Direct Meds vs Willow
Direct Meds costs $50 less a month, and both sell semaglutide and tirzepatide.
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Willow
Best for: seeing what it charges before you answer any medical questions
Visit Willow →If you are choosing between Direct Meds and Willow, the first difference is cost: Direct Meds is $50 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Willow leads our six-part score, 6.6 to 6.4. One of the two has an FDA warning letter on record, covered below.
Direct Meds vs Willow price
Direct Meds is the cheaper way in: $249 a month against $299 a month at Willow. That is $50 less each month (17% lower), or about $600 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Direct Meds ($249 a month vs $299 a month); tirzepatide is cheaper at Direct Meds ($299 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Neither Direct Meds nor Willow publishes the states it serves, so enter your state at the very start of each sign-up.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
Willow
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
Direct Meds is silent on lab work and coaching.
Willow is silent on lab work and coaching.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Willow
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Willow scores 6.6 and Direct Meds 6.4 out of 10.
Direct Meds is stronger on value (3.7 vs 3.0).
Willow is stronger on trust & safety (6.5 vs 3.5).
Effectiveness, user experience, accessibility and support are within half a point.
Direct Meds
6.4/10
Willow
6.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
Willow has no FDA warning letter on record with us.
Features & Coverage
| Feature | Direct Meds | Willow |
|---|---|---|
| Starting Price | ✓$249/mo | $299/mo |
| Features | ✓5 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About Willow
Tablets and injections are both on offer at Willow, a telehealth seller of compounded GLP-1 medications.
Read our full Willow review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Willow
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
- We found no FDA warning letters issued to Willow
Watch-outs
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Willow wins this one, 6.6 to 6.4, above all for seeing what it charges before you answer any medical questions. Direct Meds undercuts it by $50 a month, so if the monthly bill is what decides it, Direct Meds is the pick. Direct Meds fits better if compounded semaglutide at $249/month is your priority.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose Willow if…
You want seeing what it charges before you answer any medical questions and an opening price near $299 a month.
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