EXSCEL

Definition

Cardiovascular outcomes for once-weekly exenatide in 14,752 adults with type 2 diabetes (Holman et al., NEJM 2017) — and the primary outcome was NEUTRAL. Exenatide did not significantly reduce MACE, which is why “GLP-1s protect the heart” is a claim about specific molecules rather than the class.

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GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.

Other terms under trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

Where the evidence lives

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