LEADER (trial)
The Phase 3 trials that won approval, and the outcome studies that came afterward on cardiovascular, kidney and sleep-apnea endpoints.
What is LEADER (trial)?
The first GLP-1 cardiovascular outcomes trial to show a MACE reduction: 9,340 adults with type 2 diabetes plus established CVD or high risk, liraglutide against placebo over a median 3.8 years (Marso 2016 NEJM, PMID 27295427).
MACE HR 0.87, P=0.01. It established the class as cardioprotective before SUSTAIN-6 confirmed it.
Related reading: LEADER: The Trial That Started the Class Story
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature.
Where LEADER (trial) comes up on this site
On GLP Watchdog, LEADER comes up in 1 research article.
Research that discusses it
Other terms under Major trials
Where the evidence lives
- The full GLP-1 glossary (150 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers