Direct Meds vs Trally Meds
Direct Meds and Trally Meds both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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Trally Meds
Best for: people who want posted monthly prices and phone support and can live without a named pharmacy
Visit Trally Meds →If you are choosing between Direct Meds and Trally Meds, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Trally Meds leads our six-part score, 6.6 to 6.4. One of the two has an FDA warning letter on record, covered below.
Direct Meds vs Trally Meds price
Direct Meds and Trally Meds start at the same figure, $249 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $249 a month; tirzepatide is cheaper at Direct Meds ($299 a month vs $349 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Neither Direct Meds nor Trally Meds publishes the states it serves, so enter your state at the very start of each sign-up.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
Trally Meds
A three-month supply is listed at $672, about $224 a month. The site's per-week figures divide each supply by four-week months.
A three-month supply is listed at $942, about $314 a month. The weekly price shown assumes a four-week month.
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
Direct Meds is silent on lab work and coaching.
Trally Meds is silent on lab work and coaching.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Trally Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Trally Meds scores 6.6 and Direct Meds 6.4 out of 10.
Direct Meds is stronger on value (3.7 vs 3.0).
Trally Meds is stronger on trust & safety (6.5 vs 3.5).
Effectiveness, user experience, accessibility and support are within half a point.
Direct Meds
6.4/10
Trally Meds
6.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
Trally Meds has no FDA warning letter on record with us.
Features & Coverage
| Feature | Direct Meds | Trally Meds |
|---|---|---|
| Starting Price | $249/mo | $249/mo |
| Features | 5 features | ✓7 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About Trally Meds
Trally Meds is a cash-pay telehealth service listing a Memphis, Tennessee office that sells compounded semaglutide and tirzepatide, plus hair, sexual health and anti-aging treatment. One month of semaglutide costs $249 and tirzepatide $349; a three-month supply is $672 or $942. The consultation and delivery are free, and plans refill automatically after each check-in that a provider approves.
Read our full Trally Meds review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 32% above the $188 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Trally Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
- We found no FDA warning letters issued to Trally Meds
Watch-outs
- Semaglutide costs $249 a month, 32% above the $188 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $349 a month, 40% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Direct Meds is where we would start, above all for compounded semaglutide at $249/month. Trally Meds fits better if people who want posted monthly prices and phone support and can live without a named pharmacy is your priority.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose Trally Meds if…
You want people who want posted monthly prices and phone support and can live without a named pharmacy and an opening price near $249 a month.
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Strut Health
Semaglutide at $99/month, 48% below the typical price
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Knowing which pharmacy fills the vial: it names Tru Meds Rx
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Compounded semaglutide at $175/month
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Get started →Direct Meds vs Trally Meds: FAQ
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