eGFR (estimated glomerular filtration rate)
What a GLP-1 receptor agonist actually does: which receptors it reaches, how it slows gastric emptying, and the satiety pathway it runs through.
Definition
Estimated glomerular filtration rate, the standard read on kidney filtration in mL/min/1.73m². 90 or above is normal; under 60 for three months or more defines chronic kidney disease; stage 4 is 15–29 and stage 5 is under 15. FLOW showed semaglutide cut major kidney-disease events 24% in type 2 diabetes with CKD (Perkovic 2024, PMID 38785209), which drove the 2025 Ozempic label expansion.
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.
Other terms under Mechanism
- GLP-1 receptor
- GIP receptor
- Dual agonist
- Gastric emptying
- Food noise
- Triple agonist
- Amylin
- GLP-1 tachyphylaxis
- Non-peptide GLP-1 agonist
- A1C (glycated hemoglobin)
- MASH / MASLD
- TBWL (Total Body Weight Loss)
- C-peptide
- Visceral adipose tissue (VAT)
- AHI (apnea-hypopnea index)
- SNAC (oral semaglutide absorption enhancer)
Where the evidence lives
- Top GLP-1 kidney studies
- The full GLP-1 glossary (149 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers