Cost Plus Drugs vs MangoRx
Cost Plus Drugs costs $20 less a month, and both sell semaglutide.
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Cost Plus Drugs
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Cost Plus Drugs →
If you are choosing between Cost Plus Drugs and MangoRx, the first difference is cost: Cost Plus Drugs is $20 a month cheaper at the entry price. Both prescribe semaglutide, so moving from one to the other would not change your drug. Cost Plus Drugs leads our six-part score, 7.8 to 4.6.
Cost Plus Drugs vs MangoRx price
Cost Plus Drugs is the cheaper way in: $279 a month against $299 a month at MangoRx. That is $20 less each month (7% lower), or about $240 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Cost Plus Drugs ($279 a month vs $299 a month).
Medications and formats
Both sell semaglutide.
On format, Cost Plus Drugs prices brand-name pens, while MangoRx prices an oral option.
If you want the FDA-approved brand rather than a compounded version, Cost Plus Drugs is the only one of the two with a brand-name price.
Where each one treats patients
Cost Plus Drugs lists 50 states, and MangoRx does not publish where it ships.
Pricing
Cost Plus Drugs
MangoRx
Slim = oral semaglutide + Vitamin B6, 30-day supply of daily mint-flavored ODTs. Subscribe & Save: 10% off initial and all auto-refill orders + free UPS Ground shipping; auto-refills every 25 days. Provider visit and shipping advertised as free on all orders. No injectable option, no tirzepatide product page. Insurance not accepted.
What each price covers
MangoRx's price also covers the clinician visit and the medication itself, which Cost Plus Drugs does not claim.
Cost Plus Drugs does not say what its price includes.
MangoRx is silent on shipping, lab work and coaching.
That matters most for the drug: unless Cost Plus Drugs confirms otherwise, budget for medication on top of its listed price.
Cost Plus Drugs
Inclusions not disclosed.
MangoRx
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Cost Plus Drugs scores 7.8 and MangoRx 4.6 out of 10.
Cost Plus Drugs is stronger on value (10.0 vs 2.1), effectiveness (9.0 vs 8.5), user experience (5.0 vs 3.0), trust & safety (5.0 vs 3.0) and accessibility (10.0 vs 5.0).
MangoRx is stronger on support (5.5 vs 5.0).
Cost Plus Drugs
7.8/10
MangoRx
4.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither Cost Plus Drugs nor MangoRx has an FDA warning letter on record with us.
Features & Coverage
| Feature | Cost Plus Drugs | MangoRx |
|---|---|---|
| Starting Price | ✓$279/mo | $299/mo |
| Features | ✓5 features | 3 features |
| States Available | 50 | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About Cost Plus Drugs
Cost Plus Drugs is Mark Cuban's transparent-pricing online pharmacy. It sells branded Ozempic at the wholesale acquisition cost plus a 15% markup and a flat $5 pharmacy fee, a margin formula it discloses publicly. There is no telehealth intake; this is pharmacy fulfillment only, shipping to all 50 states. Telehealth platforms that route brand-name semaglutide through similar discount channels are a separate category.
Read our full Cost Plus Drugs review →About MangoRx
Verification is still outstanding on the GLP-1 side of MangoRx (Mangoceuticals). Pricing, states, pharmacy partners, and clinical workflow have not cleared our YMYL check, so this stays a stub entry. The men's health platform sells compounded GLP-1 weight management, and beside it hair loss programs, ED treatment, and testosterone replacement therapy.
Read our full MangoRx review →Pros & Cons
Cost Plus Drugs
What we like
- Semaglutide costs $279 a month, 72% below the $997 median for brand-name semaglutide across the sellers we compare
- Serves all 50 states
- We found no FDA warning letters issued to Cost Plus Drugs
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
MangoRx
What we like
- The monthly price includes the medication and clinician visits
- We found no FDA warning letters issued to MangoRx
Watch-outs
- Semaglutide costs $299 a month, 50% above the $199 median for oral semaglutide across the sellers we compare
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide is compounded rather than FDA-approved, so it has not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
MangoRx is where we would start, above all for an oral route if you will not self-inject. Cost Plus Drugs undercuts it by $20 a month, so if the monthly bill is what decides it, Cost Plus Drugs is the pick. Cost Plus Drugs fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose Cost Plus Drugs if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $279 a month.
Choose MangoRx if…
You want an oral route if you will not self-inject and an opening price near $299 a month.
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Get started →Cost Plus Drugs vs MangoRx: FAQ
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Or see the full category ranking.
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