PreventiveMD vs Sesame Care
Sesame Care costs $24 less a month, and both sell semaglutide, tirzepatide and orforglipron.
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If you are choosing between PreventiveMD and Sesame Care, the first difference is cost: Sesame Care is $24 a month cheaper at the entry price. Both prescribe semaglutide, tirzepatide and orforglipron, so moving from one to the other would not change your drug. PreventiveMD leads our six-part score, 7.4 to 6.5.
PreventiveMD vs Sesame Care price
Sesame Care is the cheaper way in: $59 a month on a prepaid plan against $83 a month at PreventiveMD. That is $24 less each month (29% lower), or about $288 over a year of treatment.
Sesame Care's figure is a monthly average of a plan billed for several months at once, so the first charge is larger than the number shown.
Drug by drug: Semaglutide is cheaper at PreventiveMD ($83 a month vs $149 a month); tirzepatide is cheaper at PreventiveMD ($97 a month vs $299 a month); orforglipron costs the same at both, $149 a month.
Medications and formats
Both sell semaglutide, tirzepatide and orforglipron.
On format, PreventiveMD prices compounded injections and brand-name pens, while Sesame Care prices compounded injections, brand-name pens and an oral option.
Where each one treats patients
PreventiveMD lists 36 states, and Sesame Care does not publish where it ships.
Pricing
PreventiveMD
As low as $83/mo, all-in.
As low as $97/mo, all-in.
Medication starts at $149/mo; a separate $49/mo membership fee applies to brand plans
Medication starts at $149/mo; a separate $49/mo membership fee applies to brand plans
Medication starts at $299/mo; a separate $49/mo membership fee applies to brand plans
Sesame Care
Month-to-Month $99/mo, 3-Month $39/mo, 6-Month $49/mo, Annual $59/mo; includes video visits, unlimited messaging, follow-ups, labs (savings $60/3mo, $180/6mo, $480/yr)
$199/mo for the first two months; new self-pay patients, lowest doses (0.25/0.5mg) only. Sesame's FAQ set the offer to end June 30, 2026.
low doses
high doses; maintenance dose $50/mo cheaper than Wegovy injection
NEW published pricing: $199 first two months (same new-self-pay intro terms as Wegovy); 2mg is $499/mo
$399/mo for 5mg; $449/mo for 7.5mg, 10mg, 12.5mg and 15mg.
$399/mo 5mg, $499/mo 7.5mg, $699/mo 10-15mg (program page shows $398/$698 — Sesame's own pages disagree by $1)
NEW row on program page: 'Zepbound® Tirzepatide Starts at $1,086 per / mo' (retail-channel pen, distinct from LillyDirect KwikPen)
NEW published pricing: $199/mo (2.5mg), $299/mo (5.5mg, 9mg), $349/mo (14.5mg, 17.2mg); previously feature-only with no pricing row
'Price with insurance: as low as $25 per / mo.' — copay varies by plan/PA outcome
What each price covers
PreventiveMD's price also covers the clinician visit and the medication itself, which Sesame Care does not claim.
PreventiveMD is silent on shipping, lab work and coaching.
Sesame Care does not say what its price includes.
That matters most for the drug: unless Sesame Care confirms otherwise, budget for medication on top of its listed price.
PreventiveMD
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
Sesame Care
Inclusions not disclosed.
Where each one scores higher
Overall, PreventiveMD scores 7.4 and Sesame Care 6.5 out of 10.
PreventiveMD is stronger on value (5.0 vs 3.7), user experience (8.0 vs 7.5), trust & safety (7.5 vs 6.5), accessibility (7.8 vs 5.0) and support (5.5 vs 5.0).
Effectiveness is within half a point.
PreventiveMD
7.4/10
Sesame Care
6.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither PreventiveMD nor Sesame Care has an FDA warning letter on record with us.
Features & Coverage
| Feature | PreventiveMD | Sesame Care |
|---|---|---|
| Starting Price | $83/mo | ✓$59/mo prepaid |
| Features | 8 features | 8 features |
| States Available | 36 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warning Letters | None | None |
About PreventiveMD
All-in figures start at $83/mo for compounded semaglutide and $97/mo for compounded tirzepatide. Foundayo, Zepbound and Wegovy come as brands under a membership arrangement. Requests reach a US-licensed provider inside 24 hours, and once approved the drug is sent to your door with care continuing through a portal online. Peptide therapy shares the platform with the GLP-1 side, all physician-guided.
Read our full PreventiveMD review →About Sesame Care
A subscription running $39-$99/month pays for the clinical care and nothing else; drugs are charged separately at cash rates, which includes Zepbound from $299 through LillyDirect and a Wegovy self-pay promotion at $199/month. Nothing in the weight-loss line is compounded, only branded. Rather than working off a stocked formulary the way most weight-loss platforms do, Sesame prices transparently and puts patients in touch with independent provider practices.
Read our full Sesame Care review →Pros & Cons
PreventiveMD
What we like
- Semaglutide costs $149 a month, 85% below the $990 median for brand-name semaglutide across the sellers we compare
- Orforglipron costs $149 a month, close to the $149 median for brand-name orforglipron across the sellers we compare
- Tirzepatide costs $299 a month, 76% below the $1249 median for brand-name tirzepatide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication and clinician visits
- We found no FDA warning letters issued to PreventiveMD
Watch-outs
- Serves only 36 states, so check that yours is one of them
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Sesame Care
What we like
- Semaglutide costs $149 a month, 85% below the $990 median for brand-name semaglutide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- We found no FDA warning letters issued to Sesame Care
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Offers both oral and injectable options, so the format is your choice
Watch-outs
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its orforglipron, semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Sesame Care is where we would start, above all for oral orforglipron alongside the injectables. It also costs $24 less each month than PreventiveMD. PreventiveMD fits better if oral orforglipron alongside the injectables is your priority.
Choose PreventiveMD if…
You want oral orforglipron alongside the injectables and an opening price near $83 a month.
Choose Sesame Care if…
You want oral orforglipron alongside the injectables and an opening price near $59 a month.
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Sesame Care
Oral orforglipron alongside the injectables
From $59/mo
Get started →Collective
Flat any-dose pricing, if you can absorb a $199 annual membership on top
From $59/mo
Get started →Found
Tirzepatide at $169/month, 37% below the typical price
From $149/mo
Get started →PreventiveMD vs Sesame Care: FAQ
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Or see the full category ranking.
Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.