PlushCare vs Sipra
PlushCare and Sipra both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →Sipra
Best for: people ready to prepay three months or more for compounded semaglutide or tirzepatide
Visit Sipra →If you are choosing between PlushCare and Sipra, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Sipra leads our six-part score, 7.6 to 6.4.
PlushCare vs Sipra price
PlushCare and Sipra start at the same figure, $149 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $149 a month; tirzepatide is cheaper at Sipra ($199 a month on a prepaid plan vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
PlushCare lists 50 states, and Sipra does not publish where it ships.
Pricing
PlushCare
Range up to $299/mo
Range up to $599/mo
Sipra
$189 a month on the shortest plan published, billed as one $567 payment. The same table lists $169 a month on a 6-month plan ($1,014) and $149 on a 12-month plan ($1,788). No 1-month price is published.
$249 a month on the 3-month plan, one $747 payment. $219 a month on 6 months ($1,314) and $199 on 12 months ($2,388).
Low-dose semaglutide plan: $149 a month for 3 months, $129 for 6 and $119 for 12.
Low-dose tirzepatide plan: $199 a month for 3 months, $179 for 6 and $159 for 12.
Sold as SemaMelt. $249 a month for 3 months, $219 for 6 and $199 for 12.
Sold as TirzaMelt. $269 a month for 3 months, $249 for 6 and $239 for 12.
What each price covers
Sipra's price also covers the clinician visit, the medication itself and shipping, which PlushCare does not claim.
PlushCare is silent on shipping and coaching.
Sipra is silent on lab work and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Sipra
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Sipra scores 7.6 and PlushCare 6.4 out of 10.
PlushCare is stronger on trust & safety (7.5 vs 6.5) and accessibility (10.0 vs 5.0).
Sipra is stronger on value (6.7 vs 3.0), user experience (8.0 vs 7.0) and support (7.0 vs 0.0).
Effectiveness is within half a point.
PlushCare
6.4/10
Sipra
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PlushCare nor Sipra has an FDA warning letter on record with us.
Features & Coverage
| Feature | PlushCare | Sipra |
|---|---|---|
| Starting Price | $149/mo | $149/mo prepaid |
| Features | 8 features | 8 features |
| States Available | 50 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warning Letters | None | None |
About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →About Sipra
Sipra is a Wyoming-registered telehealth platform whose prescribing runs through the MD Integrations physician network. It sells compounded semaglutide and tirzepatide as B12-blended weekly injections, dissolving tablets and microdose plans. Plans start at three months, paid upfront: semaglutide injections are $189 a month ($567) and tirzepatide $249 ($747), falling to $149 and $199 on a 12-month plan. You are charged only after a physician approves.
Read our full Sipra review →Pros & Cons
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Sipra
What we like
- Semaglutide costs $149 a month, 21% below the $188 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $199 a month, 20% below the $250 median for compounded tirzepatide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- We found no FDA warning letters issued to Sipra
Watch-outs
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Sipra wins this one, 7.6 to 6.4, above all for people ready to prepay three months or more for compounded semaglutide or tirzepatide. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
Choose Sipra if…
You want people ready to prepay three months or more for compounded semaglutide or tirzepatide and an opening price near $149 a month.
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Luvo Health
Moving between compounded and brand without changing seller
From $249/mo
Get started →Strut Health
Semaglutide at $99/month, 48% below the typical price
From $99/mo
Get started →Enhance MD
Knowing which pharmacy fills the vial: it names Tru Meds Rx
From $169/mo
Get started →PlushCare vs Sipra: FAQ
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