Brand-Name Semaglutide in 2026: Ozempic & Wegovy Sellers — Ranked & Reviewed
Two FDA-approved brands carry semaglutide: Ozempic for type 2 diabetes, and Wegovy for chronic weight management. Filtering to sellers that publish a brand price and ship nationwide leaves a short list, and the cash figures on it are high. Compounded semaglutide sits on a separate board because it is a separate market, priced differently and regulated differently.
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52 semaglutide providers compared · independently scored against our six-factor methodology.
Methodology & sources
Each provider here carries a score from our published six-factor rubric[1], and the list is then cut down to the form named in the page title. FDA approves brand-name Wegovy separately, for chronic weight management[2], and the agency maintains its prescribing information[3].
Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[4]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[5].
Quick Picks: Top 5
Detailed Reviews
Gala
Verified partnerBest for: moving between compounded and brand without changing seller
A yearly subscription is the format: compounded semaglutide and compounded tirzepatide are sold that way, with a cheaper microdosing program beside them and brand-name Ozempic on the same menu. The corporate name is AI Coaching Inc., which does business as Gala GLP-1 and is incorporated in Delaware. Providers licensed in every one of the 50 states, plus shipping at no cost, are what the marketing site claims. A Wegovy pill taken orally is flagged as coming soon.
Score Breakdown
Rebody Health
Best for: semaglutide from $420.99/month
Prices are published up front: compounded semaglutide from about $199.99/mo and compounded tirzepatide from about $249.99/mo as weekly injections, with daily oral melt tablets and brand-name Wegovy and Zepbound also sold, and dose-based pricing shown before each refill. Compound Technologies Inc. operates the brand in 47 states, excluding Massachusetts, Rhode Island and Vermont. Rebody is not a pharmacy, and the licensed compounding pharmacies that prepare its prescriptions are not named on the site.
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AskRx
Best for: coverage in all 50 states, which most of the register will not confirm
The subscription buys a physician, not a drug: $99-149/mo, with medication invoiced separately. AskRx never dispenses, compounds or sells anything; it routes the script to a manufacturer pharmacy, NovoCare or LillyDirect, whichever the patient picks. Its board-certified physicians write nothing compounded, only FDA-approved brand-name GLP-1s: Zepbound (tirzepatide), plus the Wegovy pen and pill (semaglutide). LegitScript approval and HIPAA compliance are claimed across all 50 states, and the subscription may qualify for HSA/FSA.
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BiltRx
Best for: moving between compounded and brand without changing seller
Among the lowest published prices: 125 dollars per month to start for compounded semaglutide, 129 dollars for compounded tirzepatide. Brands run far higher, at 1,449 dollars for Ozempic, 1,849 dollars for Wegovy, and from 1,499 dollars for Mounjaro or Zepbound. Southend Pharmacy and Boothwyn are the 503A compounders the site names, both US-licensed. This platform covers weight loss, aesthetics, and health for women and men, and holds LegitScript verification and HIPAA compliance.
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Vaylen
Best for: bloodwork inside the $179/month rather than billed on top
Vaylen is a pure GLP-1 specialist: compounded semaglutide at $179/mo, compounded tirzepatide at $239/mo, a compounded oral GLP-1 at $259/mo, and brand-name Ozempic, Zepbound, and Wegovy. LegitScript certified, with licensed clinicians in all 50 states.
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HeliMeds
Best for: moving between compounded and brand without changing seller
LegitScript has certified HeliMeds (#368688). Its GLP-1 menu runs compounded semaglutide and tirzepatide next to brand-name Zepbound and Wegovy. Energy and sexual health treatments are sold as well.
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Navio MD
Best for: moving between compounded and brand without changing seller
NavioMD sells compounded tirzepatide at $247/mo plus brand-name Ozempic at $1,199/mo and Mounjaro at $1,249/mo. It is LegitScript verified and available in 48 states, not AL or MS. The price is the same at every dose. It also offers women's hormone optimization.
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Effecty
Best for: moving between compounded and brand without changing seller
Compounded GLP-1 injections cost $160-$205/mo at Effecty, which also carries the brand-name drugs Mounjaro, Zepbound, Wegovy and Ozempic. There are no membership fees, shipping reaches all states nationwide, and the platform is LegitScript certified.
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GOAL.MD
Best for: starting below a standard dose, with microdose tiers
GOAL.MD is a St. Louis-based telehealth platform. Compounded semaglutide starts at $179/mo, brand Ozempic and Wegovy from $294/mo, and Zepbound from $394/mo, with brand pen pricing published by dose tier and offered as a bridge to the brand drugs. Renewals are manual with no auto-billing, and a nutrition coach is included free.
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Measured
Best for: starting below a standard dose, with microdose tiers
A membership of $49/mo is charged on its own, separate from the drug. On top of it sit compounded GLP-1, semaglutide and tirzepatide, opening at $79/mo for the microdose, plus Wegovy and Zepbound under their brand names. The proposition is metabolic health rather than a prescription alone, with 1:1 nutrition support and care from board-certified providers attached.
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NovoCare Pharmacy
Best for: an oral route if you will not self-inject
NovoCare Pharmacy is Novo Nordisk's own first-party direct-to-consumer pharmacy for branded Wegovy (semaglutide), a manufacturer-owned channel. Wegovy 0.25 mg and 0.5 mg starter doses run $199/month through 6/30/2026; full-dose Wegovy is $349/month at standard self-pay, and Wegovy HD is $399/month. It ships nationwide. Telehealth platforms that route Wegovy through NovoCare are a separate thing from the manufacturer pharmacy itself.
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Rex MD
Best for: coverage in all 50 states, which most of the register will not confirm
The program is a flat monthly charge of about $199, which takes in the medical intake, consultations with a provider, the prescribed drug, syringes and overnight shipping at no cost; Zepbound vials start at around $349 per month. Rex MD belongs to LifeMD, aims at men's health, and runs its weight-management program 100 percent online, prescribing brand-name semaglutide and Zepbound (tirzepatide) vials that partner pharmacies fill. Its clinicians are US-based and licensed by state, LegitScript certifies the platform, all 50 states are served, and no insurance is billed.
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FORM
Best for: starting below a standard dose, with microdose tiers
$299/month is the opening rate on compounded semaglutide, $399/month on compounded tirzepatide, with microdose tirzepatide at lower strength going for $199/month; dissolving oral tablets exist as well. Reaching FDA-approved Zepbound or Wegovy means a membership of $95/month instead. Las Vegas is the base for FORM by GBY, which writes through the provider network at Övie Health Group and sells longevity, peptide and hair treatments too. Cancel whenever; nothing binds you long term.
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Layla
Best for: moving between compounded and brand without changing seller
Oral semaglutide is 237 dollars per month, with a 187 dollar first month, and the brand-inclusive program starts around 1,299 dollars. Layla is built around semaglutide, sold as injections and as oral dropper drops, with compounded tirzepatide and a brand program covering Wegovy, Ozempic, Zepbound and Mounjaro. Care starts with a short online quiz and a licensed-provider visit; medication ships in three to five days, with 24-7 doctor messaging. Dr. Ruth Cohen is Medical Director. Compounded meds are not FDA-approved.
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NuuVim
Best for: semaglutide at $79/month, 58% under the register median
NuuVim advertises compounded semaglutide from $79/month and tirzepatide from $133/month for new users, flat across all doses with no extra fees. The Texas-based program sells both injectable and oral forms, an uncommon oral option here, plus limited brand-name Ozempic and Zepbound. It is LegitScript-certified and HIPAA-compliant, serves all 50 states plus DC, and names two pharmacy partners.
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FitRx
Best for: coverage in all 50 states, which most of the register will not confirm
Insurance coordination at FitRx can bring brand-name GLP-1s down to $25/month, and four are on offer: Mounjaro, Zepbound, Wegovy, and Ozempic. Skip insurance and compounded semaglutide starts at $151/month. DC and all 50 states are covered, and the platform holds LegitScript certification.
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Healthicare
Best for: moving between compounded and brand without changing seller
Two names Healthicare puts in public that most of this segment keeps quiet: Beluga Health, its clinical partner, and Jungle Jim's Pharmacy of Fairfield, OH, which dispenses. Coverage on this GLP-1 telehealth platform reaches 44 states. Compounded semaglutide opens at $147.90/mo, compounded tirzepatide at $224.40/mo. One account also reaches the full brand menu, Zepbound, Mounjaro, Wegovy, and Ozempic.
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Levity
Best for: semaglutide from $1199/month
Expect between 1,199 and 1,599 dollars a month once the first-month discount falls away, the exact figure depending on which drug. That single monthly fee absorbs the prescription, the consultation, delivery, follow-up care and clinical support without limit. No compounded GLP-1 is dispensed. Levity carries only FDA-approved branded products, Mounjaro (tirzepatide), Wegovy (semaglutide) and Ozempic (semaglutide), each a weekly injectable pen. A LegitScript badge is displayed and both pharmacy and physician leaders are named. It operates in 34 states, with progress tracking.
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PreventiveMD
Best for: oral orforglipron alongside the injectables
All-in figures start at $83/mo for compounded semaglutide and $97/mo for compounded tirzepatide. Foundayo, Zepbound and Wegovy come as brands under a membership arrangement. Requests reach a US-licensed provider inside 24 hours, and once approved the drug is sent to your door with care continuing through a portal online. Peptide therapy shares the platform with the GLP-1 side, all physician-guided.
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Ark Health
Best for: moving between compounded and brand without changing seller
Ark Health lists compounded semaglutide at $169/mo, tirzepatide at $249/mo and oral semaglutide at $125/mo, flat across all doses with free expedited shipping. Brand Ozempic and Mounjaro are also sold, plus wellness adjuncts such as Sermorelin and MIC/B12, giving the national platform one of the widest menus in the directory. Its brand cash prices run far above direct manufacturer channels, which leaves the compounded tier as the value play.
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Roen Rx
Best for: compounded semaglutide at $151/month
Roen Rx sells compounded semaglutide as well as brand-name Ozempic, Wegovy, Zepbound, and Mounjaro, and it coordinates insurance. LegitScript approved. Insurance-covered brand GLP-1s run as low as $25/mo, and compounded semaglutide starts at $151/mo on a quarterly plan.
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MEDVi
Best for: knowing which pharmacy fills the vial — it names Triad Rx
Two clinical groups do the treating at MEDVi: CareGLP Affiliated P.C.s, plus clinicians from OpenLoop Health. Its weight-loss menu holds compounded GLP-1s, injections and tablets alike, the molecule being semaglutide, next to Zepbound and Wegovy under their brand names. Licensed US pharmacies fill all of it.
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altRX
Best for: semaglutide from $1149/month
Compounded plans open at $149 for semaglutide and $249 for tirzepatide. Branded medication runs $1,149-$1,579, a figure that already contains the consult and the shipping. Every one of the four FDA-approved brands is stocked, Mounjaro, Ozempic, Wegovy and Zepbound, which no other entry in our directory matches. altRX works in both modalities, holds LegitScript certification, and prints the FDA compounded-medication disclaimer.
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PrideRx
Best for: tirzepatide from $299/month
The first month of membership costs $25; after that it is $99/mo, buying doctor visits and prescription management while the pharmacy invoices the drug on its own. Only brand-name GLP-1 products are sold: Foundayo (orforglipron) at $149/mo, oral semaglutide as the Wegovy Pill at $149/mo too, and Zepbound (tirzepatide) from $299/mo, each fulfilled straight through LillyDirect and NovoCare. PrideRx presents itself as LGBTQ+-friendly and also handles sexual health, PrEP and hair loss.
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RxSpan MD
Best for: knowing which pharmacy fills the vial — it names Belmar Pharmacy
RxSpan MD prices compounded semaglutide and tirzepatide from $249/mo, as injections or oral capsules, and also carries brand-name Wegovy, Zepbound and Ozempic. It is unusually transparent for the category: it names its 503A pharmacy partners, Belmar, Strive, Epiq Scripts and Casa Pharma, and its medical group. Shipping is free and unlimited 24/7 support is included. The physician-led practice was founded by Dr. John Diaz, a board-certified plastic surgeon, and is available in all 50 states.
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Better U Care
Best for: moving between compounded and brand without changing seller
Supplies are included and the cost does not shift between doses: 397 dollars for compounded tirzepatide, 298 dollars per month for compounded semaglutide. A clinical appointment at 150 dollars unlocks the brands, where Ozempic is 1,399 dollars monthly and both Mounjaro and Wegovy reach 1,695 dollars, delivery free and care continuing throughout. Self-pay is the model, and no insurance is required. Coverage stops at 21 states.
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Calibrate Health
Best for: coaching bundled into the price rather than sold separately
The program fee is $199/month and it buys no medication; the drug is billed apart and, with insurance plus a savings card, can fall to roughly $25/month. Calibrate runs a full year as a metabolic reset, pairing a branded GLP-1 drug, Wegovy, Ozempic, Zepbound or Foundayo, with video coaching one-to-one and dietitian support. That is a heavier clinical wrap than transactional telehealth offers. Only branded drugs are used, and outcomes carry a money-back guarantee.
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Luvo Health
Best for: moving between compounded and brand without changing seller
Compounded and brand GLP-1s from LUVO HEALTH, INC., sold beside microdosing, longevity peptides, skincare, HRT and testosterone. Billing is in 4-week blocks.
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Eve
Best for: moving between compounded and brand without changing seller
Eve charges $195/mo for compounded GLP-1, with brand-name options starting at $1,399/mo, on a '$0 unless approved' payment model. Its women's-health focus is distinctive in a largely gender-neutral market. The account carries compounded semaglutide and tirzepatide, an oral sublingual form included, plus brand-name Ozempic, Wegovy and Mounjaro. It is LegitScript Certified with a publicly verifiable ID.
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Klinic
Best for: seeing what it charges before you answer any medical questions
Insurance is accepted from most major plans, Medicaid and Medicare among them; paying yourself, visits open at $99. Zepbound (tirzepatide) and Wegovy (semaglutide) are prescribed under their brand names in every one of the 50 U.S. states. Home delivery and prior authorization are coordinated by the platform's pharmacy hub. Mental health, and addiction treatment through MAT, run beside weight management. LegitScript certifies the platform, which covers several conditions.
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Cost Plus Drugs
Best for: coverage in all 50 states, which most of the register will not confirm
Cost Plus Drugs is Mark Cuban's transparent-pricing online pharmacy. It sells branded Ozempic at the wholesale acquisition cost plus a 15% markup and a flat $5 pharmacy fee, a margin formula it discloses publicly. There is no telehealth intake; this is pharmacy fulfillment only, shipping to all 50 states. Telehealth platforms that route brand-name semaglutide through similar discount channels are a separate category.
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Kin Meds
Best for: oral orforglipron alongside the injectables
Kin Meds starts compounded semaglutide at $199/mo and compounded tirzepatide at $249/mo, and carries brand-name FDA-approved options including Wegovy injection and pill, Zepbound and Foundayo from $149/mo. It is LegitScript-verified. Beyond weight loss the account also covers Sermorelin, NAD+, glutathione, TRT, hair, skin and sexual health, so members can run several protocols in one place.
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Superpower
Best for: bloodwork inside the monthly price rather than billed on top
A health membership priced at $199 per year, built around 100+ biomarker lab tests taken twice a year rather than around selling GLP-1s. Members judged clinically appropriate can add prescription treatments, compounded semaglutide or brand-name Ozempic among them, through the in-house Marketplace, billed apart from the membership fee. Three fulfillment pharmacies are named: Strive Pharmacy, Belmar Pharmacy and Progress Pharmacy.
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The Virtual NP
Best for: seeing what it charges before you answer any medical questions
Two ways to pay: 99 dollars once, as you go, or 75 dollars per month for a membership carrying prescription access. Either way the drug is billed on its own, at a cost stated upfront. No compounded GLP-1 is sold. What gets written is branded and FDA-approved, made by Eli Lilly and Novo Nordisk: Zepbound (tirzepatide), Wegovy (semaglutide). HSA/FSA funds are taken and the clinic will help with prior authorization. Sandra Jordan, MSN, APRN, FNP-C founded and runs it, booking most patients inside 24 hours, with medication sent home.
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Allara Health
Best for: coaching bundled into the price rather than sold separately
Insurance is accepted, in which case the patient owes a copay or deductible; paying cash instead costs $149/month under Complete Care, while nutrition coaching alone is $125/month. The focus at allarahealth.com is metabolic and hormonal health in women, PCOS included, across 44 states plus DC. FDA-approved branded GLP-1s, Wegovy and Zepbound among them, can be prescribed, as can oral drugs including Metformin, Contrave and Topiramate. Dietitians work beside board-certified physicians and NPs, including endocrinologists and OB-GYNs. The company reports 45,000+ women served.
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Aquivia Health
Best for: moving between compounded and brand without changing seller
Every dose of compounded semaglutide costs $149/mo and every dose of compounded tirzepatide $179/mo. Patients who want a branded drug can move up to Ozempic or Zepbound, a pairing few compounded sellers offer. Aquivia Health is clinician-led and self-pay. Open Loop Healthcare Partners delivers the care. The founders are named, headed by a Chief Medical Officer and a Chief Pharmacist whose background is in 503A.
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Aspire Health
Best for: bloodwork inside the $205/month rather than billed on top
Medication is billed on top of the membership, with compounded semaglutide beginning at $149 for a 5-week supply. The LoseIt membership itself costs $200 to enroll plus $75/month, buying ongoing support, Slimpossible app access, provider visits every 2-3 months and lab orders with interpretation. Aspire Health is a telehealth practice based in Nebraska. A named PA/NP clinical team writes the prescriptions, for compounded semaglutide and tirzepatide formulated with B6 as well as brand-name Wegovy and Zepbound.
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Hello Alpha
Best for: seeing what it charges before you answer any medical questions
Neither a cash price nor a complete state list is spelled out publicly. What Hello Alpha, once called Alpha Medical, does spell out is a wide drug menu: Wegovy, Ozempic, Rybelsus, Zepbound and Mounjaro under their brand names, the oral GLP-1 Foundayo, and further oral weight-loss drugs beyond those. Insurance is part of the model, and an online membership carries ongoing clinician care.
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Modern Age
Best for: semaglutide from $900/month
Modern Age charges $500 for an Aging Wellness Assessment, covering a blood draw, at-home tests and a one-hour board-certified clinician review, then $500 for a personalized 6-month Weight Loss Program. GLP-1 medication is not included: if uninsured, branded Ozempic or Wegovy is estimated at $900-1600/mo. The longevity-focused clinic uses FDA-approved branded semaglutide (Wegovy, Ozempic) inside a structured program, and is currently available to residents in 16 states. This is a premium, clinician-led program, not a low-cost compounded subscription.
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NowPatient
Best for: an oral route if you will not self-inject
Nothing is charged for the consultation at NowPatient; the medication is the whole bill. Because the out-of-pocket cost tracks brand list prices, an uninsured patient faces roughly $1,000-$1,350/mo. Access is to brand-name GLP-1s for weight management: Saxenda is on the menu, so is Mounjaro, and Wegovy comes as an injection and as an oral tablet. The company spans the US and UK, HQ Austin, TX.
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Push Health
Best for: semaglutide from $950/month
A 55,000+ pharmacy network sits behind Push Health, which writes brand-name GLP-1 prescriptions, Mounjaro, Zepbound, and Ozempic, and routes them through it. The platform is a large US telehealth operation and holds LegitScript certification.
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JRNYS
Best for: seeing what it charges before you answer any medical questions
What you pay for coaching sets the membership: $89 to $169 per month. On top of that, JRNYS states that a member holding commercial insurance should find the GLP-1 itself capped near $25/month once any deductible clears. Self-pay exists, priced only after a provider consult. The drugs are all branded, semaglutide as Ozempic or Wegovy, tirzepatide as Mounjaro or Zepbound, plus dulaglutide and liraglutide as Saxenda, wrapped in 1-on-1 coaching. Dr. Henry Legere is CMO. The company notes the indication for these drugs is diabetes and that weight loss is an off-label use.
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Vital Edge
Best for: moving between compounded and brand without changing seller
One flat monthly fee covers the consult, the medication and shipping, and does not rise with dose. Compounded semaglutide is $350/mo, compounded tirzepatide $450/mo, and compounded oral capsules run from $199/mo; brand-name Rybelsus, Mounjaro, Wegovy and Ozempic are stocked too, an unusually broad menu. Vital Edge practices out of Chattanooga, TN, with physician-supervised GLP-1 weight loss delivered by video nationwide and medication shipped to the door monthly.
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Form Health
Best for: coaching bundled into the price rather than sold separately
Nothing compounded appears at Form Health. Three brand-name drugs do: Mounjaro, Ozempic, and Wegovy, priced the way a pharmacy normally prices them, with a physician overseeing.
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Concierge MD LA
Best for: moving between compounded and brand without changing seller
Concierge MD LA sells semaglutide at $199/mo and tirzepatide at $299/mo, alongside brand-name Ozempic, Mounjaro, Zepbound, and Wegovy at $1,999/mo each. In-home and telemedicine services are available in LA, NY, and 25+ cities.
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Medi-Weightloss
Best for: semaglutide from $199/month
A new-patient visit at Medi-Weightloss runs about $199 and covers a medical assessment, labs and a GLP-1 eligibility review; what medication costs after that depends on the plan. The physician-supervised brand has 130-plus locations nationwide alongside telehealth, and prescribes branded Wegovy and Zepbound, compounded semaglutide and compounded tirzepatide, plus older agents such as phentermine. Programs are evidence-based and include body-composition analysis and personalized plans. Insurance is accepted at many locations, and HSA/FSA funds are welcome.
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AM Rx
Best for: compounded semaglutide at $151/month
AM Rx (getamrx.com) is a telehealth platform operated by FitRX, LLC, which also operates Zealthy and FitRx. Compounded semaglutide starts at $151/mo on a quarterly plan, and brand-name GLP-1s, Ozempic, Wegovy, Zepbound, and Mounjaro, come with insurance coordination as low as $25/mo. Consultations can be video or async. HSA/FSA accepted.
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FeelGood
Best for: seeing what it charges before you answer any medical questions
FeelGood is a telehealth weight-loss program selling compounded GLP-1 medications as weekly injections and daily dissolvable tablets, plus limited brand-name options. US-licensed providers write the prescriptions and the medication ships to your home.
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Maven Clinic
Best for: coaching bundled into the price rather than sold separately
The public site carries no prices. Maven's GLP-1 Care program puts brand-name prescriptions together with on-demand visits from specialists in metabolic and hormone health, adding nutrition and strength support, and wires it into the platform's wider hormone and virtual-clinic services. Maven runs a virtual platform for women's and family health, covering fertility, maternity, menopause and pediatrics, used by 2,300+ employers. GLP-1 Care sells two ways: a Maven Consumer self-pay option, or employer health benefits. It is LegitScript-verified.
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9amHealth
Membership costs $149/month, or nothing at all where insurance picks it up, and that covers specialist visits, labs, lifestyle support and the medications themselves. join9am.com treats cardiometabolic health broadly, with weight management handled through branded GLP-1s that carry FDA approval, Wegovy, Zepbound and Saxenda, alongside FDA-approved generics. Physicians, obesity specialists board-certified as DABOM, endocrinologists, dietitians and pharmacists make up the team, which also works employer and state-plan partnerships to help patients through insurance.
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Elevated Health
Best for: moving between compounded and brand without changing seller
Elevated Health lists compounded semaglutide at $176/mo and compounded tirzepatide at $238/mo, with $100 off the first month as a promotional offer. Oral semaglutide is also on the menu.
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Evernow
Best for: seeing what it charges before you answer any medical questions
Membership at Evernow starts around $35/month for menopause access, and medication cost depends on insurance. US-licensed clinicians prescribe branded GLP-1s including Ozempic, Wegovy, Zepbound and Mounjaro. The menopause-centered women's platform is now accepting insurance for video visits, listing Blue Cross Blue Shield, Anthem, United Healthcare and Aetna, and offers 24/7 clinician messaging on one-time or membership care. Evernow positions GLP-1 as complementary to HRT, so weight loss is one vertical alongside menopause and hormone care.
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Frequently Asked Questions
Sources & methodology — as of August 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 3.FDA — Ozempic (semaglutide) Prescribing Information via Drugs@FDA— U.S. Food & Drug Administration.
- 4.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 5.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.