Direct Meds vs TMates
Direct Meds and TMates both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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TMates
Best for: coaching inside the $249/month rather than sold separately
Visit TMates →If you are choosing between Direct Meds and TMates, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. TMates leads our six-part score, 7.6 to 6.4. One of the two has an FDA warning letter on record, covered below.
Direct Meds vs TMates price
Direct Meds and TMates start at the same figure, $249 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $249 a month; tirzepatide is cheaper at TMates ($297 a month vs $299 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Direct Meds does not publish where it ships, and TMates lists 50 states.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
TMates
1 month $249; 3 months $217/mo ($650, save 13%); 6 months $175/mo ($1,050, save 30%); 12 months $158/mo ($1,900, save 37%). Injectable or oral at the same price. Includes medication and ongoing support, free shipping, cancel anytime.
1 month $297; 3 months $267/mo ($800, save 10%); 6 months $217/mo ($1,299, save 27%); 12 months $167/mo ($1,999, save 44%). Injectable or oral at the same price.
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
TMates' price also covers coaching, which Direct Meds does not claim.
Direct Meds is silent on lab work and coaching.
TMates is silent on lab work.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
TMates
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Where each one scores higher
Overall, TMates scores 7.6 and Direct Meds 6.4 out of 10.
TMates is stronger on trust & safety (7.5 vs 3.5), accessibility (10.0 vs 5.0) and support (8.5 vs 7.0).
Value, effectiveness and user experience are within half a point.
Direct Meds
6.4/10
TMates
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
TMates has no FDA warning letter on record with us.
Features & Coverage
| Feature | Direct Meds | TMates |
|---|---|---|
| Starting Price | $249/mo | $249/mo |
| Features | ✓5 features | 4 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About TMates
TMates is a Miami-based telehealth platform selling compounded semaglutide at $249/mo and compounded tirzepatide at $297/mo across all 50 states plus Puerto Rico. The model is messaging-first, with independent licensed prescribers and third-party compounding pharmacies.
Read our full TMates review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 35% above the $185 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
TMates
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits, shipping and coaching
- Serves all 50 states
- We found no FDA warning letters issued to TMates
Watch-outs
- Semaglutide costs $249 a month, 35% above the $185 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $297 a month, 19% above the $250 median for compounded tirzepatide across the sellers we compare
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Direct Meds is where we would start, above all for compounded semaglutide at $249/month. TMates fits better if coaching inside the $249/month rather than sold separately is your priority.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose TMates if…
You want coaching inside the $249/month rather than sold separately and an opening price near $249 a month.
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