STEP 2

Definition

Put semaglutide 2.4 mg to work in people carrying both excess weight and type 2 diabetes (Davies et al., Lancet 2021). Body weight came down 9.6% by week 68 against 3.4% on placebo, and HbA1c dropped 1.6 points. This is the trial Wegovy's use in a diabetic population rests on.

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GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.

Other terms under trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• SUMMIT
• SCALE Maintenance

Where the evidence lives

• STEP 2 trial deep-dive
• The full GLP-1 glossary (149 terms, 8 categories)
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