GLP Watchdog

Direct Meds vs Polly

Direct Meds has an open FDA warning letter dated September 9, 2025. Polly has none. On compounded tirzepatide injection, Polly costs $1,440 less a year at standing rates: $279 a month against $399 a month at Direct Meds. It is one of two products the two sell at comparable terms.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / Polly

Featured pick (affiliate partner)

Direct Meds logo

Direct Meds

7.1/10

Polly logo

Polly

8.4/10

FDA warning letters
None on record
Pharmacy
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$179/moCompounded semaglutide injection
States
48 states and DC
All 50 states
Checked
Prices captured Record checked October 2026
Prices captured Record checked November 2026
Visit Direct Meds
Visit Polly

Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Polly pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, Polly 8.4). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. Polly has none.

  2. 02

    Polly names two pharmacies, all 503A. Direct Meds names no compounding pharmacy in our record.

  3. 03

    On compounded tirzepatide injection, Polly costs $1,440 less a year at standing rates: $279 a month against $399 a month at Direct Meds. It is one of two products the two sell at comparable terms.

  4. 04

    Only Direct Meds lists a price for compounded oral semaglutide and compounded oral tirzepatide.

  5. 05

    Polly covers two states Direct Meds does not.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; Polly does not state its cancellation terms.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

Polly

Compounded semaglutide injection

$297/mo

$3,564 a year

$179/moLower

$2,148 a year

Compounded tirzepatide injection

$399/mo

$4,788 a year

$279/moLower

$3,348 a year

Compounded oral semaglutide

$249/mo

$2,988 a year

Not sold or not priced
Compounded oral tirzepatide

$299/mo

$3,588 a year

Not sold or not priced
Price includes
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Cancel any time
No
Not stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
Month to month, or a 3- or 6-month supply charged at checkout
Refunds
No refunds for medication already received; $35 disposal fee on returns
Full refund only before the medical intake is submitted; 3- and 6-month plans cannot be refunded once the first month has passed
Early-exit fee
Not stated
Yes

Read off each seller’s own pages. Direct Meds: October 17, 2026. Polly: October 17, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10
Featured pick (affiliate partner)
  • Sells compounded oral semaglutide and compounded oral tirzepatide, which Polly does not price
  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for Polly

8.4/10
  • No FDA warning letter on record
  • $1,416 a year less on compounded semaglutide injection
  • $1,440 a year less on compounded tirzepatide injection
  • Names its compounding pharmacy
Visit Polly

Scores

Direct Meds 7.1 · Polly 8.4 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
5.8

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
8.0

Trust & Safety15%

4.5A
vs
B
10.0

Accessibility10%

9.7A
vs
B
10.0

Support10%

7.0A
vs
B
7.0

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs Polly: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. Polly has none. Letters are matched to a seller by company, domain and address, never by a similar name.
Polly names two pharmacies, all 503A. Direct Meds names no compounding pharmacy in our record. A 503A pharmacy compounds for named patients on a prescription; a 503B outsourcing facility is registered with FDA and inspected under federal manufacturing rules.
Polly, by $1,416 a year at standing rates. Direct Meds: $297 a month, about $3,564 a year. Polly: $179 a month, about $2,148 a year.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). Polly does not state its cancellation terms.
Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Polly pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, Polly 8.4).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register