IWQOL-Lite-CT

What is IWQOL-Lite-CT?

Impact of Weight on Quality of Life, Lite Clinical Trials version: a 20-item patient-reported questionnaire validated for obesity drug trials, scored 0–100 with physical-function and psychosocial subdomains reported separately.

Around 14.6 points is the meaningful-improvement threshold. STEP-1 and SURMOUNT-1 both posted large gains, which FDA used in weighing quality-of-life claims for Wegovy and Zepbound labeling.

STEP-1 quality-of-life endpoint →

GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature.

Where IWQOL-Lite-CT comes up on this site

Other terms under Major trials

• SELECT
• FLOW
• SURMOUNT-OSA
• STEP-TEENS
• MACE (Major Adverse Cardiovascular Events)
• KCCQ-CSS (Kansas City Cardiomyopathy Questionnaire, Clinical Summary Score)
• ATTAIN-1
• STEP-4 (withdrawal trial)
• SYNERGY-NASH
• LEADER (trial)
• FLOW (trial)

Where the evidence lives

• STEP-1 quality-of-life endpoint
• The full GLP-1 glossary (149 terms, 8 categories)
• Research articles — written from primary sources
• Tools and calculators
• Compare GLP-1 telehealth providers