GLP Watchdog

Direct Meds vs SkinnyRx

Direct Meds has an open FDA warning letter dated September 9, 2025. SkinnyRx has an open FDA warning letter dated February 20, 2026. No price lines up like for like. They share compounded semaglutide injection, but SkinnyRx's $99 is a first-month price.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / SkinnyRx

Direct Meds logo

Direct Meds

7.1/10

SkinnyRx logo

SkinnyRx

6.3/10

FDA warning letters
Pharmacy
None named in our record
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$248/moBrand-name semaglutide pill
States
48 states and DC
47 states
Checked
Prices captured Record checked October 2026
Prices captured Record checked October 2026
Visit Direct Meds
Visit SkinnyRx

Both Direct Meds and SkinnyRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, SkinnyRx 6.3). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. SkinnyRx has an open FDA warning letter dated February 20, 2026.

  2. 02

    Neither names the pharmacy that compounds its medication.

  3. 03

    No price lines up like for like. They share compounded semaglutide injection, but SkinnyRx's $99 is a first-month price.

  4. 04

    Only SkinnyRx lists a price for brand-name semaglutide pen, brand-name tirzepatide pen and brand-name semaglutide pill.

  5. 05

    Direct Meds covers one state SkinnyRx does not.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; SkinnyRx states you can cancel at any time.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

SkinnyRx

Compounded semaglutide injection

$297/mo

$3,564 a year

$99/mo

first month only; not compared

Compounded tirzepatide injection

$399/mo

$4,788 a year

$99/mo

first month only; not compared

Compounded oral semaglutide

$249/mo

$2,988 a year

$149/mo

first month only; not compared

Compounded oral tirzepatide

$299/mo

$3,588 a year

$199/mo

first month only; not compared

Brand-name semaglutide pen
Not sold or not priced

$1,400/mo

$16,800 a year

Brand-name tirzepatide pen
Not sold or not priced

$1,400/mo

$16,800 a year

Brand-name semaglutide pill
Not sold or not priced

$248/mo

$2,976 a year

Foundayo (orforglipron) pill
Not sold or not priced

$248/mo

$2,976 a year

Price includes
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Cancel any time
No
Yes, stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
None stated; subscriptions auto-renew until canceled at least 5 days before the renewal date
Refunds
No refunds for medication already received; $35 disposal fee on returns
Full refund before a provider completes the prescription review; no refunds for partially used subscription periods

Read off each seller’s own pages. Direct Meds: October 17, 2026. SkinnyRx: October 30, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10

The record gives Direct Meds no edge on this pair.

  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for SkinnyRx

6.3/10
  • Sells brand-name semaglutide pen and brand-name tirzepatide pen, which Direct Meds does not price
  • States you can cancel at any time
  • Open FDA warning letter, February 20, 2026
  • Names no compounding pharmacy
Visit SkinnyRx

Scores

Direct Meds 7.1 · SkinnyRx 6.3 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
5.6

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
3.0

Trust & Safety15%

4.5A
vs
B
2.0

Accessibility10%

9.7A
vs
B
9.5

Support10%

7.0A
vs
B
7.0

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs SkinnyRx: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. SkinnyRx has an open FDA warning letter dated February 20, 2026. Letters are matched to a seller by company, domain and address, never by a similar name.
Neither names the pharmacy that compounds its medication.
No price lines up like for like. They share compounded semaglutide injection, but SkinnyRx's $99 is a first-month price. We only set two prices against each other when they are for the same product and both are standing month-to-month or 4-week rates.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). SkinnyRx states you can cancel at any time; refunds: full refund before a provider completes the prescription review; no refunds for partially used subscription periods.
Both Direct Meds and SkinnyRx are affiliate partners: we are paid if you sign up through our links. Neither is featured. Scores are computed the same way for both (Direct Meds 7.1, SkinnyRx 6.3).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register

Brand names on this page are registered marks. Novo Nordisk holds Wegovy®, Ozempic® and Rybelsus®; Eli Lilly holds Zepbound®, Mounjaro® and Foundayo®. Neither company has any tie to GLP Watchdog. Trademarks