Direct Meds vs RxSpan MD
Direct Meds and RxSpan MD both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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RxSpan MD
Best for: knowing which pharmacy fills the vial: it names Belmar Pharmacy
Visit RxSpan MD →If you are choosing between Direct Meds and RxSpan MD, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. RxSpan MD leads our six-part score, 6.7 to 6.4. One of the two has an FDA warning letter on record, covered below.
Direct Meds vs RxSpan MD price
Direct Meds and RxSpan MD start at the same figure, $249 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $249 a month; tirzepatide is cheaper at Direct Meds ($299 a month vs $329 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format, Direct Meds prices compounded injections, while RxSpan MD prices compounded injections and brand-name pens.
If you want the FDA-approved brand rather than a compounded version, RxSpan MD is the only one of the two with a brand-name price.
Where each one treats patients
Direct Meds does not publish where it ships, and RxSpan MD lists 50 states.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
RxSpan MD
Plan ladder: Monthly $249/mo, 3-mo $219/mo, 6-mo $199/mo, 12-mo $194/mo. Card labeled '(For the first month)'; plan picker shows flat recurring rates (Total if prescribed $657 on 3-mo).
Plan ladder: Monthly $249/mo, 3-mo $219/mo, 6-mo $199/mo, 12-mo $179/mo.
Plan ladder: Monthly $329/mo, 3-mo $309/mo, 6-mo $289/mo, 12-mo $269/mo (Total if prescribed $927 on 3-mo).
Plan ladder: Monthly $349/mo, 3-mo $299/mo, 6-mo $289/mo, 12-mo $269/mo (Total if prescribed $897 on 3-mo).
Monthly plan only ($1,069/mo).
Monthly plan only ($1,299/mo).
Monthly plan only ($1,349/mo).
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
RxSpan MD's price also covers coaching, which Direct Meds does not claim.
Direct Meds is silent on lab work and coaching.
RxSpan MD is silent on lab work.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
RxSpan MD
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Where each one scores higher
Overall, RxSpan MD scores 6.7 and Direct Meds 6.4 out of 10.
Direct Meds is stronger on value (3.7 vs 3.0) and user experience (8.0 vs 3.0).
RxSpan MD is stronger on trust & safety (7.5 vs 3.5), accessibility (10.0 vs 5.0) and support (8.5 vs 7.0).
Effectiveness is within half a point.
Direct Meds
6.4/10
RxSpan MD
6.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
RxSpan MD has no FDA warning letter on record with us.
Features & Coverage
| Feature | Direct Meds | RxSpan MD |
|---|---|---|
| Starting Price | $249/mo | $249/mo |
| Features | 5 features | ✓7 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About RxSpan MD
RxSpan MD prices compounded semaglutide and tirzepatide from $249/mo, as injections or oral capsules, and also carries brand-name Wegovy, Zepbound and Ozempic. It is unusually transparent for the category: it names its 503A pharmacy partners, Belmar, Strive, Epiq Scripts and Casa Pharma, and its medical group. Shipping is free and unlimited 24/7 support is included. The physician-led practice was founded by Dr. John Diaz, a board-certified plastic surgeon, and is available in all 50 states.
Read our full RxSpan MD review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
RxSpan MD
What we like
- The monthly price includes the medication, clinician visits, shipping and coaching
- Serves all 50 states
- Names 4 pharmacies that fill its prescriptions, which most sellers do not
- We found no FDA warning letters issued to RxSpan MD
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $329 a month, 32% above the $250 median for compounded tirzepatide across the sellers we compare
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
RxSpan MD wins this one, 6.7 to 6.4, above all for knowing which pharmacy fills the vial: it names Belmar Pharmacy. Direct Meds fits better if compounded semaglutide at $249/month is your priority.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose RxSpan MD if…
You want knowing which pharmacy fills the vial: it names Belmar Pharmacy and an opening price near $249 a month.
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Wellorithm
Compounded semaglutide at $247/month
From $247/mo
Get started →Willow
Seeing what it charges before you answer any medical questions
From $299/mo
Get started →Sesame Care
Oral orforglipron alongside the injectables
From $59/mo
Get started →Direct Meds vs RxSpan MD: FAQ
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Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.