eGFR (estimated glomerular filtration rate)
What a GLP-1 receptor agonist actually does: which receptors it reaches, how it slows gastric emptying, and the satiety pathway it runs through.
What is eGFR (estimated glomerular filtration rate)?
Estimated glomerular filtration rate, the standard read on kidney filtration, in mL/min/1.73m².
Normal sits at 90 or above. Anything under 60 sustained across three months is what defines chronic kidney disease; stage 4 runs 15–29 and stage 5 falls below 15. In FLOW, semaglutide cut major kidney-disease events by 24% among diabetic patients whose kidneys were already failing (Perkovic 2024, PMID 38785209), and that is what drove the 2025 Ozempic label expansion.
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature.
Where eGFR (estimated glomerular filtration rate) comes up on this site
Connected terms
Other terms under Mechanism
- GLP-1 receptor
- GIP receptor
- Dual agonist
- Gastric emptying
- Food noise
- Triple agonist
- Amylin
- GLP-1 tachyphylaxis
- Non-peptide GLP-1 agonist
- A1C (glycated hemoglobin)
- MASH / MASLD
- TBWL (Total Body Weight Loss)
- C-peptide
- Visceral adipose tissue (VAT)
- AHI (apnea-hypopnea index)
- SNAC (oral semaglutide absorption enhancer)
Where the evidence lives
- Top GLP-1 kidney studies
- The full GLP-1 glossary (149 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers