Compounded Semaglutide With B12 Sellers in 2026: Ranked and Reviewed

Cyanocobalamin is vitamin B12, and no approved semaglutide contains it: the Ozempic label lists semaglutide with a phosphate salt, propylene glycol, phenol and water, and nothing else. A semaglutide vial with B12 exists only because a compounding pharmacy mixed it. Every seller below names B12 in a compounded semaglutide price row or its note. FDA has said the safety and effectiveness of combining semaglutide with other ingredients has not been established, and it has named this very pairing as one it may treat as a copy of an approved drug.

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By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

55 compounded semaglutide providers compared · independently scored against our six-factor methodology.

Price and states served both move. Read them off the seller's own site before you enroll.How our reviews work →

Methodology & sources

Each provider here carries a score from our published six-factor rubric[1], and the list is then cut down to the criteria named in the page title.

Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].

Quick Picks

Starting price per provider. Prices in USD per month; checked November 2026.
#ProviderScore
1Remedy WellVisit
2Somira HealthVisit
3Lumen MedsVisit
4RiovieVisit
5EdgeRxVisit

Semaglutide with B12: what FDA has said

From FDA's compounding statements and the Ozempic label, each read on October 30, 2026.

  • Not established

    safety and effectiveness of the combination

    FDA says it knows some compounders add cyanocobalamin, B6, L-carnitine or NAD to semaglutide, and that the safety and effectiveness of combining semaglutide with other ingredients has not been established.[4]

    Why the B12 is there →
  • Essentially a copy

    FDA's example was this exact pairing

    FDA used semaglutide plus vitamin B12 as its example of a compounded product it may treat as essentially a copy of an approved drug, when both are injected and the amounts sit close to the approved strengths, unless a prescriber documents a significant difference for the patient.[5]

  • No B12

    in the approved injection

    Section 11 of the Ozempic label lists semaglutide, disodium phosphate dihydrate, propylene glycol, phenol and water for injection. No form of vitamin B12 appears.[6]

    Compounded versus brand semaglutide →

Detailed Reviews

1

Remedy Well

Best for: people who want low posted prices on compounded or oral tirzepatide, with peptides from the same clinic

9.0

Remedy Well is an online clinic that prescribes compounded semaglutide and tirzepatide, mixed with vitamin B12 or glycine, plus tirzepatide tablets, a microdose plan and $59-a-month access memberships for Zepbound and Wegovy. It also sells sermorelin, NAD+, glutathione and GHK-Cu. Semaglutide is $149 a month and tirzepatide $169, each with a discounted first month, or tirzepatide is $399 for a 3-month bundle.

Score Breakdown

Value25%
9.2
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
9.7
Support10%
7
2

Somira Health

Best for: self-pay compounded tirzepatide under $160 a month without a membership

8.7

Somira Health LLC, a San Francisco platform, connects self-pay patients to independent providers and 503A pharmacies for compounded semaglutide or tirzepatide, with B12 or glycine. Semaglutide is $139.99 a month or $299.99 every 3 months; tirzepatide is $159.99 a month or $399.99 every 3 months. Provider review, syringes and shipping are included, and it claims all 50 states, DC and Puerto Rico. Charges become non-refundable once a prescription reaches the pharmacy.

Score Breakdown

Value25%
8.7
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7
3

Lumen Meds

Best for: coaching inside the $114.99/month rather than sold separately

8.5

Lumen Meds charges $114.99 a month for compounded semaglutide and $191.99 for compounded tirzepatide, flat across doses. That price covers the provider visit, the drug and cold-packed delivery. Its refund policy adds a three-month commitment and an early-cancellation fee equal to a full retail month ($249.99 or $349.99), though its FAQ says there is no long-term commitment. Lumen Meds LLC of New Castle, Delaware runs it on MD Integrations doctors and The Pharmacy Hub in Miami Gardens.

Score Breakdown

Value25%
9
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
8.5
4

Riovie

Best for: people who want posted prices for compounded semaglutide or tirzepatide as a shot or a sublingual tablet

8.5

Riovie is an online clinic that prescribes compounded semaglutide and tirzepatide as a weekly injection or a daily under-the-tongue tablet, alongside menopause hormone therapy and longevity treatments such as sermorelin, NAD+ and glutathione. It names its medical group and its compounding pharmacy and publishes its state list. Injectable semaglutide is $149 for one month or $345 for a 3-month plan; tirzepatide is $209 or $585.

Score Breakdown

Value25%
7.1
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
10
Support10%
7
5

EdgeRx

Best for: men who want a named pharmacy and a physician-titrated GLP-1 at one monthly price

8.4

EdgeRx Health sells men's prescription protocols by monthly subscription, including compounded semaglutide and tirzepatide made with glycine and B12 by Strive Pharmacy. Semaglutide costs $199 a month and tirzepatide $225, with physician review and shipping included. The card is charged at checkout, ahead of physician review, and refunded in full if not prescribed. HSA/FSA works through Truemed.

Score Breakdown

Value25%
6.3
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
10
Accessibility10%
9.5
Support10%
7
6

FORM

Best for: choosing among plain, B12-glycine, tablet and microdose GLP-1 formats in one place

8.4

FORM by GBY is a Las Vegas telehealth brand from GBY Beauty that sells compounded semaglutide from $159 a month and tirzepatide from $219, after a cheaper first month. It also sells a FORM3 blend with B12 and glycine, dissolving tablets and a $199 microdose tirzepatide plan. Wegovy and Zepbound need a $95 monthly membership, with the drug billed separately. Prescribing runs through Architek Health and Ovie Health Group. Cancel anytime.

Score Breakdown

Value25%
6.6
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
9.7
Support10%
7
7

PeterMD

Best for: men who want GLP-1 weight loss on the same account as TRT and other men's health care

8.4

PeterMD is a men's health telehealth that also sells compounded GLP-1s. Its GLP1 + B12 program is $149 a month, sold as a $447 package of about 10 to 12 weeks, or $139 a month for returning patients. Tirzepatide starts at $149, then $249 a month billed quarterly. All sales are final once medication arrives. TRT, peptides, sexual-health and hair-loss drugs fill out the menu.

Score Breakdown

Value25%
7.6
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
9.7
Support10%
7
8

UrWay Health

Best for: people who want an all-in price with overnight shipping and a 12-week plan to cut the monthly cost

8.4

UrWay Health is a New Jersey telehealth company that prescribes compounded semaglutide and tirzepatide, each with B12, plus NAD+, glutathione, sermorelin and erectile dysfunction injections. Prices include the consult, supplies and overnight shipping, with no membership fee. Semaglutide is $249 a month at any dose or $499 for a 12-week plan; tirzepatide is $299 a month up to 9 mg, $399 at higher doses, or $599 for 12 weeks. It does not ship GLP-1s to California.

Score Breakdown

Value25%
7.2
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8.5
Accessibility10%
9.2
Support10%
7
9

YOURx Health

Best for: an oral route if you will not self-inject

8.4

YOURx Health, operated by YOURx Health LLC of Beaumont, TX, sells compounded semaglutide and tirzepatide with B12 as weekly injections or rapid-dissolve tablets. Injections are $159 a month for semaglutide and $179 for tirzepatide; tablets are $139 and $159. Care runs through MD Integrations with a physician video visit, and it is self-pay only. Its FAQ says it serves every state but Mississippi.

Score Breakdown

Value25%
8.8
Effectiveness25%
10
User Experience15%
7.5
Trust & Safety15%
7.5
Accessibility10%
9.8
Support10%
5
10

June Health

Best for: seeing what it charges before you answer any medical questions

8.3

June Health is a new telehealth storefront run by June Health LLC, with prescriptions written by the SamaritanMD and BeyondMD medical groups. It publishes a full dose-by-dose price list: oral semaglutide from $187 a month, oral tirzepatide from $249, injectable semaglutide from $279 and a one-month tirzepatide vial from $199, with the clinician evaluation included. It serves every state except MA, RI and VT.

Score Breakdown

Value25%
7.2
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
9.5
Support10%
7
11

Idun Rx

Best for: people who want posted plan prices for compounded or microdosed GLP-1s with a wellness coach

8.2

Idun Rx is an online clinic that sells compounded semaglutide and tirzepatide, lower-dose microdose versions of both, and longevity treatments such as sermorelin, NAD+ and glutathione, with wellness coaching. Prescribing is done by the White Label MD network. Semaglutide is $199 for one month or $139 a month on a 12-month plan; tirzepatide is $289, or $219 a month on 12 months.

Score Breakdown

Value25%
7.6
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
8.5
12

Invyncible

Best for: compounded semaglutide or tirzepatide bought one vial at a time, with no subscription

8.1

Invyncible is a telemedicine network that prescribes compounded semaglutide and tirzepatide by the vial and leaves the dispensing to outside pharmacies. A semaglutide program lists at $192.50 for roughly five weeks and tirzepatide at $210 for four, with blends that add glycine and B12 from $149. Nationwide Telemedicine, LLC of St. Petersburg, Florida runs it. It does not serve 10 states.

Score Breakdown

Value25%
7.9
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
8.4
Support10%
5
13

Rift

Best for: people who want cheap compounded tirzepatide and are happy to pick a pharmacy based on their state

8.1

Rift is an online platform that connects you with independent providers for compounded semaglutide and tirzepatide, plus NAD+, sermorelin and glutathione. You pick the dispensing pharmacy yourself, and the price depends on that pharmacy and the plan length, the same at every dose. Tirzepatide starts at $179 a month through one pharmacy in 25 states; semaglutide is $199 a month, or about $133 to $140 a month on 12-week plans paid up front.

Score Breakdown

Value25%
7.9
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
7
14

Stone Health

Best for: people who want posted 4-week prices for compounded GLP-1s, including oral and microdose options

8.1

Stone Health is an online clinic that prescribes compounded semaglutide and tirzepatide, low-dose GLP-1 blends with NAD+, B12 or L-carnitine, menopause care, NAD+ and sermorelin. It names four partner pharmacies, and one price covers medication, clinician care and shipping at every dose. Plans are billed every 4 weeks: semaglutide $209, tirzepatide $249, oral semaglutide $259 and the microdose blends $179.

Score Breakdown

Value25%
5.6
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
9
Accessibility10%
10
Support10%
7
15

VitaStir

Best for: a low first-month price on compounded semaglutide, with the full dose ladder published

8.1

VitaStir is a Michigan vitamin-injection clinic that also sells compounded semaglutide and tirzepatide as monthly home kits after a physician review. The kit price rises with the dose: semaglutide runs $125 to $395 a month and tirzepatide $145 to $599. Kits are non-refundable once approved, and subscriptions bill every 25 days.

Score Breakdown

Value25%
9.5
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
6.5
Accessibility10%
5
Support10%
5.5
16

10rx

Best for: a flat three-month price for compounded semaglutide or tirzepatide that does not rise with the dose

8.0

10rx sells compounded semaglutide and tirzepatide only in three-month packages, at one price whatever the dose. Semaglutide is $299 for three months and tirzepatide $449, both paid up front, with doctor visits and next-day shipping included. 10Rx, Inc. of Texas runs it, Wasef Health physicians prescribe, and it names three compounding pharmacies. Once a package is ordered it cannot be canceled or refunded.

Score Breakdown

Value25%
6
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7
Starting from $99.67/moRead full review →
Visit 10rx →
17

FMmeds

Best for: coverage in all 50 states, which most sellers will not confirm

8.0

Vitamin B12 is co-formulated into both the compounded semaglutide and the compounded tirzepatide sold here. No membership charge applies, and the first visit is free unless the patient is approved. Dose strength does not move the price. Commit to 12 months and semaglutide falls to $95/mo, tirzepatide to $145/mo. FMmeds works out of Manhattan Beach, names Manifest Pharmacy of Greer, SC as its 503A partner, and covers all 50 states and DC.

Score Breakdown

Value25%
5.1
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
10
Accessibility10%
10
Support10%
5
18

HuHealth

Best for: people who want posted, plan-by-plan compounded GLP-1 prices or a low care fee for maker-direct brand GLP-1s

7.9

HuHealth is an online clinic that prescribes compounded semaglutide and tirzepatide, NAD+, sermorelin and enclomiphene, and runs a $59 a month care plan for people buying Wegovy or Zepbound directly from the maker. Each treatment page lets you pick the pharmacy and plan length and shows the price before the intake. Semaglutide is $179 for one month or as low as $135 a month on a 12-month plan; tirzepatide is $249, or $199 a month on a 6-month plan.

Score Breakdown

Value25%
7.8
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
5
19

Kaireon Health

Best for: people who want posted, dose-flat compounded GLP-1 prices plus BPC-157, TB-500 or sermorelin from one clinic

7.9

Kaireon Health is an online clinic that prescribes compounded semaglutide and tirzepatide, each mixed with B12 or glycine, plus sermorelin, BPC-157, TB-500, MOTS-c, NAD+, epithalon and Semax. It names its medical group and three dispensing pharmacies and posts every price before you start a visit. Semaglutide is $139 a month or $375 a quarter paid up front; tirzepatide is $175 a month or $475 a quarter, at every dose.

Score Breakdown

Value25%
8.1
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
4.5
20

ARSYNL Rx

Best for: compounded semaglutide at $219 a month from a veteran-founded clinic that also treats testosterone and hair

7.8

ARSYNL Rx is a veteran-founded telehealth shop that sells compounded semaglutide and tirzepatide, both with B12, beside testosterone, hair, sexual health and longevity care. Semaglutide is $219 a month and tirzepatide $269, billed monthly with no membership fee. A needle-free tirzepatide HypoSpray is also $269 a month. Arora Health clinicians prescribe; the pharmacy is not named.

Score Breakdown

Value25%
5
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7
21

HealthSource

Best for: an oral route if you will not self-inject

7.8

Semaglutide costs $199, billed every 4 weeks. One subscription price buys the medication itself, the supplies, unlimited provider messaging over a HIPAA-compliant platform, and a telehealth visit with a physician who is board-certified. HealthSource sells compounded semaglutide and tirzepatide in two forms, injectable and oral sublingual, dispensed by a partner pharmacy that is US-based and FDA 503A licensed. All 50 US states are served, and direct-to-door delivery takes 3-5 business days.

Score Breakdown

Value25%
5
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7
22

Rejuvenate MedSpa

Best for: Ohio patients who want a local med spa to prescribe compounded semaglutide or tirzepatide

7.8

Rejuvenate MedSpa is a nurse practitioner-owned med spa in Mount Vernon, Ohio, that also prescribes compounded semaglutide and tirzepatide with B12 by telehealth or in the office, as injections or weekly oral forms. Prices are listed per month and rise with the dose: the first month with the initial appointment is $180 for semaglutide and $190 for tirzepatide, and later injection months run $180 to $320, while oral tirzepatide reaches $490. It also sells sermorelin and NAD+ kits.

Score Breakdown

Value25%
7.9
Effectiveness25%
10
User Experience15%
7.5
Trust & Safety15%
6.5
Accessibility10%
5
Support10%
7
23

Tomorrow

Best for: compounded semaglutide or tirzepatide by injection or drops, from a seller that names its pharmacies

7.8

Tomorrow is a self-pay telehealth service from Tomorrow Health LLC that offers compounded semaglutide and tirzepatide in three forms (weekly shots, lower-dose shots and under-the-tongue drops), plus brand Wegovy and Zepbound. It names its medical group, its two pharmacies and the lead physician's NPI. Paid monthly, compounded semaglutide is $199 and tirzepatide $299; the lower 'from' prices it shows are averages of a 3-month charge.

Score Breakdown

Value25%
5
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
7.5
Accessibility10%
10
Support10%
7
24

WePeptideRx

Best for: starting below a standard dose, with microdose tiers

7.7

WePeptideRx, the trade name of PureRx Biotech INC in Boca Raton, FL, sells compounded semaglutide and tirzepatide with B12, flat-priced microdoses, and brand Wegovy and Zepbound. Compounded semaglutide starts at $189 for 30 days and tirzepatide at $199, rising with each dose step, with $40 off the first order. Vials arrive premixed, so no bacteriostatic water or sharps container is needed. It serves 48 states, not Alabama or Mississippi.

Score Breakdown

Value25%
6
Effectiveness25%
10
User Experience15%
7.5
Trust & Safety15%
7.5
Accessibility10%
9.7
Support10%
5
25

You4You

Best for: people who want to buy compounded GLP-1s a month or a package at a time, with no subscription

7.7

You4You is a women-owned telehealth company whose affiliated physician group prescribes compounded semaglutide and tirzepatide, low-dose microdosing plans, and NAD+, sermorelin and glutathione. There is no subscription: you buy a month or a multi-month package, and the price rises with the dose. Semaglutide runs about $180 to $300 a month and tirzepatide $220 to $475, with consult and shipping included; a 3-month starter package is $350 for semaglutide and $550 for tirzepatide.

Score Breakdown

Value25%
6.5
Effectiveness25%
10
User Experience15%
8
Trust & Safety15%
8
Accessibility10%
5
Support10%
7

The list above shows who sells the B12 pairing and at what price. These pages cover what FDA has said and how a compounded vial differs from the brand.

Frequently Asked Questions

Sellers often say B12 eases nausea or fatigue. The two published papers on the pairing are not trials of it, and neither compared semaglutide with B12 against semaglutide alone, so that claim is unproven. FDA says the safety and effectiveness of the combination has not been established.
Not by itself. FDA used this exact pairing as its example: a semaglutide and B12 injection close to the approved strengths may be treated as essentially a copy of an approved drug, unless a prescriber documents that the change makes a significant difference for that patient.
No. Ozempic and Wegovy contain no vitamin B12, and no B12 combination is FDA-approved. A compounded vial has not been reviewed by FDA for safety, effectiveness or quality before it reaches you.
Yes. Many sellers offer both, and the board shows only that a seller names B12 somewhere in its semaglutide pricing. Ask what strength of B12 is in your vial and whether it rises with your semaglutide dose.
The table shows each seller's price for its B12 formulation with the date we checked it. Compare it with the same seller's plain semaglutide at the dose you need, on its review.
Sources & methodology — as of November 2026
  1. 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
  2. 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
  3. 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.
  4. 4.FDA alerts health care providers, compounders and patients of dosing errors associated with compounded injectable semaglutide products— U.S. Food and Drug Administration.
  5. 5.FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize— U.S. Food and Drug Administration.
  6. 6.Ozempic (semaglutide) injection prescribing information, DailyMed SPL— Novo Nordisk, via the National Library of Medicine (DailyMed).