Ozempic Dosing & Titration Schedule
Where semaglutide begins, every step it climbs, and where it stops — maintenance and maximum both — read straight off the FDA prescribing information.
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Ozempic Titration Schedule
Each rung of the Ozempic ladder, taken from Dosage & Administration in its FDA label (DailyMed SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79). The schedule you actually follow is the one your prescriber writes; this is the reference behind it, not advice about your case.
| Step | Dose | When |
|---|---|---|
| 1 | 0.25 mg once weekly | Weeks 1–4 — a run-in dose; it does not control blood sugar |
| 2 | 0.5 mg once weekly | Once 4 weeks at 0.25 mg are done |
| 3 | 1 mg once weekly | 4 weeks or more at 0.5 mg, if control is still short |
| 4 | 2 mg once weekly | 4 weeks or more at 1 mg, if control is still short |
Source: Ozempic FDA prescribing information via DailyMed (SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79), Section 2 Dosage & Administration, read on 2026-06-01. Treat this as a summary: the full label is the document, and your prescriber's instructions are what you follow.
Ozempic Dosing at a Glance
How to titrate safely
Two conditions gate every step up: 4 weeks minimum at the dose you are on, and a genuine need for more glycemic control. Inject on the same weekday each time — the hour does not matter, and neither does whether you have eaten.
One rule governs the whole ladder: you only climb if you are tolerating where you already are, and you hold or slow down when side effects flare. Outrunning the label's schedule does not get you results sooner. What it reliably produces is more nausea and more of everything else the gut does in response.
If you miss a dose or can't tolerate a step
Missed a dose? How late is too late is not the same answer for every drug. Read GLP-1 missed-dose rules by drug for what Ozempic specifically allows, before you double up or write the dose off.
Can't tolerate a dose increase? Holding at the current dose, or waiting longer before the next step, is something the label explicitly permits. What each step tends to bring is set out on the Ozempic side effects page, then talk to your prescriber before changing your schedule.
Compare every Ozempic provider
Your dose and your titration plan are set by a prescriber before anything is written. Current price, verification status, product form and the states each seller ships to are all on one screen.