PlushCare vs Silhouette MD
PlushCare and Silhouette MD both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →
If you are choosing between PlushCare and Silhouette MD, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. PlushCare leads our six-part score, 6.4 to 6.3.
PlushCare vs Silhouette MD price
PlushCare and Silhouette MD start at the same figure, $149 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $149 a month; tirzepatide is cheaper at Silhouette MD ($299 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
PlushCare lists 50 states, and Silhouette MD does not publish where it ships.
Pricing
PlushCare
Range up to $299/mo
Range up to $599/mo
Silhouette MD
Lowest advertised tier ('as low as').
Lowest advertised tier ('as low as').
Oral formulation; lowest advertised tier.
Oral formulation; lowest advertised tier.
What each price covers
Silhouette MD's price also covers the clinician visit and the medication itself, which PlushCare does not claim.
PlushCare is silent on shipping and coaching.
Silhouette MD is silent on shipping and lab work.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Silhouette MD
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
Not stated
Lab work
Not stated
Coaching
Charged on top
Where each one scores higher
Overall, PlushCare scores 6.4 and Silhouette MD 6.3 out of 10.
PlushCare is stronger on user experience (7.0 vs 3.0), trust & safety (7.5 vs 4.0) and accessibility (10.0 vs 5.0).
Silhouette MD is stronger on value (6.6 vs 3.0) and support (5.5 vs 0.0).
Effectiveness is within half a point.
PlushCare
6.4/10
Silhouette MD
6.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PlushCare nor Silhouette MD has an FDA warning letter on record with us.
Features & Coverage
| Feature | PlushCare | Silhouette MD |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | ✓8 features | 5 features |
| States Available | 50 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →About Silhouette MD
OpenLoop Health, the licensed clinical partner here, both writes the prescription and fulfills it. Every plan carries provider oversight plus full-service support, with no higher tier to buy. Two compounded GLP-1 molecules are stocked, semaglutide and tirzepatide, each available as a shot or taken by mouth. The positioning is concierge-style.
Read our full Silhouette MD review →Pros & Cons
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Silhouette MD
What we like
- Semaglutide costs $149 a month, 19% below the $185 median for compounded semaglutide across the sellers we compare
- The monthly price includes the medication and clinician visits
- We found no FDA warning letters issued to Silhouette MD
Watch-outs
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Not included in the monthly price: coaching
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
PlushCare wins this one, 6.4 to 6.3, above all for coverage in all 50 states, which most sellers will not confirm. Silhouette MD fits better if an oral route if you will not self-inject is your priority.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
Choose Silhouette MD if…
You want an oral route if you will not self-inject and an opening price near $149 a month.
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