Direct Meds vs SkinnyRx
SkinnyRx costs $99.75 less a month, and both sell semaglutide and tirzepatide.
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If you are choosing between Direct Meds and SkinnyRx, the first difference is cost: SkinnyRx is $99.75 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Direct Meds leads our six-part score, 6.4 to 5.9. Both have drawn an FDA warning letter.
Direct Meds vs SkinnyRx price
SkinnyRx is the cheaper way in: $149.25 a month against $249 a month at Direct Meds. That is $99.75 less each month (40% lower), or about $1,197 over a year of treatment.
Drug by drug: Semaglutide is cheaper at SkinnyRx ($149.25 a month vs $249 a month); tirzepatide is cheaper at SkinnyRx ($224.25 a month vs $299 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format, Direct Meds prices compounded injections, while SkinnyRx prices compounded injections and an oral option.
Where each one treats patients
Neither Direct Meds nor SkinnyRx publishes the states it serves, so enter your state at the very start of each sign-up.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
SkinnyRx
'As low as $149.25/mo*' — plan-length/promo dependent (matches the sitewide '25% lower prices' promo, $199 x 0.75); standard single-month rate not published pre-intake. Microdose available; free overnight shipping.
'As low as $199/mo*' on /products/semaglutide-oral; once-daily.
'As low as $249/mo*' on /products/semaglutide-tablets.
'As low as $224.25/mo*' and 'Starting at $224.25/mo with free overnight shipping'; microdose available; once-weekly.
'As low as $224.25/mo*' on /products/tirzepatide-tablets; once-daily.
'$1,400/mo*' — '*Price shown applies to Monthly plan paid upfront or with buy now, pay later programs.' 'No membership fees. Same price at every dose.'
'$1,400/mo*' on /products/wegovy-injectable. Wegovy PILL is listed 'Unavailable' ('available via SkinnyRx Membership', fee not published).
'$1,400/mo*' on /products/mounjaro.
'$1,400/mo*' on /products/zepbound. Foundayo (orforglipron) pill also listed but 'Unavailable' — price not published.
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
Direct Meds is silent on lab work and coaching.
SkinnyRx is silent on lab work and coaching.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
SkinnyRx
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Direct Meds scores 6.4 and SkinnyRx 5.9 out of 10.
Direct Meds is stronger on user experience (8.0 vs 3.0) and trust & safety (3.5 vs 1.0).
SkinnyRx is stronger on value (6.5 vs 3.7).
Effectiveness, accessibility and support are within half a point.
Direct Meds
6.4/10
SkinnyRx
5.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
The FDA sent SkinnyRx a warning letter dated February 20, 2026 (letter 717989), and it is still open.
Features & Coverage
| Feature | Direct Meds | SkinnyRx |
|---|---|---|
| Starting Price | $249/mo | ✓$149.25/mo |
| Features | ✓5 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | 1 letter |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About SkinnyRx
SkinnyRx sells compounded semaglutide and tirzepatide as injectables, with a microdosing option, prescribed by licensed US clinicians. The consult and free overnight shipping are bundled into a single monthly cash price.
Read our full SkinnyRx review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
SkinnyRx
What we like
- Semaglutide costs $149.25 a month, 19% below the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $224.25 a month, 10% below the $250 median for compounded tirzepatide across the sellers we compare
- The monthly price includes the medication, clinician visits and shipping
- Offers both oral and injectable options, so the format is your choice
Watch-outs
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued SkinnyRx a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Direct Meds wins this one, 6.4 to 5.9, above all for compounded semaglutide at $249/month. SkinnyRx undercuts it by $99.75 a month, so if the monthly bill is what decides it, SkinnyRx is the pick. SkinnyRx fits better if starting below a standard dose, with microdose tiers is your priority.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose SkinnyRx if…
You want starting below a standard dose, with microdose tiers and an opening price near $149.25 a month.
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RNK Health
An oral route if you will not self-inject
From $197/mo
Get started →He & She MD
Starting below a standard dose, with microdose tiers
From $99/mo
Get started →Wellorithm
Compounded semaglutide at $247/month
From $247/mo
Get started →Direct Meds vs SkinnyRx: FAQ
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