Cost Plus Drugs vs Medi-Weightloss
Medi-Weightloss costs $80 less a month, and both sell semaglutide.
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Cost Plus Drugs
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Cost Plus Drugs →
If you are choosing between Cost Plus Drugs and Medi-Weightloss, the first difference is cost: Medi-Weightloss is $80 a month cheaper at the entry price. Both prescribe semaglutide, so moving from one to the other would not change your drug. Cost Plus Drugs leads our six-part score, 7.8 to 5.5.
Cost Plus Drugs vs Medi-Weightloss price
Medi-Weightloss is the cheaper way in: $199 a month against $279 a month at Cost Plus Drugs. That is $80 less each month (29% lower), or about $960 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Medi-Weightloss ($199 a month vs $279 a month).
Medications and formats
Both sell semaglutide.
On format they match: each offers brand-name pens.
Where each one treats patients
Cost Plus Drugs lists 50 states, and Medi-Weightloss does not publish where it ships.
Pricing
Cost Plus Drugs
Medi-Weightloss
What each price covers
Neither Cost Plus Drugs nor Medi-Weightloss spells out what its price covers, so ask whether the visit, the drug and shipping are all in the monthly figure.
Where each one scores higher
Overall, Cost Plus Drugs scores 7.8 and Medi-Weightloss 5.5 out of 10.
Cost Plus Drugs is stronger on value (10.0 vs 5.0), user experience (5.0 vs 2.5), trust & safety (5.0 vs 4.0) and accessibility (10.0 vs 5.0).
Effectiveness and support are within half a point.
Cost Plus Drugs
7.8/10
Medi-Weightloss
5.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither Cost Plus Drugs nor Medi-Weightloss has an FDA warning letter on record with us.
Features & Coverage
| Feature | Cost Plus Drugs | Medi-Weightloss |
|---|---|---|
| Starting Price | $279/mo | ✓$199/mo |
| Features | 5 features | ✓8 features |
| States Available | 50 | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warning Letters | None | None |
About Cost Plus Drugs
Cost Plus Drugs is Mark Cuban's transparent-pricing online pharmacy. It sells branded Ozempic at the wholesale acquisition cost plus a 15% markup and a flat $5 pharmacy fee, a margin formula it discloses publicly. There is no telehealth intake; this is pharmacy fulfillment only, shipping to all 50 states. Telehealth platforms that route brand-name semaglutide through similar discount channels are a separate category.
Read our full Cost Plus Drugs review →About Medi-Weightloss
A new-patient visit at Medi-Weightloss runs about $199 and covers a medical assessment, labs and a GLP-1 eligibility review; what medication costs after that depends on the plan. The physician-supervised brand has 130-plus locations nationwide alongside telehealth, and prescribes branded Wegovy and Zepbound, compounded semaglutide and compounded tirzepatide, plus older agents such as phentermine. Programs are evidence-based and include body-composition analysis and personalized plans. Insurance is accepted at many locations, and HSA/FSA funds are welcome.
Read our full Medi-Weightloss review →Pros & Cons
Cost Plus Drugs
What we like
- Semaglutide costs $279 a month, 72% below the $990 median for brand-name semaglutide across the sellers we compare
- Serves all 50 states
- We found no FDA warning letters issued to Cost Plus Drugs
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
Medi-Weightloss
What we like
- Semaglutide costs $199 a month, 80% below the $990 median for brand-name semaglutide across the sellers we compare
- The monthly price stays the same as your dose goes up
- We found no FDA warning letters issued to Medi-Weightloss
- Baseline bloodwork is required before a prescription
Watch-outs
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
Our Verdict
Cost Plus Drugs wins this one, 7.8 to 5.5, above all for coverage in all 50 states, which most sellers will not confirm. Medi-Weightloss undercuts it by $80 a month, so if the monthly bill is what decides it, Medi-Weightloss is the pick. Medi-Weightloss fits better if semaglutide from $199/month is your priority.
Choose Cost Plus Drugs if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $279 a month.
Choose Medi-Weightloss if…
You want semaglutide from $199/month and an opening price near $199 a month.
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Wellorithm
Compounded semaglutide at $247/month
From $247/mo
Get started →Willow
Seeing what it charges before you answer any medical questions
From $299/mo
Get started →Sesame Care
Oral orforglipron alongside the injectables
From $59/mo
Get started →Cost Plus Drugs vs Medi-Weightloss: FAQ
Close alternatives to Cost Plus Drugs and Medi-Weightloss
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- Cost Plus Drugs vs Superpower
- Medi-Weightloss vs Superpower
- Medi-Weightloss vs Eclipse Medical Wellness
- Medi-Weightloss vs NovoCare Pharmacy
Or see the full category ranking.
Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.