PlushCare vs Wisp
Wisp costs $50 less a month, and both sell semaglutide and tirzepatide.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →
If you are choosing between PlushCare and Wisp, the first difference is cost: Wisp is $50 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Wisp leads our six-part score, 6.5 to 6.4.
PlushCare vs Wisp price
Wisp is the cheaper way in: $99 a month against $149 a month at PlushCare. That is $50 less each month (34% lower), or about $600 over a year of treatment.
Drug by drug: Semaglutide is cheaper at PlushCare ($149 a month vs $225 a month); tirzepatide is cheaper at Wisp ($99 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format, PlushCare prices compounded injections, while Wisp prices compounded injections and brand-name pens.
If you want the FDA-approved brand rather than a compounded version, Wisp is the only one of the two with a brand-name price.
Where each one treats patients
PlushCare lists 50 states, and Wisp does not publish where it ships.
Pricing
PlushCare
Range up to $299/mo
Range up to $599/mo
Wisp
Monthly subscription supplement, NOT a prescription GLP-1 medication. 'subscription' in form keeps it out of the GLP-1 hero price. drug omitted intentionally.
Zepbound $99/mo (compounded sublingual semaglutide $225/mo)
What each price covers
Wisp's price also covers the medication itself and shipping, which PlushCare does not claim.
PlushCare is silent on shipping and coaching.
Wisp is silent on the clinician visit, lab work and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Wisp
Covered by the monthly price
Medication
In the price
Clinician visits
Not stated
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Wisp scores 6.5 and PlushCare 6.4 out of 10.
PlushCare is stronger on trust & safety (7.5 vs 6.5) and accessibility (10.0 vs 5.0).
Wisp is stronger on value (3.5 vs 3.0), user experience (8.0 vs 7.0) and support (4.5 vs 0.0).
Effectiveness is within half a point.
PlushCare
6.4/10
Wisp
6.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PlushCare nor Wisp has an FDA warning letter on record with us.
Features & Coverage
| Feature | PlushCare | Wisp |
|---|---|---|
| Starting Price | $149/mo | ✓$99/mo |
| Features | 8 features | 8 features |
| States Available | 50 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →About Wisp
$225/month buys a compounded sublingual semaglutide drops formulation from Wisp. Its weight care vertical also stocks three brand names: Saxenda, Zepbound, and Wegovy. A board-certified provider completes the review inside 24-72 hours. LegitScript certification is in place.
Read our full Wisp review →Pros & Cons
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Wisp
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication and shipping
- We found no FDA warning letters issued to Wisp
Watch-outs
- Semaglutide costs $225 a month, 22% above the $184 median for compounded semaglutide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide is compounded rather than FDA-approved, so it has not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Wisp wins this one, 6.5 to 6.4, above all for an oral route if you will not self-inject. It also costs $50 less each month than PlushCare. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
Choose Wisp if…
You want an oral route if you will not self-inject and an opening price near $99 a month.
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Sesame Care
Oral orforglipron alongside the injectables
From $59/mo
Get started →Collective
Flat any-dose pricing, if you can absorb a $199 annual membership on top
From $59/mo
Get started →Found
Tirzepatide at $169/month, 37% below the typical price
From $149/mo
Get started →PlushCare vs Wisp: FAQ
Close alternatives to PlushCare and Wisp
- PlushCare vs altRX
- PlushCare vs Trinity Meds
- PlushCare vs Gala
- PlushCare vs Lttl
- Wisp vs GobyMeds
- Wisp vs HeliMeds
Or see the full category ranking.
Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.