PlushCare vs Rylo Health
PlushCare and Rylo Health both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →
Rylo Health
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Rylo Health →If you are choosing between PlushCare and Rylo Health, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Rylo Health leads our six-part score, 8.2 to 6.4.
PlushCare vs Rylo Health price
PlushCare and Rylo Health start at the same figure, $149 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $149 a month; tirzepatide is cheaper at Rylo Health ($249 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
PlushCare lists 50 states, and Rylo Health lists 50 states.
They overlap in 50 states.
Pricing
PlushCare
Range up to $299/mo
Range up to $599/mo
Rylo Health
Standard rate $149/mo; quarterly $349. A First 20 promotional rate of $100/mo is advertised for the first 20 patients.
Standard rate $249/mo; quarterly $499. A First 20 promotional rate of $160/mo is advertised for the first 20 patients.
What each price covers
Rylo Health's price also covers the clinician visit, the medication itself and shipping, which PlushCare does not claim.
PlushCare is silent on shipping and coaching.
Rylo Health is silent on lab work and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Rylo Health
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Rylo Health scores 8.2 and PlushCare 6.4 out of 10.
Rylo Health is stronger on value (6.6 vs 3.0), user experience (8.0 vs 7.0) and support (7.0 vs 0.0).
Effectiveness, trust & safety and accessibility are within half a point.
PlushCare
6.4/10
Rylo Health
8.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PlushCare nor Rylo Health has an FDA warning letter on record with us.
Features & Coverage
| Feature | PlushCare | Rylo Health |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | ✓8 features | 4 features |
| States Available | 50 | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →About Rylo Health
Compounded semaglutide and tirzepatide plus a peptide line, prescribed through Texas prescribers. Both the medical group and the dispensing pharmacy are named.
Read our full Rylo Health review →Pros & Cons
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Rylo Health
What we like
- Semaglutide costs $149 a month, 19% below the $185 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $249 a month, close to the $250 median for compounded tirzepatide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- Serves all 50 states
- We found no FDA warning letters issued to Rylo Health
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Rylo Health wins this one, 8.2 to 6.4, above all for coverage in all 50 states, which most sellers will not confirm. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
Choose Rylo Health if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
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Get started →PlushCare vs Rylo Health: FAQ
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