KCCQ-CSS (Kansas City Cardiomyopathy Questionnaire — Clinical Summary Score)

Definition

The Kansas City Cardiomyopathy Questionnaire clinical summary score, a validated patient-reported measure of heart-failure symptoms and physical limitation. Scored 0–100, higher is better, and five points is the threshold for clinically meaningful. STEP-HFpEF reported 7.8 points on semaglutide against 2.6 on placebo — the primary endpoint behind the 2024 EMA and FDA filings in HFpEF with obesity.

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GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.

Other terms under Major trials

• STEP-1
• SURMOUNT-1
• SELECT
• FLOW
• SURMOUNT-OSA
• STEP-TEENS
• MACE (Major Adverse Cardiovascular Events)
• ATTAIN-1
• IWQOL-Lite-CT
• STEP-4 (withdrawal trial)
• SYNERGY-NASH
• LEADER (trial)
• FLOW (trial)

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