PlushCare vs Youth & Soul
PlushCare and Youth & Soul both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →
If you are choosing between PlushCare and Youth & Soul, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Youth & Soul leads our six-part score, 7.4 to 6.4.
PlushCare vs Youth & Soul price
PlushCare and Youth & Soul start at the same figure, $149 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $149 a month; tirzepatide costs the same at both, $399 a month.
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
PlushCare lists 50 states, and Youth & Soul does not publish where it ships.
Pricing
PlushCare
Range up to $299/mo
Range up to $599/mo
Youth & Soul
Compounded semaglutide 0.25mg to 1mg titration with a B12 injection, physician consultation and shipping included.
Higher-dose semaglutide 1mg to 2.4mg with metformin 500mg and a B12 plus Lipo-C injection.
Compounded tirzepatide 2.5mg to 15mg with metformin XR, B12 plus MIC and an NAD+ nasal spray.
What each price covers
Youth & Soul's price also covers the clinician visit, the medication itself and shipping, which PlushCare does not claim.
PlushCare is silent on shipping and coaching.
Youth & Soul is silent on lab work and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Youth & Soul
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Youth & Soul scores 7.4 and PlushCare 6.4 out of 10.
PlushCare is stronger on trust & safety (7.5 vs 5.5) and accessibility (10.0 vs 5.0).
Youth & Soul is stronger on value (6.6 vs 3.0), user experience (8.0 vs 7.0) and support (7.0 vs 0.0).
Effectiveness is within half a point.
PlushCare
6.4/10
Youth & Soul
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PlushCare nor Youth & Soul has an FDA warning letter on record with us.
Features & Coverage
| Feature | PlushCare | Youth & Soul |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | ✓8 features | 4 features |
| States Available | 50 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →About Youth & Soul
Compounded GLP-1 tiers sold beside HRT, ED, nootropics and peptides, ten verticals inside one marketplace. It runs on the Bask Health platform.
Read our full Youth & Soul review →Pros & Cons
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Youth & Soul
What we like
- Semaglutide costs $149 a month, 19% below the $185 median for compounded semaglutide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- We found no FDA warning letters issued to Youth & Soul
Watch-outs
- Tirzepatide costs $399 a month, 60% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Youth & Soul wins this one, 7.4 to 6.4, above all for compounded semaglutide at $149/month. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
Choose Youth & Soul if…
You want compounded semaglutide at $149/month and an opening price near $149 a month.
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Get started →PlushCare vs Youth & Soul: FAQ
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