Cost Plus Drugs vs Superpower
Superpower costs $80 less a month, and both sell semaglutide.
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Cost Plus Drugs
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Cost Plus Drugs →
Superpower
Best for: bloodwork inside the monthly price rather than billed on top
Visit Superpower →If you are choosing between Cost Plus Drugs and Superpower, the first difference is cost: Superpower is $80 a month cheaper at the entry price. Both prescribe semaglutide, so moving from one to the other would not change your drug. Cost Plus Drugs leads our six-part score, 7.8 to 6.0.
Cost Plus Drugs vs Superpower price
Superpower is the cheaper way in: $199 a month on a prepaid plan against $279 a month at Cost Plus Drugs. That is $80 less each month (29% lower), or about $960 over a year of treatment.
Superpower's figure is a monthly average of a plan billed for several months at once, so the first charge is larger than the number shown.
Drug by drug: Semaglutide is cheaper at Superpower ($199 a month on a prepaid plan vs $279 a month).
Medications and formats
Both sell semaglutide.
On format, Cost Plus Drugs prices brand-name pens, while Superpower prices compounded injections and brand-name pens.
Where each one treats patients
Cost Plus Drugs lists 50 states, and Superpower lists 42 states.
They overlap in 41 states. Cost Plus Drugs alone covers 9 states, including Alaska, Arkansas, Hawaii and Louisiana. Superpower alone covers District of Columbia.
Pricing
Cost Plus Drugs
Superpower
Marketing 'from' price on superpower.com/semaglutide; the standalone Marketplace product listing for the same compounded semaglutide shows $229/mo. Separate from the $199/year membership fee.
Brand Ozempic 'from' price shown alongside the compounded option on the same page; same bimonthly upfront-billing cadence applies.
What each price covers
Superpower's price also covers the medication itself and lab work, which Cost Plus Drugs does not claim.
Cost Plus Drugs does not say what its price includes.
Superpower is silent on the clinician visit, shipping and coaching.
That matters most for the drug: unless Cost Plus Drugs confirms otherwise, budget for medication on top of its listed price.
Cost Plus Drugs
Inclusions not disclosed.
Superpower
Covered by the monthly price
Medication
In the price
Clinician visits
Not stated
Shipping
Not stated
Lab work
In the price
Coaching
Not stated
Where each one scores higher
Overall, Cost Plus Drugs scores 7.8 and Superpower 6.0 out of 10.
Cost Plus Drugs is stronger on value (10.0 vs 0.7), accessibility (10.0 vs 8.7) and support (5.0 vs 4.5).
Superpower is stronger on user experience (7.5 vs 5.0) and trust & safety (7.5 vs 5.0).
Effectiveness is within half a point.
Cost Plus Drugs
7.8/10
Superpower
6.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither Cost Plus Drugs nor Superpower has an FDA warning letter on record with us.
Features & Coverage
| Feature | Cost Plus Drugs | Superpower |
|---|---|---|
| Starting Price | $279/mo | ✓$199/mo prepaid |
| Features | 5 features | ✓7 features |
| States Available | ✓50 | 42 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warning Letters | None | None |
About Cost Plus Drugs
Cost Plus Drugs is Mark Cuban's transparent-pricing online pharmacy. It sells branded Ozempic at the wholesale acquisition cost plus a 15% markup and a flat $5 pharmacy fee, a margin formula it discloses publicly. There is no telehealth intake; this is pharmacy fulfillment only, shipping to all 50 states. Telehealth platforms that route brand-name semaglutide through similar discount channels are a separate category.
Read our full Cost Plus Drugs review →About Superpower
A health membership priced at $199 per year, built around 100+ biomarker lab tests taken twice a year rather than around selling GLP-1s. Members judged clinically appropriate can add prescription treatments, compounded semaglutide or brand-name Ozempic among them, through the in-house Marketplace, billed apart from the membership fee. Three fulfillment pharmacies are named: Strive Pharmacy, Belmar Pharmacy and Progress Pharmacy.
Read our full Superpower review →Pros & Cons
Cost Plus Drugs
What we like
- Semaglutide costs $279 a month, 72% below the $990 median for brand-name semaglutide across the sellers we compare
- Serves all 50 states
- We found no FDA warning letters issued to Cost Plus Drugs
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
Superpower
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication and lab work
- Serves 42 states
- We found no FDA warning letters issued to Superpower
- Baseline bloodwork is required before a prescription
Watch-outs
- Semaglutide costs $1799 a month, 82% above the $990 median for brand-name semaglutide across the sellers we compare
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide is compounded rather than FDA-approved, so it has not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Cost Plus Drugs wins this one, 7.8 to 6.0, above all for coverage in all 50 states, which most sellers will not confirm. Superpower undercuts it by $80 a month, so if the monthly bill is what decides it, Superpower is the pick. Superpower fits better if bloodwork inside the monthly price rather than billed on top is your priority.
Choose Cost Plus Drugs if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $279 a month.
Choose Superpower if…
You want bloodwork inside the monthly price rather than billed on top and an opening price near $199 a month.
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