From the FDA label (DailyMed)Verified 2026-07-12

Ozempic Storage & Handling

Where semaglutide belongs and for how long: the cold range, the warm allowance, and what to do about a dose that froze or sat in the sun — read straight off the FDA prescribing information.

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Ozempic Storage at a Glance

Refrigerated (unopened)
36°F to 46°F (2°C to 8°C)
Room-temperature allowance
Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days.
Freezing
Do not freeze OZEMPIC. Do not use OZEMPIC if it has been frozen.
Light
Keep OZEMPIC away from heat and out of direct light; store it in the original carton until time of administration, and don't store it directly against the refrigerator's cooling element.

Source: Ozempic FDA prescribing information via DailyMed (SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79), Section 16.2 How Supplied/Storage and Handling, read on 2026-07-12. Treat this as a summary: the full label and the patient instructions in your box are the authority.

Handling the pen or vial

Once you start using it: the in-use window is 56 days after first use (pen) / 28 days (prefilled syringe). Write down the day you first used it — on the device itself or in your calendar — because the label says discard at the end of that window regardless of how much is left.

The carton it arrived in is the light protection, and the obvious place to write the first-use date, so keep the pen or vial inside it wherever you can. Between doses the needle comes off; a pen should never be stored with one attached.

Traveling with Ozempic

Unopened, it belongs in a fridge. Opened, it can spend up to 56 days at room temperature, cap on between doses and out of sun and heat. Put the first-use date somewhere you will see it — on the pen barrel or in your calendar — because nothing on the device counts down for you.

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Frequently Asked Questions

An unopened Ozempic belongs in the fridge at 36°F to 46°F (2°C to 8°C). Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days. Taken from the FDA label on DailyMed, SetID adec4fd2-6858-4c99-91d4-531f5f2a2d79, Section 16.2, read on 2026-07-12.
It survives, but on a clock. Pen (after first use): 59°F to 86°F (15°C to 30°C), or refrigerated, for up to 56 days. Prefilled syringe (before first use): 46°F to 86°F (8°C to 30°C) for up to 28 days. Once that clock starts it does not stop: throw the product away after 56 days after first use (pen) / 28 days (prefilled syringe), however much is left inside.
Do not freeze OZEMPIC. Do not use OZEMPIC if it has been frozen. Where you cannot be certain a dose stayed above freezing, treat it as unusable and ask your pharmacy for a replacement rather than risking it.
Keep OZEMPIC away from heat and out of direct light; store it in the original carton until time of administration, and don't store it directly against the refrigerator's cooling element.