MEDVi vs Piper
Piper costs $114 less a month, and both sell semaglutide.
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Piper
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Piper →If you are choosing between MEDVi and Piper, the first difference is cost: Piper is $114 a month cheaper at the entry price. Both prescribe semaglutide, so moving from one to the other would not change your drug. Piper leads our six-part score, 7.4 to 7.1. One of the two has an FDA warning letter on record, covered below.
MEDVi vs Piper price
Piper is the cheaper way in: $135 a month against $249 a month at MEDVi. That is $114 less each month (46% lower), or about $1,368 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Piper ($135 a month vs $249 a month).
Medications and formats
Both sell semaglutide; only Piper lists tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
MEDVi lists 48 states, and Piper lists 50 states.
They overlap in 48 states. Piper alone covers Mississippi and North Dakota.
Pricing
MEDVi
Refills are locked in at $299. The first month is $179 in the 'SUMMER Sale,' and some MEDVi landing pages offer the first month at $149.
Flat 'Starting at $249' — no intro discount shown.
$99 Membership + Medication Cost — medication cost not published (varies/insurance may reimburse). 'Availability is subject to change.'
$99 Membership + Medication Cost — medication cost not published. COMPOUNDED tirzepatide ($349 in our current entry) is no longer published anywhere on glp1.medvi.org, home.medvi.org, or the intake flow (0 mentions) — treat as discontinued/not published, do not carry the $349 row forward.
Piper
What each price covers
Both prices cover the clinician visit, the medication itself and shipping.
MEDVi's price also covers coaching, which Piper does not claim.
MEDVi is silent on lab work.
Piper is silent on lab work and coaching.
MEDVi
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Piper
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Piper scores 7.4 and MEDVi 7.1 out of 10.
MEDVi is stronger on support (8.5 vs 7.0).
Piper is stronger on trust & safety (8.5 vs 6.0).
Value, effectiveness, user experience and accessibility are within half a point.
MEDVi
7.1/10
Piper
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent MEDVi a warning letter dated February 20, 2026 (letter 721455), and it is still open.
Piper has no FDA warning letter on record with us.
Features & Coverage
| Feature | MEDVi | Piper |
|---|---|---|
| Starting Price | $249/mo | ✓$135/mo |
| Features | ✓7 features | 3 features |
| States Available | 48 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About MEDVi
Two clinical groups do the treating at MEDVi: CareGLP Affiliated P.C.s, plus clinicians from OpenLoop Health. Its weight-loss menu holds compounded GLP-1s, injections and tablets alike, the molecule being semaglutide, next to Zepbound and Wegovy under their brand names. Licensed US pharmacies fill all of it.
Read our full MEDVi review →About Piper
Piper is a telehealth weight loss seller offering compounded GLP-1 medications at competitive prices.
Read our full Piper review →Pros & Cons
MEDVi
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits, shipping and coaching
- Serves 48 states
- Names 3 pharmacies that fill its prescriptions, which most sellers do not
Watch-outs
- Semaglutide costs $249 a month, 35% above the $184 median for compounded semaglutide across the sellers we compare
- The FDA has issued MEDVi a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide is compounded rather than FDA-approved, so it has not been reviewed by the agency for safety, effectiveness or manufacturing quality
Piper
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- Serves all 50 states
- We found no FDA warning letters issued to Piper
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Piper wins this one, 7.4 to 7.1, above all for coverage in all 50 states, which most sellers will not confirm. It also costs $114 less each month than MEDVi. MEDVi fits better if knowing which pharmacy fills the vial: it names Triad Rx is your priority.
Choose MEDVi if…
You want knowing which pharmacy fills the vial: it names Triad Rx and an opening price near $249 a month.
Choose Piper if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $135 a month.
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Breeze Meds
Knowing which pharmacy fills the vial: it names Belmar Pharmacy
From $199/mo
Get started →HealthRX
Compounded semaglutide at $133/month
From $133/mo
Get started →RNK Health
An oral route if you will not self-inject
From $197/mo
Get started →MEDVi vs Piper: FAQ
Close alternatives to MEDVi and Piper
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- Piper vs Livv
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Or see the full category ranking.