Piper vs PlushCare
Piper costs $14 less a month, and both sell semaglutide and tirzepatide.
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Piper
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Piper →
PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →If you are choosing between Piper and PlushCare, the first difference is cost: Piper is $14 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Piper leads our six-part score, 7.4 to 6.4.
Piper vs PlushCare price
Piper is the cheaper way in: $135 a month against $149 a month at PlushCare. That is $14 less each month (9% lower), or about $168 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Piper ($135 a month vs $149 a month); tirzepatide is cheaper at Piper ($199 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Piper lists 50 states, and PlushCare lists 50 states.
They overlap in 50 states.
Pricing
Piper
PlushCare
Range up to $299/mo
Range up to $599/mo
What each price covers
Piper's price also covers the clinician visit, the medication itself and shipping, which PlushCare does not claim.
Piper is silent on lab work and coaching.
PlushCare is silent on shipping and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
Piper
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Where each one scores higher
Overall, Piper scores 7.4 and PlushCare 6.4 out of 10.
Piper is stronger on user experience (8.0 vs 7.0), trust & safety (8.5 vs 7.5) and support (7.0 vs 0.0).
Value, effectiveness and accessibility are within half a point.
Piper
7.4/10
PlushCare
6.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither Piper nor PlushCare has an FDA warning letter on record with us.
Features & Coverage
| Feature | Piper | PlushCare |
|---|---|---|
| Starting Price | ✓$135/mo | $149/mo |
| Features | 3 features | ✓8 features |
| States Available | 50 | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About Piper
Piper is a telehealth weight loss seller offering compounded GLP-1 medications at competitive prices.
Read our full Piper review →About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →Pros & Cons
Piper
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- Serves all 50 states
- We found no FDA warning letters issued to Piper
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Piper wins this one, 7.4 to 6.4, above all for coverage in all 50 states, which most sellers will not confirm. It also costs $14 less each month than PlushCare. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose Piper if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $135 a month.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
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Compounded semaglutide at $247/month
From $247/mo
Get started →Piper vs PlushCare: FAQ
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