GLP Watchdog

Direct Meds vs Enhance MD

Direct Meds has an open FDA warning letter dated September 9, 2025. Enhance MD has none. On compounded tirzepatide injection, Enhance MD costs $511 less a year at standing rates: $329 a month (billed every 4 weeks) against $399 a month at Direct Meds. It is one of two products the two sell at comparable terms.

To see where both sit among the other sellers, read our best weight-loss injection providers board.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

Direct Meds / Enhance MD

Featured pick (affiliate partner)

Direct Meds logo

Direct Meds

7.1/10

Enhance MD logo

Enhance MD

7.5/10

FDA warning letters
None on record
Pharmacy
None named in our record
Lowest standing price
$249/moCompounded oral semaglutide
$249/moCompounded semaglutide injection, billed every 4 weeks
States
48 states and DC
40 states and DC
Checked
Prices captured Record checked October 2026
Prices captured Record checked October 2026
Visit Direct Meds
Visit Enhance MD

Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Enhance MD pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, Enhance MD 7.5). How we are paid

What the record shows

  1. 01

    Direct Meds has an open FDA warning letter dated September 9, 2025. Enhance MD has none.

  2. 02

    Enhance MD names five pharmacies, all 503A. Direct Meds names no compounding pharmacy in our record.

  3. 03

    On compounded tirzepatide injection, Enhance MD costs $511 less a year at standing rates: $329 a month (billed every 4 weeks) against $399 a month at Direct Meds. It is one of two products the two sell at comparable terms.

  4. 04

    Only Direct Meds lists a price for compounded oral semaglutide and compounded oral tirzepatide.

  5. 05

    Direct Meds covers eight states Enhance MD does not.

  6. 06

    Direct Meds holds you to a 90-day supply shipped at once, remaining months billed every 30 days; Enhance MD states you can cancel at any time.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

Direct Meds

Enhance MD

Compounded semaglutide injection

$297/mo

$3,564 a year

$249/moLower

$3,237 a year, 13 charges

Compounded tirzepatide injection

$399/mo

$4,788 a year

$329/moLower

$4,277 a year, 13 charges

Compounded oral semaglutide

$249/mo

$2,988 a year

Not sold or not priced
Compounded oral tirzepatide

$299/mo

$3,588 a year

Not sold or not priced
Price includes
Medication, clinician visits, shipping
Medication, clinician visits, shipping, labs
Cancel any time
No
Yes, stated
Minimum term
90-day supply shipped at once, remaining months billed every 30 days
None month to month; longer plans charge once per 12, 24 or 48 weeks
Refunds
No refunds for medication already received; $35 disposal fee on returns
Full refund of the initial payment if found ineligible during onboarding; no returns on prescription products

Read off each seller’s own pages. Direct Meds: October 17, 2026. Enhance MD: October 17, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for Direct Meds

7.1/10
Featured pick (affiliate partner)
  • Sells compounded oral semaglutide and compounded oral tirzepatide, which Enhance MD does not price
  • Lists 48 states against 40
  • Open FDA warning letter, September 9, 2025
  • Names no compounding pharmacy
  • Minimum commitment before you can cancel
Visit Direct Meds

The case for Enhance MD

7.5/10
  • No FDA warning letter on record
  • $327 a year less on compounded semaglutide injection
  • $511 a year less on compounded tirzepatide injection
  • Names its compounding pharmacy
Visit Enhance MD

Scores

Direct Meds 7.1 · Enhance MD 7.5 out of 10. Six weighted parts.

Value25%

4.2A
vs
B
3.5

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
7.0

Trust & Safety15%

4.5A
vs
B
9.0

Accessibility10%

9.7A
vs
B
8.4

Support10%

7.0A
vs
B
8.5

The score is the same formula for every seller. Payment does not enter it. Method

Direct Meds vs Enhance MD: questions

Direct Meds has an open FDA warning letter dated September 9, 2025. Enhance MD has none. Letters are matched to a seller by company, domain and address, never by a similar name.
Enhance MD names five pharmacies, all 503A. Direct Meds names no compounding pharmacy in our record. A 503A pharmacy compounds for named patients on a prescription; a 503B outsourcing facility is registered with FDA and inspected under federal manufacturing rules.
Enhance MD, by $327 a year at standing rates. Direct Meds: $297 a month, about $3,564 a year. Enhance MD: $249 a month (billed every 4 weeks), about $3,237 a year.
Direct Meds has a minimum term (90-day supply shipped at once, remaining months billed every 30 days). Enhance MD states you can cancel at any time; refunds: full refund of the initial payment if found ineligible during onboarding; no returns on prescription products.
Direct Meds is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Enhance MD pays us nothing. The scores are computed the same way for both and are shown as computed (Direct Meds 7.1, Enhance MD 7.5).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register