Compounded Semaglutide With B12 Sellers in 2026: Ranked and Reviewed
Cyanocobalamin is vitamin B12, and no approved semaglutide contains it: the Ozempic label lists semaglutide with a phosphate salt, propylene glycol, phenol and water, and nothing else. A semaglutide vial with B12 exists only because a compounding pharmacy mixed it. Every seller below names B12 in a compounded semaglutide price row or its note. FDA has said the safety and effectiveness of combining semaglutide with other ingredients has not been established, and it has named this very pairing as one it may treat as a copy of an approved drug.
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55 compounded semaglutide providers compared · independently scored against our six-factor methodology.
Methodology & sources
Each provider here carries a score from our published six-factor rubric[1], and the list is then cut down to the criteria named in the page title.
Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].
Quick Picks
Semaglutide with B12: what FDA has said
From FDA's compounding statements and the Ozempic label, each read on October 30, 2026.
Not established
safety and effectiveness of the combination
FDA says it knows some compounders add cyanocobalamin, B6, L-carnitine or NAD to semaglutide, and that the safety and effectiveness of combining semaglutide with other ingredients has not been established.[4]
Why the B12 is there →Essentially a copy
FDA's example was this exact pairing
FDA used semaglutide plus vitamin B12 as its example of a compounded product it may treat as essentially a copy of an approved drug, when both are injected and the amounts sit close to the approved strengths, unless a prescriber documents a significant difference for the patient.[5]
No B12
in the approved injection
Section 11 of the Ozempic label lists semaglutide, disodium phosphate dihydrate, propylene glycol, phenol and water for injection. No form of vitamin B12 appears.[6]
Compounded versus brand semaglutide →
Detailed Reviews
Remedy Well
Best for: people who want low posted prices on compounded or oral tirzepatide, with peptides from the same clinic
Remedy Well is an online clinic that prescribes compounded semaglutide and tirzepatide, mixed with vitamin B12 or glycine, plus tirzepatide tablets, a microdose plan and $59-a-month access memberships for Zepbound and Wegovy. It also sells sermorelin, NAD+, glutathione and GHK-Cu. Semaglutide is $149 a month and tirzepatide $169, each with a discounted first month, or tirzepatide is $399 for a 3-month bundle.
Score Breakdown
Somira Health
Best for: self-pay compounded tirzepatide under $160 a month without a membership
Somira Health LLC, a San Francisco platform, connects self-pay patients to independent providers and 503A pharmacies for compounded semaglutide or tirzepatide, with B12 or glycine. Semaglutide is $139.99 a month or $299.99 every 3 months; tirzepatide is $159.99 a month or $399.99 every 3 months. Provider review, syringes and shipping are included, and it claims all 50 states, DC and Puerto Rico. Charges become non-refundable once a prescription reaches the pharmacy.
Score Breakdown
Lumen Meds
Best for: coaching inside the $114.99/month rather than sold separately
Lumen Meds charges $114.99 a month for compounded semaglutide and $191.99 for compounded tirzepatide, flat across doses. That price covers the provider visit, the drug and cold-packed delivery. Its refund policy adds a three-month commitment and an early-cancellation fee equal to a full retail month ($249.99 or $349.99), though its FAQ says there is no long-term commitment. Lumen Meds LLC of New Castle, Delaware runs it on MD Integrations doctors and The Pharmacy Hub in Miami Gardens.
Score Breakdown
Riovie
Best for: people who want posted prices for compounded semaglutide or tirzepatide as a shot or a sublingual tablet
Riovie is an online clinic that prescribes compounded semaglutide and tirzepatide as a weekly injection or a daily under-the-tongue tablet, alongside menopause hormone therapy and longevity treatments such as sermorelin, NAD+ and glutathione. It names its medical group and its compounding pharmacy and publishes its state list. Injectable semaglutide is $149 for one month or $345 for a 3-month plan; tirzepatide is $209 or $585.
Score Breakdown
EdgeRx
Best for: men who want a named pharmacy and a physician-titrated GLP-1 at one monthly price
EdgeRx Health sells men's prescription protocols by monthly subscription, including compounded semaglutide and tirzepatide made with glycine and B12 by Strive Pharmacy. Semaglutide costs $199 a month and tirzepatide $225, with physician review and shipping included. The card is charged at checkout, ahead of physician review, and refunded in full if not prescribed. HSA/FSA works through Truemed.
Score Breakdown
FORM
Best for: choosing among plain, B12-glycine, tablet and microdose GLP-1 formats in one place
FORM by GBY is a Las Vegas telehealth brand from GBY Beauty that sells compounded semaglutide from $159 a month and tirzepatide from $219, after a cheaper first month. It also sells a FORM3 blend with B12 and glycine, dissolving tablets and a $199 microdose tirzepatide plan. Wegovy and Zepbound need a $95 monthly membership, with the drug billed separately. Prescribing runs through Architek Health and Ovie Health Group. Cancel anytime.
Score Breakdown
PeterMD
Best for: men who want GLP-1 weight loss on the same account as TRT and other men's health care
PeterMD is a men's health telehealth that also sells compounded GLP-1s. Its GLP1 + B12 program is $149 a month, sold as a $447 package of about 10 to 12 weeks, or $139 a month for returning patients. Tirzepatide starts at $149, then $249 a month billed quarterly. All sales are final once medication arrives. TRT, peptides, sexual-health and hair-loss drugs fill out the menu.
Score Breakdown
UrWay Health
Best for: people who want an all-in price with overnight shipping and a 12-week plan to cut the monthly cost
UrWay Health is a New Jersey telehealth company that prescribes compounded semaglutide and tirzepatide, each with B12, plus NAD+, glutathione, sermorelin and erectile dysfunction injections. Prices include the consult, supplies and overnight shipping, with no membership fee. Semaglutide is $249 a month at any dose or $499 for a 12-week plan; tirzepatide is $299 a month up to 9 mg, $399 at higher doses, or $599 for 12 weeks. It does not ship GLP-1s to California.
Score Breakdown
YOURx Health
Best for: an oral route if you will not self-inject
YOURx Health, operated by YOURx Health LLC of Beaumont, TX, sells compounded semaglutide and tirzepatide with B12 as weekly injections or rapid-dissolve tablets. Injections are $159 a month for semaglutide and $179 for tirzepatide; tablets are $139 and $159. Care runs through MD Integrations with a physician video visit, and it is self-pay only. Its FAQ says it serves every state but Mississippi.
Score Breakdown
June Health
Best for: seeing what it charges before you answer any medical questions
June Health is a new telehealth storefront run by June Health LLC, with prescriptions written by the SamaritanMD and BeyondMD medical groups. It publishes a full dose-by-dose price list: oral semaglutide from $187 a month, oral tirzepatide from $249, injectable semaglutide from $279 and a one-month tirzepatide vial from $199, with the clinician evaluation included. It serves every state except MA, RI and VT.
Score Breakdown
Idun Rx
Best for: people who want posted plan prices for compounded or microdosed GLP-1s with a wellness coach
Idun Rx is an online clinic that sells compounded semaglutide and tirzepatide, lower-dose microdose versions of both, and longevity treatments such as sermorelin, NAD+ and glutathione, with wellness coaching. Prescribing is done by the White Label MD network. Semaglutide is $199 for one month or $139 a month on a 12-month plan; tirzepatide is $289, or $219 a month on 12 months.
Score Breakdown
Invyncible
Best for: compounded semaglutide or tirzepatide bought one vial at a time, with no subscription
Invyncible is a telemedicine network that prescribes compounded semaglutide and tirzepatide by the vial and leaves the dispensing to outside pharmacies. A semaglutide program lists at $192.50 for roughly five weeks and tirzepatide at $210 for four, with blends that add glycine and B12 from $149. Nationwide Telemedicine, LLC of St. Petersburg, Florida runs it. It does not serve 10 states.
Score Breakdown
Rift
Best for: people who want cheap compounded tirzepatide and are happy to pick a pharmacy based on their state
Rift is an online platform that connects you with independent providers for compounded semaglutide and tirzepatide, plus NAD+, sermorelin and glutathione. You pick the dispensing pharmacy yourself, and the price depends on that pharmacy and the plan length, the same at every dose. Tirzepatide starts at $179 a month through one pharmacy in 25 states; semaglutide is $199 a month, or about $133 to $140 a month on 12-week plans paid up front.
Score Breakdown
Stone Health
Best for: people who want posted 4-week prices for compounded GLP-1s, including oral and microdose options
Stone Health is an online clinic that prescribes compounded semaglutide and tirzepatide, low-dose GLP-1 blends with NAD+, B12 or L-carnitine, menopause care, NAD+ and sermorelin. It names four partner pharmacies, and one price covers medication, clinician care and shipping at every dose. Plans are billed every 4 weeks: semaglutide $209, tirzepatide $249, oral semaglutide $259 and the microdose blends $179.
Score Breakdown
VitaStir
Best for: a low first-month price on compounded semaglutide, with the full dose ladder published
VitaStir is a Michigan vitamin-injection clinic that also sells compounded semaglutide and tirzepatide as monthly home kits after a physician review. The kit price rises with the dose: semaglutide runs $125 to $395 a month and tirzepatide $145 to $599. Kits are non-refundable once approved, and subscriptions bill every 25 days.
Score Breakdown
10rx
Best for: a flat three-month price for compounded semaglutide or tirzepatide that does not rise with the dose
10rx sells compounded semaglutide and tirzepatide only in three-month packages, at one price whatever the dose. Semaglutide is $299 for three months and tirzepatide $449, both paid up front, with doctor visits and next-day shipping included. 10Rx, Inc. of Texas runs it, Wasef Health physicians prescribe, and it names three compounding pharmacies. Once a package is ordered it cannot be canceled or refunded.
Score Breakdown
FMmeds
Best for: coverage in all 50 states, which most sellers will not confirm
Vitamin B12 is co-formulated into both the compounded semaglutide and the compounded tirzepatide sold here. No membership charge applies, and the first visit is free unless the patient is approved. Dose strength does not move the price. Commit to 12 months and semaglutide falls to $95/mo, tirzepatide to $145/mo. FMmeds works out of Manhattan Beach, names Manifest Pharmacy of Greer, SC as its 503A partner, and covers all 50 states and DC.
Score Breakdown
HuHealth
Best for: people who want posted, plan-by-plan compounded GLP-1 prices or a low care fee for maker-direct brand GLP-1s
HuHealth is an online clinic that prescribes compounded semaglutide and tirzepatide, NAD+, sermorelin and enclomiphene, and runs a $59 a month care plan for people buying Wegovy or Zepbound directly from the maker. Each treatment page lets you pick the pharmacy and plan length and shows the price before the intake. Semaglutide is $179 for one month or as low as $135 a month on a 12-month plan; tirzepatide is $249, or $199 a month on a 6-month plan.
Score Breakdown
Kaireon Health
Best for: people who want posted, dose-flat compounded GLP-1 prices plus BPC-157, TB-500 or sermorelin from one clinic
Kaireon Health is an online clinic that prescribes compounded semaglutide and tirzepatide, each mixed with B12 or glycine, plus sermorelin, BPC-157, TB-500, MOTS-c, NAD+, epithalon and Semax. It names its medical group and three dispensing pharmacies and posts every price before you start a visit. Semaglutide is $139 a month or $375 a quarter paid up front; tirzepatide is $175 a month or $475 a quarter, at every dose.
Score Breakdown
ARSYNL Rx
Best for: compounded semaglutide at $219 a month from a veteran-founded clinic that also treats testosterone and hair
ARSYNL Rx is a veteran-founded telehealth shop that sells compounded semaglutide and tirzepatide, both with B12, beside testosterone, hair, sexual health and longevity care. Semaglutide is $219 a month and tirzepatide $269, billed monthly with no membership fee. A needle-free tirzepatide HypoSpray is also $269 a month. Arora Health clinicians prescribe; the pharmacy is not named.
Score Breakdown
HealthSource
Best for: an oral route if you will not self-inject
Semaglutide costs $199, billed every 4 weeks. One subscription price buys the medication itself, the supplies, unlimited provider messaging over a HIPAA-compliant platform, and a telehealth visit with a physician who is board-certified. HealthSource sells compounded semaglutide and tirzepatide in two forms, injectable and oral sublingual, dispensed by a partner pharmacy that is US-based and FDA 503A licensed. All 50 US states are served, and direct-to-door delivery takes 3-5 business days.
Score Breakdown
Rejuvenate MedSpa
Best for: Ohio patients who want a local med spa to prescribe compounded semaglutide or tirzepatide
Rejuvenate MedSpa is a nurse practitioner-owned med spa in Mount Vernon, Ohio, that also prescribes compounded semaglutide and tirzepatide with B12 by telehealth or in the office, as injections or weekly oral forms. Prices are listed per month and rise with the dose: the first month with the initial appointment is $180 for semaglutide and $190 for tirzepatide, and later injection months run $180 to $320, while oral tirzepatide reaches $490. It also sells sermorelin and NAD+ kits.
Score Breakdown
Tomorrow
Best for: compounded semaglutide or tirzepatide by injection or drops, from a seller that names its pharmacies
Tomorrow is a self-pay telehealth service from Tomorrow Health LLC that offers compounded semaglutide and tirzepatide in three forms (weekly shots, lower-dose shots and under-the-tongue drops), plus brand Wegovy and Zepbound. It names its medical group, its two pharmacies and the lead physician's NPI. Paid monthly, compounded semaglutide is $199 and tirzepatide $299; the lower 'from' prices it shows are averages of a 3-month charge.
Score Breakdown
WePeptideRx
Best for: starting below a standard dose, with microdose tiers
WePeptideRx, the trade name of PureRx Biotech INC in Boca Raton, FL, sells compounded semaglutide and tirzepatide with B12, flat-priced microdoses, and brand Wegovy and Zepbound. Compounded semaglutide starts at $189 for 30 days and tirzepatide at $199, rising with each dose step, with $40 off the first order. Vials arrive premixed, so no bacteriostatic water or sharps container is needed. It serves 48 states, not Alabama or Mississippi.
Score Breakdown
You4You
Best for: people who want to buy compounded GLP-1s a month or a package at a time, with no subscription
You4You is a women-owned telehealth company whose affiliated physician group prescribes compounded semaglutide and tirzepatide, low-dose microdosing plans, and NAD+, sermorelin and glutathione. There is no subscription: you buy a month or a multi-month package, and the price rises with the dose. Semaglutide runs about $180 to $300 a month and tirzepatide $220 to $475, with consult and shipping included; a 3-month starter package is $350 for semaglutide and $550 for tirzepatide.
Score Breakdown
30 more sellers we track for this
Ranked below the 25 above on the same rubric. Each links to its full review with current pricing.
- JustAnswer Weight Loss
- Nova MD
- Way Better MD
- EmbraceRX
- Rixa Health
- Sipra
- Wholesome Clinic
- Youth & Soul
- EOS Health
- Glow
- NEUVÉ Health
- Persona Doctors
- StackMD
- Goldspan Health
- ShapeIn Rx
- YourHealthRx
- Immortals
- Mojoon
- Alegro Health
- Blissful Wellness Integrative Medicine
- Glam Health
- RxPepsDirect
- Actin
- Revive Meds
- Stealth Health
- Gide Health
- Harmony Wellness Clinic
- Lean Rx
- DadVantage Men's Health
- LovelyMeds
Related research
The list above shows who sells the B12 pairing and at what price. These pages cover what FDA has said and how a compounded vial differs from the brand.
Frequently Asked Questions
Sources & methodology — as of November 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.
- 4.FDA alerts health care providers, compounders and patients of dosing errors associated with compounded injectable semaglutide products— U.S. Food and Drug Administration.
- 5.FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize— U.S. Food and Drug Administration.
- 6.Ozempic (semaglutide) injection prescribing information, DailyMed SPL— Novo Nordisk, via the National Library of Medicine (DailyMed).