Best Semaglutide Providers at 0.25mg in 2026 — Ranked & Reviewed
One filter builds this table: the seller publishes a semaglutide price at 0.25mg. Sellers who stock other tiers and skip this one drop out, which is why the list runs shorter than the full semaglutide board. Each row carries the starter dose figure a seller advertises, the date we last checked it, and our independent score. Whether 0.25mg is the right tier for you is a call for your prescriber.
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3 semaglutide providers compared · independently scored against our six-factor methodology.
Methodology & sources
Each provider here carries a score from our published six-factor rubric[1], and the list is then cut down to the dose named in the page title.
Published Phase 3 efficacy for semaglutide 2.4 mg (~14.9% mean weight loss over 68 weeks) comes from the STEP 1 trial[2]. The SURMOUNT-5 head-to-head published in 2025 directly compared tirzepatide and semaglutide[3].
Quick Picks: Top 3
Detailed Reviews
PeptidesRx
Best for: compounded semaglutide at $169/month
Pricing is published, and shipping goes directly to patients nationwide. PeptidesRx sells physician-supervised compounded semaglutide and tirzepatide plus a broader prescription peptide menu, from a licensed telehealth platform based in Fort Worth, TX. Good-faith examinations are conducted by licensed nurse practitioners under a board-certified medical director. It calls itself compliance-focused, an alternative to gray-market peptide vendors.
Score Breakdown
Invigor Medical
Best for: compounded semaglutide at $199/month
Invigor Medical has run for years out of Pasco, WA, an established clinic whose licensed providers cover all 50 states nationwide. Weight loss there runs on compounded semaglutide and tirzepatide. Sexual wellness treatments and peptide therapy fill out the rest of the menu.
Score Breakdown
Coby Health
Best for: compounded semaglutide at $159/month
Coby Health LLC runs a direct-to-consumer telehealth marketplace out of Chicago and Springfield, IL, with a BBB file opened 3/2025. Compounded semaglutide starts at $99/mo and compounded tirzepatide at $179/mo, both on a 6-mo bundle at the 0.25mg and 2.5mg starting doses. There is no membership fee. It is LegitScript Certified (seal 38387067), and clinical care runs through Beluga Health P.A., part of the Dr. Jonah Mink network. It does not publicly disclose its compounding pharmacy partners.
Score Breakdown
Frequently Asked Questions
Sources & methodology — as of August 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 3.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Garvey WT et al.)— New England Journal of Medicine.PMID: 40334173.