GLP Watchdog

Direct Meds vs ShedRx

Direct Meds has an open FDA warning letter dated September 9, 2025. ShedRx has none. On compounded tirzepatide injection, ShedRx costs $1,200 less a year at standing rates: $299 a month against $399 a month at Direct Meds. It is one of three products the two sell at comparable terms.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / ShedRx

Direct Meds logo

Direct Meds

7.1/10

ShedRx logo

ShedRx

7.9/10

FDA warning letters
None on record
Pharmacy
None named in our record
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$199/moCompounded semaglutide injection
States
48 states and DC
All 50 states
Checked
Prices captured Record checked October 2026
Prices captured Record checked November 2026
Visit Direct Meds
Visit ShedRx

Both Direct Meds and ShedRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, ShedRx 7.9). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. ShedRx has none.

  2. 02

    Neither names the pharmacy that compounds its medication.

  3. 03

    On compounded tirzepatide injection, ShedRx costs $1,200 less a year at standing rates: $299 a month against $399 a month at Direct Meds. It is one of three products the two sell at comparable terms.

  4. 04

    Only Direct Meds lists a price for compounded oral tirzepatide. Only ShedRx lists a price for brand-name semaglutide pen, brand-name tirzepatide pen and brand-name semaglutide pill.

  5. 05

    ShedRx covers two states Direct Meds does not.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; ShedRx states you can cancel at any time.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

ShedRx

Compounded semaglutide injection

$297/mo

$3,564 a year

$199/moLower

$2,388 a year

Compounded tirzepatide injection

$399/mo

$4,788 a year

$299/moLower

$3,588 a year

Compounded oral semaglutide

$249/mo

$2,988 a year

$229/moLower

$2,748 a year

Brand-name semaglutide pen
Not sold or not priced

$199/mo

medication only, membership extra; not compared

Brand-name tirzepatide pen
Not sold or not priced

$299/mo

medication only, membership extra; not compared

Compounded oral tirzepatide

$299/mo

$3,588 a year

Not sold or not priced
Brand-name semaglutide pill
Not sold or not priced

$149/mo

medication only, membership extra; not compared

Foundayo (orforglipron) pill
Not sold or not priced

$149/mo

medication only, membership extra; not compared

Price includes
Medication, clinician visits, shipping
Medication, clinician visits, shipping, coaching
Cancel any time
No
Yes, stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
No minimum commitment: the terms remove minimum commitments and early-termination charges; 6- and 12-month plans are paid up front or in installments
Refunds
No refunds for medication already received; $35 disposal fee on returns
Non-refundable once charged; multi-month refunds cover unshipped cycles only, after repricing used months at the monthly rate; 120-day guarantee for first-time users
Early-exit fee
Not stated
None stated

Read off each seller’s own pages. Direct Meds: October 17, 2026. ShedRx: November 6, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10
  • Sells compounded oral tirzepatide, which ShedRx does not price
  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for ShedRx

7.9/10
  • No FDA warning letter on record
  • $1,176 a year less on compounded semaglutide injection
  • $1,200 a year less on compounded tirzepatide injection
  • Sells brand-name semaglutide pen and brand-name tirzepatide pen, which Direct Meds does not price
  • Names no compounding pharmacy
Visit ShedRx

Scores

Direct Meds 7.1 · ShedRx 7.9 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
5.0

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
8.0

Trust & Safety15%

4.5A
vs
B
7.5

Accessibility10%

9.7A
vs
B
10.0

Support10%

7.0A
vs
B
8.5

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs ShedRx: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. ShedRx has none. Letters are matched to a seller by company, domain and address, never by a similar name.
Neither names the pharmacy that compounds its medication.
ShedRx, by $1,176 a year at standing rates. Direct Meds: $297 a month, about $3,564 a year. ShedRx: $199 a month, about $2,388 a year.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). ShedRx states you can cancel at any time; refunds: non-refundable once charged; multi-month refunds cover unshipped cycles only, after repricing used months at the monthly rate; 120-day guarantee for first-time users.
Both Direct Meds and ShedRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, ShedRx 7.9).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register

Brand names on this page are registered marks. Novo Nordisk holds Wegovy®, Ozempic® and Rybelsus®; Eli Lilly holds Zepbound®, Mounjaro® and Foundayo®. Neither company has any tie to GLP Watchdog. Trademarks