GLP Watchdog

Direct Meds vs TrimRx

Direct Meds has an open FDA warning letter dated September 9, 2025. TrimRx has none. On compounded semaglutide injection, Direct Meds costs $24 less a year at standing rates: $297 a month against $299 a month at TrimRx.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / TrimRx

Direct Meds logo

Direct Meds

7.1/10

TrimRx logo

TrimRx

6.4/10

FDA warning letters
None on record
Pharmacy
None named in our record
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$299/moCompounded semaglutide injection
States
48 states and DC
No state list published
Checked
Prices captured Record checked October 2026
Prices captured Record checked October 2026
Visit Direct Meds
Visit TrimRx

Both Direct Meds and TrimRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, TrimRx 6.4). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. TrimRx has none.

  2. 02

    Neither names the pharmacy that compounds its medication.

  3. 03

    On compounded semaglutide injection, Direct Meds costs $24 less a year at standing rates: $297 a month against $299 a month at TrimRx.

  4. 04

    Only Direct Meds lists a price for compounded oral semaglutide and compounded oral tirzepatide. Only TrimRx lists a price for brand-name semaglutide pen and brand-name tirzepatide pen.

  5. 05

    Direct Meds lists 48 states and DC. TrimRx publishes no state list.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; TrimRx states you can cancel at any time.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

TrimRx

Compounded semaglutide injection

$297/moLower

$3,564 a year

$299/mo

$3,588 a year

Compounded tirzepatide injection

$399/mo

$4,788 a year

$399/mo

$4,788 a year

Brand-name semaglutide pen
Not sold or not priced

$1,299/mo

$15,588 a year

Brand-name tirzepatide pen
Not sold or not priced

$1,399/mo

$16,788 a year

Compounded oral semaglutide

$249/mo

$2,988 a year

Not sold or not priced
Compounded oral tirzepatide

$299/mo

$3,588 a year

Not sold or not priced
Price includes
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Cancel any time
No
Yes, stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
None on the monthly plan; multi-month plans are prepaid
Refunds
No refunds for medication already received; $35 disposal fee on returns
Full refund if a provider finds you ineligible; other refund requests within 28 days of payment

Read off each seller’s own pages. Direct Meds: October 17, 2026. TrimRx: October 25, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10
  • $24 a year less on compounded semaglutide injection
  • Sells compounded oral semaglutide and compounded oral tirzepatide, which TrimRx does not price
  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for TrimRx

6.4/10
  • No FDA warning letter on record
  • Sells brand-name semaglutide pen and brand-name tirzepatide pen, which Direct Meds does not price
  • States you can cancel at any time
  • Names no compounding pharmacy
  • Publishes no state list
Visit TrimRx

Scores

Direct Meds 7.1 · TrimRx 6.4 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
2.2

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
8.0

Trust & Safety15%

4.5A
vs
B
6.5

Accessibility10%

9.7A
vs
B
5.0

Support10%

7.0A
vs
B
7.0

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs TrimRx: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. TrimRx has none. Letters are matched to a seller by company, domain and address, never by a similar name.
Neither names the pharmacy that compounds its medication.
Direct Meds, by $24 a year at standing rates. Direct Meds: $297 a month, about $3,564 a year. TrimRx: $299 a month, about $3,588 a year.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). TrimRx states you can cancel at any time; refunds: full refund if a provider finds you ineligible; other refund requests within 28 days of payment.
Both Direct Meds and TrimRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, TrimRx 6.4).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register

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