Half-life
The practical ones: titration, half-life, washout, and what a missed dose does.
What is Half-life?
How long it takes plasma concentration to halve.
Semaglutide about 7 days, tirzepatide about 5, liraglutide about 13 hours, orforglipron 29 to 49 hours. It decides weekly against daily dosing, and it decides how long a drug lingers after you stop, which is the number that matters for washout and pregnancy planning.
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature.
Where Half-life comes up on this site
On GLP Watchdog, Half-life comes up in 8 research articles and 1 tool.
Research that discusses it
- Does Your GLP-1 Wear Off Before the Next Dose?
- How Long Do Zepbound, Wegovy and Other GLP-1s Stay in Your System?
- How Long Do Semaglutide and Tirzepatide Side Effects Last?
- Stopping Tirzepatide (Zepbound): Weight Regain, Side Effects and Cold Turkey
- Stretching Doses to Save Money
- GLP-1s, Pregnancy and Trying to Conceive: What the Labels Say
- All 8 articles are on the research page
Tools that use it
Other terms under Dosing
Where the evidence lives
- The full GLP-1 glossary (150 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers