C-peptide
What a GLP-1 receptor agonist actually does: which receptors it reaches, how it slows gastric emptying, and the satiety pathway it runs through.
What is C-peptide?
A fragment released by the pancreas one-for-one with your own insulin, used to tell who is still producing it.
GLP-1s work by amplifying endogenous insulin secretion, so people with very low C-peptide (under 0.6 ng/mL) tend to respond poorly — part of why the class is labeled for type 2 rather than type 1 diabetes.
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature.
Other terms under Mechanism
- GLP-1 receptor
- GIP receptor
- Dual agonist
- Gastric emptying
- Food noise
- Triple agonist
- Amylin
- GLP-1 tachyphylaxis
- Non-peptide GLP-1 agonist
- A1C (glycated hemoglobin)
- MASH / MASLD
- TBWL (Total Body Weight Loss)
- eGFR (estimated glomerular filtration rate)
- Visceral adipose tissue (VAT)
- AHI (apnea-hypopnea index)
- SNAC (oral semaglutide absorption enhancer)
Where the evidence lives
- STEP-1 metabolic endpoints
- The full GLP-1 glossary (149 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers