SURMOUNT-2
Definition
Tirzepatide in adults with obesity AND type 2 diabetes (Garvey et al., Lancet 2023). Tirzepatide 15 mg gave −14.7% body weight at 72 weeks against −3.2% on placebo, with HbA1c reductions beyond most diabetes-specific GLP-1 trials. It supported extending Zepbound labeling toward the T2D-with-obesity population.
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