Framework vs NewSelf
Framework and NewSelf both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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Framework
Best for: semaglutide at $100/month, 63% below the typical price
Visit Framework →
If you are choosing between Framework and NewSelf, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. NewSelf leads our six-part score, 8.6 to 8.1. One of the two has an FDA warning letter on record, covered below.
Framework vs NewSelf price
Framework and NewSelf start at the same figure, $100 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $100 a month; tirzepatide is cheaper at Framework ($100 a month vs $144 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Framework does not publish where it ships, and NewSelf lists 49 states.
Pricing
Framework
NewSelf
All dosages same price
All dosages same price
What each price covers
Both prices cover the medication itself.
Framework's price also covers coaching, which NewSelf does not claim.
NewSelf's price also covers the clinician visit and shipping, which Framework does not claim.
Framework is silent on the clinician visit, shipping and lab work.
NewSelf is silent on lab work and coaching.
Framework
Covered by the monthly price
Medication
In the price
Clinician visits
Not stated
Shipping
Not stated
Lab work
Not stated
Coaching
In the price
NewSelf
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, NewSelf scores 8.6 and Framework 8.1 out of 10.
Framework is stronger on value (10.0 vs 9.4) and trust & safety (6.5 vs 5.5).
NewSelf is stronger on accessibility (9.8 vs 5.0) and support (7.0 vs 4.5).
Effectiveness and user experience are within half a point.
Framework
8.1/10
NewSelf
8.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent NewSelf a warning letter dated February 20, 2026 (letter 721472), and it is still open.
Framework has no FDA warning letter on record with us.
Features & Coverage
| Feature | Framework | NewSelf |
|---|---|---|
| Starting Price | $100/mo | $100/mo |
| Features | 5 features | ✓6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | ✓None | 1 letter |
About Framework
Cost can go as low as $25/week, which is roughly $100/mo; no membership fee applies. A doctor guides which of the compounded drugs, semaglutide or tirzepatide, a patient takes. The detail that stands out is the pharmacy: Framework names The Pharmacy Hub, which works under the FDA-registered 503B outsourcing pathway instead of the patient-specific 503A route nearly every direct-to-consumer competitor relies on.
Read our full Framework review →About NewSelf
NewSelf sells compounded semaglutide+ with B12 and glycine from $99.97/mo and compounded tirzepatide+ with B6 and glycine from $144.49/mo. It is LegitScript certified and available in 48 states plus Puerto Rico, using 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Framework
What we like
- Semaglutide costs $100 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $100 a month, 60% below the $250 median for compounded tirzepatide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication and coaching
- We found no FDA warning letters issued to Framework
Watch-outs
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
NewSelf
What we like
- Semaglutide costs $100 a month, 46% below the $185 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $144 a month, 42% below the $250 median for compounded tirzepatide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- Serves 49 states
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued NewSelf a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
NewSelf wins this one, 8.6 to 8.1, above all for semaglutide at $100/month, 47% below the typical price. Framework fits better if semaglutide at $100/month, 63% below the typical price is your priority.
Choose Framework if…
You want semaglutide at $100/month, 63% below the typical price and an opening price near $100 a month.
Choose NewSelf if…
You want semaglutide at $100/month, 47% below the typical price and an opening price near $100 a month.
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Get started →Framework vs NewSelf: FAQ
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