MariTide (Maridebart Cafraglutide)
Every GLP-1 the FDA has approved, and the active ingredient inside each one.
Definition
Amgen's investigational once-monthly conjugate, maridebart cafraglutide, pairing a GLP-1 agonist with a GIP ANTAGONIST. Phase 2 (NEJM 2025) reported 16–20% weight loss. The GIP direction is the opposite of tirzepatide's, which is why it is interesting rather than incremental. Not approved.
GLP-1 pipeline: survodutide, MariTide, ecnoglutide →
GLP Watchdog writes these definitions from FDA labels and peer-reviewed PubMed literature. Not one of them is an AI-generated summary.
Other terms under Drugs and brands
Where the evidence lives
- GLP-1 pipeline: survodutide, MariTide, ecnoglutide
- The full GLP-1 glossary (149 terms, 8 categories)
- Research articles — written from primary sources
- Tools and calculators
- Compare GLP-1 telehealth providers