verification confidence is medium.
Accessibility10%
10.0/10Publishes coverage in 50 of 50 states.
Support10%
5.0/10States too little about what the monthly cost covers to score the bundle. Held at the midpoint rather than assumed.
A seller that will not show a price before an intake loses points on Value and carries that note in its review. Withholding the number is itself a finding. How we score →
What we checked on Cost Plus Drugs
Last checked July 2026- Re-read the price on file across 1 dose or plan tier
- Checked state coverage: all 50
- Searched our FDA enforcement register for this operator
Price, availability, and compliance here are read off the seller's own pages and off primary regulatory records, named in the sources below. Editorial confidence in this data: medium.
GLP-1 medications Cost Plus Drugs offers
Each one has its own guide: how the molecule works, the dosing schedule, the side effects that show up in practice, and what the trials actually measured.
Pricing
Prices re-verified
Check the price yourself before you pay
Every figure here was read off Cost Plus Drugs's own checkout on the date shown. Sellers move prices without announcing it, and promotional rates lapse, so confirm the standing cost on their site before committing.
In its favor
- Semaglutide at $279 a month, 79% below the $1299 median for the same drug and form across this register
- Coverage is published for all 50 states
- No FDA warning letter matched this operator when we searched our enforcement register
Against it
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
What Cost Plus Drugs charges
Cost Plus Drugs charges $279/month. That sits above the middle of the market, which puts the burden on whatever else is in the package.
- Brand-name semaglutide — $279/month
The median standing price across the GLP-1 providers we track is about $169/month, so this is a premium, and a premium has to buy something. Check what is bundled before accepting it.
Direct Meds dispenses semaglutide from $249/month, which makes it the honest comparison to run before committing here.
What Cost Plus Drugs dispenses
Cost Plus Drugs prescribes semaglutide (approved as Wegovy and Ozempic). Between them these are among the best-evidenced options in this class. These are FDA-approved brand-name products rather than compounded preparations, which is the more expensive route and the one where what is in the vial has been reviewed.
What we could verify
On the record: it treats patients in all 50 states. We searched the federal warning-letter record for this operator and came back with nothing. How we weigh oversight, disclosure and price evidence is set out in our scoring methodology.
Who should look elsewhere
- You are optimizing for the twelve-month total rather than the first bill — a flat-rate seller such as CoreAge Rx will usually win that arithmetic.
- You need to bill insurance. Like most of this market, this is cash-pay.
It fits if
- you need access regardless of where you live
Our read
Cost Plus Drugs costs more than the middle of this market. If the extras it charges for are ones you would actually use, that is a defensible trade. If not, the same molecule is available for less. MangoRx is the nearest comparison we track, and worth reading alongside this.
The Bottom Line
Cost Plus Drugs falls below our bar on medical oversight. Read the breakdown below before you give it money.
Before you pay Cost Plus Drugs
Starting at $279/month. Check today's price, then book the free consultation.
Where Cost Plus Drugs is the wrong choice
No seller in this register suits every reader, and saying otherwise would be the easiest way to sell one. On these four counts another entry does better.
Frequently Asked Questions
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Sources
Cited across this Cost Plus Drugs review: primary regulatory filings, and peer-reviewed studies.
Sources & methodology — as of August 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.PCAB — Pharmacy Compounding Accreditation Board Standards— Accreditation Commission for Health Care (ACHC) / PCAB.
- 5.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 8.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
See Cost Plus Drugs's current pricing
Plans start at $279/month. The free consultation is where you learn whether you qualify, and what it costs today.