GLP Watchdog

Direct Meds vs PlushCare

Direct Meds has an open FDA warning letter dated September 9, 2025. PlushCare has none. On compounded semaglutide injection, PlushCare costs $1,776 less a year at standing rates: $149 a month against $297 a month at Direct Meds.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / PlushCare

Featured pick (affiliate partner)

Direct Meds logo

Direct Meds

7.1/10

PlushCare logo

PlushCare

6.4/10

FDA warning letters
None on record
Pharmacy
None named in our record
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$149/moCompounded semaglutide injection
States
48 states and DC
All 50 states
Checked
Prices captured Record checked October 2026
Prices captured Record checked September 2026
Visit Direct Meds
Visit PlushCare

Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. PlushCare pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, PlushCare 6.4). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. PlushCare has none.

  2. 02

    Neither names the pharmacy that compounds its medication.

  3. 03

    On compounded semaglutide injection, PlushCare costs $1,776 less a year at standing rates: $149 a month against $297 a month at Direct Meds.

  4. 04

    Only Direct Meds lists a price for compounded oral semaglutide and compounded oral tirzepatide.

  5. 05

    PlushCare covers two states Direct Meds does not.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; PlushCare states you can cancel at any time.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

PlushCare

Compounded semaglutide injection

$297/mo

$3,564 a year

$149/moLower

$1,788 a year

Compounded tirzepatide injection

$399/mo

$4,788 a year

$399/mo

$4,788 a year

Compounded oral semaglutide

$249/mo

$2,988 a year

Not sold or not priced
Compounded oral tirzepatide

$299/mo

$3,588 a year

Not sold or not priced
Price includes
Medication, clinician visits, shipping
Not stated
Billed separately
Not stated
Medication, clinician visits, labs
Cancel any time
No
Yes, stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
None; membership is billed monthly or annually
Refunds
No refunds for medication already received; $35 disposal fee on returns
Appointment cost only; membership fees and prescriptions are not refunded

Read off each seller’s own pages. Direct Meds: October 17, 2026. PlushCare: July 10, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10
Featured pick (affiliate partner)
  • Sells compounded oral semaglutide and compounded oral tirzepatide, which PlushCare does not price
  • Price includes clinician visits
  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for PlushCare

6.4/10
  • No FDA warning letter on record
  • $1,776 a year less on compounded semaglutide injection
  • States you can cancel at any time
  • Names no compounding pharmacy
  • Price leaves out medication, clinician visits and labs
Visit PlushCare

Scores

Direct Meds 7.1 · PlushCare 6.4 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
3.0

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
7.0

Trust & Safety15%

4.5A
vs
B
7.5

Accessibility10%

9.7A
vs
B
10.0

Support10%

7.0A
vs
B
0.0

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs PlushCare: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. PlushCare has none. Letters are matched to a seller by company, domain and address, never by a similar name.
Neither names the pharmacy that compounds its medication.
PlushCare, by $1,776 a year at standing rates. Direct Meds: $297 a month, about $3,564 a year. PlushCare: $149 a month, about $1,788 a year.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). PlushCare states you can cancel at any time; refunds: appointment cost only; membership fees and prescriptions are not refunded.
Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. PlushCare pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, PlushCare 6.4).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register