STEP-HFpEF

Definition

Semaglutide 2.4 mg in heart failure with preserved ejection fraction plus obesity (Kosiborod et al., NEJM 2023), with substantial gains in KCCQ clinical summary score and six-minute walk distance. The first GLP-1 trial to show heart-failure-specific symptomatic benefit rather than event reduction alone.

STEP-HFpEF trial deep-dive →

GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.

Other terms under trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

Where the evidence lives

• STEP-HFpEF trial deep-dive
• The full GLP-1 glossary (149 terms, 8 categories)
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