Direct Meds vs Nurx
Nurx costs $70 less a month, and both sell semaglutide and tirzepatide.
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If you are choosing between Direct Meds and Nurx, the first difference is cost: Nurx is $70 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Direct Meds leads our six-part score, 6.4 to 4.8. One of the two has an FDA warning letter on record, covered below.
Direct Meds vs Nurx price
Nurx is the cheaper way in: $179 a month against $249 a month at Direct Meds. That is $70 less each month (28% lower), or about $840 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Nurx ($179 a month vs $249 a month); tirzepatide is cheaper at Nurx ($179 a month vs $299 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
Neither Direct Meds nor Nurx publishes the states it serves, so enter your state at the very start of each sign-up.
Pricing
Direct Meds
'As low as $249' per month, on a 90-day supply billed monthly; some doses run as low as $237/mo.
'As low as $297' per month ($9.58 a day), an 84-day three-pack billed monthly.
'As low as $299' per month ($9.65 a day) on a 90-day supply billed monthly. Down from $399 earlier.
'As low as $399' per month ($12.87 a day).
Nurx
Range up to $299/mo
Range up to $299/mo
What each price covers
Direct Meds' price also covers the clinician visit, the medication itself and shipping, which Nurx does not claim.
Direct Meds is silent on lab work and coaching.
Nurx is silent on shipping, lab work and coaching.
That matters most for the drug: unless Nurx confirms otherwise, budget for medication on top of its listed price.
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Nurx
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Direct Meds scores 6.4 and Nurx 4.8 out of 10.
Direct Meds is stronger on value (3.7 vs 3.0), user experience (8.0 vs 3.0) and support (7.0 vs 0.0).
Nurx is stronger on trust & safety (4.0 vs 3.5).
Effectiveness and accessibility are within half a point.
Direct Meds
6.4/10
Nurx
4.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent Direct Meds a warning letter dated September 9, 2025 (letter 716822), and it is still open.
Nurx has no FDA warning letter on record with us.
Features & Coverage
| Feature | Direct Meds | Nurx |
|---|---|---|
| Starting Price | $249/mo | ✓$179/mo |
| Features | ✓5 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →About Nurx
Nurx is an established women's telehealth brand running tiered GLP-1 weight loss programs.
Read our full Nurx review →Pros & Cons
Direct Meds
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $299 a month, 20% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued Direct Meds a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Nurx
What we like
- We found no FDA warning letters issued to Nurx
Watch-outs
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Not included in the monthly price: medication, clinician visits
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Direct Meds wins this one, 6.4 to 4.8, above all for compounded semaglutide at $249/month. Nurx undercuts it by $70 a month, so if the monthly bill is what decides it, Nurx is the pick.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose Nurx if…
You want the lower starting price and an opening price near $179 a month.
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Sesame Care
Oral orforglipron alongside the injectables
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Tirzepatide at $169/month, 37% below the typical price
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Get started →Direct Meds vs Nurx: FAQ
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