Rebound weight gain

Definition

Regain after stopping. The STEP-1 withdrawal extension (Wilding 2022, Diabetes Obes Metab, PMID 35441470) found people who came off semaglutide 2.4 mg after 68 weeks put back two-thirds of the lost weight within a year, with pre-treatment metabolic risk markers returning too. This is the evidence that made the class chronic therapy rather than a course of treatment.

STEP-1 withdrawal extension on our top studies list →

GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.

Other terms under Patient experience

• Plateau
• Microdosing
• Switching GLP-1s
• GLP-1 + anesthesia (preoperative)
• Subcutaneous (subq) injection
• GLP-1 in pregnancy
• Intensive Behavioral Therapy (IBT)

Where the evidence lives

• STEP-1 withdrawal extension on our top studies list
• The full GLP-1 glossary (149 terms, 8 categories)
• Research articles — written from primary sources
• Tools and calculators
• Compare GLP-1 telehealth providers